Bezisterim produces moderate and broad treatment effects in several different long COVID subsets. BioVie, the drug manufacturer, hopes to move forward with a big phase III trial.

Could a new mitochondrial drug called IVO-21 be the answer to the energy problems in ME/CFS, fibromyalgia, and long COVID?

A long COVID study examining, for the first time, energy levels in the brain, found them to be depleted in a large region called the cingulate cortex.

A large neuroplasticity long COVID trial appears to noticeably improve a small subset of patients, and has small to modest effects on most others.

A large UK Long COVID treatment trial that assessed 3 drugs/drug combos utterly failed. It's not alone - none of the 14 or so largish long COVID trials have produced good results. Perhaps it's not a s...

Health Update –  continued slow improvement! Hot Button Post – the reason Health Rising almost never posts on political issues is that they hardly ever intrude upon medical research. In this case, the...

Geoff’s Narration The GIST   The 2026 PolyBio Spring Symposium – Pt I One way to gauge the health of a field is by the number of conferences/symposia it supports. From the looks of things, the long–CO...

Dr. Selin and company believe they can solve one of the key mysteries of ME/CFS and long COVID: exactly why the T-cells are getting pummeled.

A major study determines that autoimmunity is causing major symptoms in long COVID ultimately laying the groundwork for precision-guided treatments

A long COVID study uncovers a subset of patients with microclots and signs of blood vessel damage who, if the findings are validated, might benefit from rarely used treatments.

A novel immunomodulatory treatment approach to ME/CFS appears and a paradox could be resolved....

Only 10 major long COVID clinical trials have been published thus far but that's enough to come away with some interesting takeaways. They include treatments that prevent long COVID don't necessarily ...

What happens when you throw ten or so very different ME/CFS studies together? You get some core themes popping out. Check out the blog and see what they are.

An in-depth exploration of Dr. Ruhoy's treatment guide "Invisible No More" for ME/CFS, long COVID and similar diseases

The massive Sequence ME/CFS and long COVID whole genome sequencing project aims to find the precision drivers of these illnesses

Geoff’s Narration The GIST   “These substances represent a potentially revolutionary approach to pharmacological pain management,” Crozpek et. Al. 2025 History has shown that our notions of what treat...

The big IMPACC long COVID study findings suggest that inflammation and reduced male sex hormone levels may be playing havoc with the small blood vessels in long COVID -= and ME/CFS

The Open Medicine Foundation's huge Bioquest project has the potential to transform ME/CFS patients experience with doctors, dramatically enhance research and get drug companies finally interested in ...

A deep dive into the genome of ME/CFS patients points to many genetic causes of ME/CFS most of which impact energy production, the metabolism, and blood flows.

Amatica's huge gene expression database attempts to identify which subsets a person belongs in and which treatments that may work for them.

Geoff’s Narration The GIST Muscles on a Chip Whoa, another muscle study. We recently reported on a proteomic study suggesting that muscle repair problems contribute to post-exertional malaise in ME/CF...

A Dutch ME/CFS autopsy report findings multiple severe problems in the HPA axis of ME/CFS patients.

More evidence is presented that the most severely ill fibromyalgia patients have an autoimmune disease.

Solve ME Catalyst Award winner Dr. Iwasaki explains a subset of long COVID patients may have an autoimmune disease. Now she moves onto ME/CFS.

Complex, chronic illness experts discuss what GLP-1 agonists can and can't do in diseases like ME/CFS, long COVID, and POTS. Plus new long COVID trials.

Geoff’s Narration The GIST   Just months after the publication of the first large ME/CFS GWAS study comes an enormous FM GWAS study. Notice how these two diseases seem to be marching hand in hand. Bot...

Geoff’s Translation The GIST   “With this breakthrough, we are proud to enable a first-in-class test that can address an unmet need for a quick and reliable diagnostic for a complex, challenging-to-id...

The RECOVER Initiative announces four more clinical trials for long COVID including low dose naltrexone, bariticinib, GLP-1 agonists, and stellate ganglion blockade.

In Good Health cookbook by Rachel Riggs

Geoff’s Narration The GIST   From viral persistence to complex immune studies, to tissue sampling, to assessing heavy-duty immune treatment trials and large treatment trials, long-COVID researchers ar...

Vagus nerve stimulation could reduce inflammation, pain and stress in ME/CFS, fibromyalgia and long COVID. A long COVID trial is underway.

BioMapAI study suggests the gut problems in ME/CFS are driving other system malfunctions and symptoms.

The Senate Appropriations bill provides strong support for ME/CFS and long COVID. Now it moves to the House.

Could ME;/CFS and fibromyalgia be on the narcoleptic disease spectrum? After decades of work on these diseases, Dr. Perrino believes so...

Tonmya is the first FDA approved drug for use in fibromyalgia in 15 years. Seth Lederman, CEO of Tonix Pharmaceuticals, talked about how the drug was developed, what it does, and when it will become a...

Geoff’s Narration The GIST    “We’re seeing things in the front of the brain, we’re seeing issues in the back of the brain, we’re seeing a lot of things in between…this is a brain-wide issue”. It’s sa...

A B-cell depleter called daratumumab does well in an early trial in ME/CFS. A larger trial is underway.

The massive TreatME survey assessed the effectiveness of 150 treatments in ME/CFS and long COVID.

Transcranial focused ultrasound (tFUS) may be able to reach deep enough in the brain to help people with fibromyalgia, ME/CFS and long COVID.

Dr. Courtney Craig explains why carnivore diets may seem helpful in the short run for people with ME/CFS and long COVID they are not the answer.

GLP-1 agonists like Ozempic could be surprisingly helpful in diseases like chronic fatigue syndrome, fibromyalgia and long COVID.

Researchers assessing T-cell exhaustion in ME/CFS and long COVID could ultimately identify what caused these diseases.

Geoff’s Narrations The GIST The Blog   A trip to Seattle to see Dr. Ruhoy held up the blogs a bit but they’re back! Exercise physiologist Rob Wust’s “Wearable heart rate variability monitoring identif...

Big pharma is largely staying clear of long COVID trials but the many small and some quite large clinical trials are underway provide hope.

The Trump administration pulled the plug on $45 million of long COVID studies and then two days later reversed itself. What the heck is going on?

Post coronavirus vaccination study finds immune breakdowns similar to those found in chronic fatigue syndrome and long COVID

Geoff’s Narrations The Blog The GIST   The GIST is on the bottom right “May you live in interesting times” Apocryphal Chinese curse We’re living in interesting times, that’s for sure. This blog attemp...

A long COVID exercise study finds dramatic muscle abnormalities and sparks some dissent.

Alertness, the ability to carry out tasks, sleep and others in chronic fatigue syndrome are impacted by activation of the default mode network in the brain.