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Complex Multilayer Networks Lab

@comunelab.bsky.social
1.1K followers 70 following 11 posts

Research Group for Multilayer Modeling and Analysis of Complex Systems: from cells to societies. Led by manlius.bsky.social at Dept. of Physics & Astronomy "Galileo Galilei", University of Padua

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Ricard Solé @ricardsole.bsky.social · 07/02/2026
Could the logic of life be shaped by the architecture of biological circuitry? In this paper, @manlius.bsky.social shows how genetic, metabolic, and social networks can govern slow evolutionary dynamics in a unified nonequilibrium framework. iopscience.iop.org/article/10.1...
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Manlio De Domenico @manlius.bsky.social · 04/11/2025
TL;DR: Even the most advanced language models crumble on first-person false beliefs, showing sharp accuracy drops and revealing that their “understanding” of others’ minds is still shallow pattern mimicry, not genuine epistemic reasoning. www.nature.com/articles/s42...
nature.com
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
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Manlio De Domenico @manlius.bsky.social · 06/11/2025
Cooperation isn’t weakness, it’s strategy. Axelrod’s rules remind us: fairness, reciprocity and humility often outcompete envy and cleverness. In complexity, often simplicity wins.
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Manlio De Domenico @manlius.bsky.social · 14/11/2025
Phase transitions, bifurcations, thermal vents, exoplanets and their interactive maps, as well as pointers to a whole special issue just published in @royalsocietypublishing.org about origin of life. With Spotify and Apple podcasts as usual. What do you need more? CC: @ricardsole.bsky.social
manlius.substack.com
When matter came alive: the physics of life’s emergence
Exploring the origins of life through the mathematical theory of transitions
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Manlio De Domenico @manlius.bsky.social · 14/11/2025
Understanding the process that favored the emergence of life is not just about looking backward to 🌎’s first dawn: it’s about learning how complexity itself begins and how it might arise again, elsewhere. Life as a cascade of transitions? #ComplexityThoughts manlius.substack.com/p/when-matte...
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Manlio De Domenico @manlius.bsky.social · 20/11/2025
What a location for a seminar.👀 #ComplexSystems #Padova
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Manlio De Domenico @manlius.bsky.social · 23/11/2025
Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases. www.sciencedirect.com/science/arti... #ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐 🧵 1/
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Manlio De Domenico @manlius.bsky.social · 12/09/2025
A super-interesting new issue of #ComplexityThoughts out! 🧪🌐🧬🌍 🔗 Read: open.substack.com/pub/manlius/... 🎙️ As usual, it’s accompanied by a podcast episode where we explain complex results in a clear, accessible way, almost like “pop science” for complexity: creators.spotify.com/pod/profile/...
open.substack.com
Complexity Thoughts: Issue #67
Unraveling complexity: building knowledge, one paper at a time
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NetSci 2026 @netsciconf.bsky.social · 30/09/2025
📌 Save the Date! The flagship conference of the Network Science Society - 𝗡𝗲𝘁𝗦𝗰𝗶 𝟮𝟬𝟮𝟲 - is coming to Northeastern University’s Network Science Institute, 𝗝𝘂𝗻𝗲 𝟭-𝟱, 𝟮𝟬𝟮𝟲. Prepare to share ideas, discoveries & challenges in network science. Registration opens soon! 🔗 www.netsci2026.com
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Zachary Neal @zpneal.bsky.social · 01/10/2025
Want to promote transparency and clarity in network research by helping develop 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞𝐬 𝐟𝐨𝐫 𝐑𝐞𝐩𝐨𝐫𝐭𝐢𝐧𝐠 𝐀𝐛𝐨𝐮𝐭 𝐍𝐞𝐭𝐰𝐨𝐫𝐤 𝐃𝐚𝐭𝐚 (𝐆𝐑𝐀𝐍𝐃)? Sign up to get involved here: tinyurl.com/help-with-GR... ▪️ All career stages welcome ▪️ All fields welcome ▪️ Be compensated for your time
tinyurl.com
GRAND Recruitment
Complete this short questionnaire to help develop Guidelines for Reporting About Network Data (GRAND).
