Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

The US Food and Drug Administration (FDA) approved the first oral protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to reduce low-density lipoprotein (LDL) cholesterol. PCSK9 inhibitors have previously been available only as injectable therapies.

Infections may increase the risk of psychiatric and neurological disorders, according to a study published in JAMA Psychiatry.

The American College of Obstetricians & Gynecologists (ACOG) released updated clinical guidance on HIV screening and prevention.

The US Food and Drug Administration (FDA) approved a new subcutaneous starting dosage regimen for the amyloid β-directed antibody lecanemab-irmb, which would allow patients to begin the Alzheimer disease treatment at home.

The US Department of Health and Human Services (HHS) and the Centers for Medicare & Medicaid Services (CMS) announced a new initiative supporting more nutritious hospital meals.

Ischemic heart disease deaths have declined in the US since the 1990s, but they are increasingly attributable to modifiable risk factors such as body mass index (BMI) and hyperglycemia, a study published in JAMA Cardiology found.

This Medical News article is an interview with neurologist Gil Rabinovici, MD, about research presented at the recent Alzheimer’s Association International Conference in London.

This cross-sectional study examines trends in cancer medicine approvals by the US Food and Drug Administration (FDA) for adult solid tumors between 2006 and 2025, including both original and supplemental indication approvals.

The Global Burden of Disease (GBD) 2023 study represents another step in the laudable, collective effort to better understand the causes of health, disease, and mortality around the world in a comprehensive and cohesive manner. The article in this issue of JAMA by the GBD 2023 LDL Cholesterol...

This study examines trends and correlates of current alcohol use, binge drinking, and heavy drinking among pregnant women in the US from 2011 to 2024.

To the Editor Critically ill patients are at risk of distressing symptoms, including pain, agitation, and delirium, which can affect their outcomes.1 Physical restraints may prevent self-extubation and self-harm and protect frontline staff.1

To the Editor Dr Sonneville and colleagues reported that in the R2D2-ICU randomized clinical trial, a restrictive vs liberal physical restraint strategy did not significantly change days alive without coma or delirium through day 14 among critically ill adults.1 This pragmatic study addressed an...

In Reply We thank Drs Tejpal and Sklar for their interest in the R2D2-ICU randomized clinical trial.1 The 2018 Society of Critical Care Medicine clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in...

This Perspective discusses the “iPatient” and “iDoctor,” digital representations of the patient and physician, and the importance of the in-person visit and physical examination in health care settings increasingly using artificial intelligence.

The combustion of millions of gallons of gasoline each year is providing facilities and comfort undreamed of a few decades ago. It has often been remarked that each form of progress is carried out to the detriment of some one. The cost of changes that benefit the many not infrequently involves the...

The enormous development of automobile traffic along rural highways, which includes tourist cars and commercial trucks, has brought about a frightful increase in the number of accidents, which have now reached a much higher figure than those caused by the railways, even as the result of serious...

To the Editor To me, the principal unanswered question raised by the Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV) trial is whether that trial supports use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition...

To the Editor In the VESALIUS-CV trial, Dr Marston and colleagues reported that evolocumab reduced first major adverse cardiovascular events (MACE) in patients with diabetes taking optimized lipid-lowering therapy and without known significant atherosclerosis over 5 years of follow-up.1 While the...

In Reply We appreciate the letters about our recent article.1 However, we disagree with Dr Huang’s characterization of the background lipid-lowering therapy in VESALIUS-CV. A total of 84% of patients were taking statin therapy, which is consistent with reported rates of statin intolerance of...

To the Editor In response to the recent Viewpoint1 on breast density masking and precision screening, we want to highlight the Health Resources and Services Administration (HRSA)–supported Women’s Preventive Services guidelines, which include breast cancer screening for average-risk women. Under...

In Reply I appreciate the response from Mr Engels and colleagues regarding the updated HRSA-supported Women’s Preventive Services guidelines and agree that the updated 2026 policy represents an important but incomplete advance in the completion of screening or diagnostic imaging after mammography....

Government funding for biomedical research is the topic of this Healthy Dialogue conversation between JAMA Senior Editor Derek C. Angus, MD, MPH, and Jeremy Berg, PhD, former editor in chief of Science and former director of the National Institute of General Medical Sciences.