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Manlio De Domenico @manlius.bsky.social · 01/10/2025
Nearly 4,000 y ago, Egyptians finished their pyramids Meanwhile, across the ocean, termites in NE Brazil were building something even larger: a hidden empire of 200M mounds, over an area the size of UK 🌍🐜 Still active today, a masterpiece of non-human engineering! 🧪🌐 HT @ricardsole.bsky.social
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Ricard Solé @ricardsole.bsky.social · 02/10/2025
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
royalsocietypublishing.org
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936
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Manlio De Domenico @manlius.bsky.social · 02/10/2025
It is often argued that the origin of life must be related to "phase transitions" This concept is often misused, or even abused. In a new paper with @ricardsole.bsky.social we discuss which types of transitions might be involved and some relevant models. royalsocietypublishing.org/doi/full/10....
royalsocietypublishing.org
Bifurcations and phase transitions in the origins of life | Philosophical Transactions of the Royal Society B: Biological Sciences
The path towards the emergence of life in our biosphere involved several key events allowing for the persistence, reproduction and evolution of molecular systems. All these processes took place in a given environmental context and required both molecular ...
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Manlio De Domenico @manlius.bsky.social · 05/10/2025
Between rocky Earths and gas-rich Neptunes, there are worlds that should exist but don’t. Why? New exoplanet surveys reveal how stellar radiation may strip planets bare, showing that our solar system isn’t the rule: maybe it’s the exception. 🧪🌐🪐 www.scientificamerican.com/article/exop...
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Ricard Solé @ricardsole.bsky.social · 09/10/2025
Honored to receive the 2024 Outstanding Publication Award from the Intl Soc for Artificial Life @alife2025.bsky.social for our @royalsocietypublishing.org ublishing.org paper “Fundamental Constraints to the Logic of Living Systems” @sfiscience.bsky.social royalsocietypublishing.org/doi/full/10....
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Manlio De Domenico @manlius.bsky.social · 16/10/2025
Getting ready for a talk. Inspired by the brilliant drawings of @ricardsole.bsky.social, I tried one myself (with a little help from AI). Did I pull it off? What does this image represent?
Pencil sketch of a horned demon conducting symbols of time and physics. A flock of birds flows from a ‘PAST’ side, through a cracked tunnel/bed, toward ‘FUTURE’. Around it: pendulums, clocks, magnets, induction coils, and a solar-system diagram
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Manlio De Domenico @manlius.bsky.social · 19/10/2025
📸 Nearly every dot in this James Webb image isn’t a star: it’s a galaxy, each with billions of stars and even more worlds. And this? It’s just a tiny corner of the observable universe. A short thread 🧵1/
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Manlio De Domenico @manlius.bsky.social · 22/10/2025
In the '30s of the past century, the Sicilian physicist Ettore Majorana wrote an article about the value of statistical laws in physics and in social sciences. A pioneering non-technical work. I am wondering if successive ('40s-'50s) “sociophysics” papers are related. arxiv.org/abs/0709.3537
arxiv.org
L'articolo di Ettore Majorana su "Il valore delle Leggi Statistiche nella Fisica e nelle Scienze Sociali" (Ettore Majorana's article on "The value of Statistical Laws in Physics and in Social Sciences...
The mentioned article was written by Ettore Majorana, in a partially educational way, for a journal of Sociology; but he gave up publishing it (and threw it away). It appeared posthumous, thanks to Gi...
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Manlio De Domenico @manlius.bsky.social · 23/10/2025
“we might add “natural cooperation” as a third fundamental principle of evolution beside mutation and natural selection” 🧪 #ComplexSystems #Evolution www.science.org/doi/pdf/10.1...
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Complex Multilayer Networks Lab @comunelab.bsky.social · 25/10/2025
Due update to the lab 📸 Hello world!
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Complex Multilayer Networks Lab @comunelab.bsky.social · 03/10/2025
Welcome @valedand.bsky.social to BlueSky! If you are interested in biological complexity, computational neuroscience and population dynamics (eg epidemics) click on the follow button 🧠🦠!
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Manlio De Domenico @manlius.bsky.social · 30/09/2025
🚨 Thrilled to release the official repository of the @comunelab.bsky.social! It centralizes access to decade-long research outputs, including 57 data sets and 22 code libraries. A titanic effort: 28,000 lines of code We hope to accelerate #openScience in #ComplexSystems 👉 github.com/CoMuNeLab
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Manlio De Domenico @manlius.bsky.social · 03/06/2025
Physical devices operating out of equilibrium are affected by thermal fluctuations, limiting their operational precision Coherent quantum dynamics can surpass the traditional thermodynamic precision limits, guiding development of future high-precision quantum devices www.nature.com/articles/s41...
nature.com
Precision is not limited by the second law of thermodynamics - Nature Physics
Clock precision is thought to be fundamentally limited by entropy production in out-of-equilibrium systems. A theoretical work now introduces a quantum clock design where precision grows exponentially...
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Manlio De Domenico @manlius.bsky.social · 13/06/2025
🚨 A new work from an international collaboration with the great @yuetinghan.bsky.social, Paolo Turrini, Marya Bazzi, @giuliandr.bsky.social & Eugenia Polizzi Measuring the co-evolution of online engagement with (mis)information and its visibility at scale 👉 arxiv.org/abs/2506.06106 Short 🧵 1/
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Manlio De Domenico @manlius.bsky.social · 12/06/2025
🚨 New paper from @comunelab.bsky.social ! We review the latent geometry emerging from network-driven processes, with an eye to network functionality and applications from biological systems to infrastructures. 👉 arxiv.org/abs/2506.09616 #ComplexSystems #NetworkScience 🧪🌐 Short 🧵 1/
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Manlio De Domenico @manlius.bsky.social · 02/06/2025
It was a pleasure to lecture at the @netsciconf.bsky.social for an interested & interactive audience. What's a model? Why do we model? Is our network a network? Can we restore broken and forgotten links? I will post on #ComplexityThoughts about this lecture, which I have enjoyed to prepare. 🧵 1/
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Manlio De Domenico @manlius.bsky.social · 02/06/2025
I own a math proof for a slides to a young network scientist attending my lecture this morning. I promised the proof at the end of the talk, but it was lunchtime and we missed the chance to discuss. Can you help me to find/reach him? 🙏 Tomorrow, 10:35, FSE C1.005 at PHS1 @netsciconf.bsky.social
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Manlio De Domenico @manlius.bsky.social · 03/06/2025
The joint prob that you are in Maastricht and you still don't which satellite to attend is nearly zero. But still, you can show up to our MIX-NEXT if you are curious about where the field is going and what we can do to make it happen. Scales, structure, dynamics, information #NetSci20025
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Manlio De Domenico @manlius.bsky.social · 12/05/2025
"the concept of the formose reaction as a prebiotic source of ribose on early Earth needs serious reconsideration, and other models/options should be explored" #OoL #OriginOfLife 🧪🧬 www.cell.com/chem/abstrac...
cell.com
Abiotic aldol reactions of formaldehyde with ketoses and aldoses—Implications for the prebiotic synthesis of sugars by the formose reaction
The formose reaction is proposed to produce sugars of relevance to biomolecules (RNA). By 13C-NMR, the aldol reactions of formaldehyde are shown to proceed to form linear and finally branched ketoses....
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Manlio De Domenico @manlius.bsky.social · 19/05/2025
“The view from my window” – Cassini-Huygens spacecraft It's so reassuring that that little, pale, blue dot it's us, about 1 billion km away.