The FaceTime came through my phone,two rectangles of my siblings’ faces.John’s empty.Someone said metastaticand it hovered there like a scanloading too

In “Both Sides of the Bed,” poetry allows clinicians to see their role not as merely technicians but fully embedded caregivers, akin to family members at the bedside.1 Perhaps most striking is the poem’s honesty about the grammar of medicine, how fluently medicalese conjugates suffering in the third...

Patients with cancer are known to have increased rates of pulmonary embolism (PE) from their prothrombotic state, and computed tomographic (CT) pulmonary angiography has long served as the standard diagnostic test when PE is suspected. Professional guidelines and consensus documents have cautioned...

This randomized noninferiority clinical trial evaluates whether the YEARS diagnostic algorithm is as safe and efficient as computed tomographic pulmonary angiography for ruling out pulmonary embolism in patients with active cancer.

Countless hours of development, though those achievements represent only part of the journey. If you want your product to reach healthcare providers across the United States, every stage of development must also satisfy detailed FDA submission requirements through complete, accurate records that explain how the device performs.  The FDA approval process evaluates scientific evidence, testing, […]

Since 2004, public interest in infrared saunas has grown, with online searches related to infrared saunas increasing 500% since 2004. The interest and curiosity have prompted more (though still limited) research. Much of this research relates to traditional sauna bathing. For most healthy adults, moderate use of an infrared sauna (coupled with adequate hydration) is […]

The truth is right out of the gate: Invisalign is effective for many adults but it’s not easy. The aligners should be in your mouth for 20-22 hours each day, only for water, and results will depend on how often the aligners are worn. Once you can establish that habit, and most busy adults can, […]

In this narrative medicine essay, a pediatric hospital medicine and pediatric infectious disease physician stilled by an Achilles tendon rupture compares his wish to expedite healing with pushing early-career physicians, a push that can delay recovery and careers, respectively.

Medical devices and equipment to ensure safety and comfort at home are highly demanded. Such products allow the disabled to be independent and return to their daily life after an operation. Moreover, a person with a particular disease, for example, living with Crohn’s disease, will be able to care for themselves better if they have […]

Do you often feel fatigued for no apparent reason? Do you have recurring brain fog, joint pains, or gastrointestinal issues? The likely culprit is chronic inflammation, a condition that usually presents itself with no obvious signs or symptoms. Chronic inflammation can occur for no apparent reason or can linger after an acute episode of the […]

Ask any charge nurse what happens when a central line cart is missing an introducer kit and you’ll get the same answer every time: the procedure stops. A tech gets sent running to a neighboring unit or someone on the supply chain team is suddenly placing an emergency order at 2 a.m.  “Almost in stock” […]

If your child was hurt during delivery because of a medical mistake, you’ve probably already Googled some version of this question. And honestly, “best” is tricky. It depends on where you live, what happened, and how severe the injury is. A family in Dallas dealing with a cerebral palsy diagnosis needs a very different kind […]

Getting food stuck between your teeth now and then is nothing to stress about. A bit of brushing and flossing usually clears it right up. But if it keeps happening in that one same spot, that is your teeth trying to tell you something. It could be a cavity forming or a filling that has […]

The FDA approved Mimrylo to treat polycythemia vera, a cancer in which overproduction of red cells thickens a patient’s blood.

The drug, called pacibekitug, is one of a number of efforts to tamp down inflammation as a way of improving heart health.

From new hires to departures, promotions and transfers, here are the latest comings and goings in the pharmaceutical industry.

Today's biotech news includes Roivant's autoimmune drug approval, Cytokinetics reports full data for heart condition treatment, and more

The FDA approved Gilead Sciences' once-daily combination pill for treating adults whose HIV infection has fallen to very low levels

The surprise failure of the drug from AstraZeneca and Ionis took a competitor out of the hotly contested ATTR-CM market.

Hospitals are pushing back on Trump's cuts, RFK Jr. confronts measles deaths, Ben Sasse's cancer drug wins approval, and more from STAT's D.C. Diagnosis.