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Complex Multilayer Networks Lab @comunelab.bsky.social · 15/05/2025
From ecology to epi, from resilience to climate change, the members of our lab will present several results at the next @netsciconf.bsky.social, while @manlius.bsky.social will give a lecture about the broken, lost and future links in #NetworkScience Let's meet in Maastricht & let's get in touch!
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Manlio De Domenico @manlius.bsky.social · 04/05/2025
The internet is one of the greatest achievements of humankind. Yet, we didn't learn how to use it, especially since we give for granted that it has almost zero cost, like natural resources. Well, indeed it does cost, a lot. And we should learn how to get the most at minimum collateral effects.
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Manlio De Domenico @manlius.bsky.social · 03/05/2025
Do you know what's inside an ant nest? It is possible to unravel its hidden organization into an intricate web of tunnels: a complex "city" emerges. #ComplexSystems 🧪🐜🐜🐜🐜 youtu.be/dECE7285GxU?...
youtu.be
Secret Megalopolis of Ants Uncovered - Truly a Wonder of the World !
YouTube video by wocomoWILDLIFE
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Manlio De Domenico @manlius.bsky.social · 05/05/2025
Glad to see that our recent paper on digital twins for biomedical systems aligns with this view: simple correlational data cannot be used for digital twins and, accordingly, for building decisions. www.nature.com/articles/s41...
nature.com
Challenges and opportunities for digital twins in precision medicine from a complex systems perspective - npj Digital Medicine
npj Digital Medicine - Challenges and opportunities for digital twins in precision medicine from a complex systems perspective
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Konrad Kording @kordinglab.bsky.social · 08/05/2025
Nice write up on the consciousness IIT gwt debate. And huge fan of adversial collaboration. Although the problem here is that it was a collaboration between two overambitious theories. The right adversarial would have been convinced that such theories can not currently exist.
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Manlio De Domenico @manlius.bsky.social · 07/05/2025
This highlights how a strong mutualistic interaction can promote the diversification of entire clades by influencing their phenotypes, defining their geographic distribution, and ultimately contributing to their evolutionary and ecological success 🧪🧬🐠 www.pnas.org/doi/10.1073/...
pnas.org
Host use drives convergent evolution in clownfish | PNAS
Clownfishes (Amphiprioninae) are a fascinating example of a marine radiation. From a central Pacific ancestor, they quickly colonized the coral ree...
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Manlio De Domenico @manlius.bsky.social · 08/05/2025
(Trying to) Measuring consciousness in the lab? The latest essay from #ComplexityThoughts feat. @wiringthebrain.bsky.social & @kordinglab.bsky.social to discuss about consciousness and how to define/measure it: 👉 open.substack.com/pub/manlius/... 🎧 creators.spotify.com/pod/show/com... 1/
open.substack.com
(Trying to) Measuring consciousness in the lab
What did we learn from a rigorous adversarial test?
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Manlio De Domenico @manlius.bsky.social · 12/05/2025
"we emphasize how a characterization of the unpredictability of a system gives a measure of its complexity. Adopting this point of view, we review some developments in the characterization of the predictability of systems showing different kinds of complexity"🧪 www.sciencedirect.com/science/arti...
sciencedirect.com
Predictability: a way to characterize complexity
Different aspects of the predictability problem in dynamical systems are reviewed. The deep relation among Lyapunov exponents, Kolmogorov–Sinai entrop…
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Manlio De Domenico @manlius.bsky.social · 12/05/2025
"It is shown that a dynamical system subject to both periodic forcing and random perturbation may show a resonance (peak in the power spectrum) which is absent when either the forcing or the perturbation is absent" The stochastic resonance! #ComplexSystems 🧪 iopscience.iop.org/article/10.1...
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Manlio De Domenico @manlius.bsky.social · 14/05/2025
Preparing my next @netsciconf.bsky.social School lecture. There are several #ComplexityThoughts I'll unpack across 2.5 hours (and many liquids). 💡 One spoiler: all unreliable networks are alike; each reliable network is reliable in its own way. See you in Maastricht. #NetSky
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Manlio De Domenico @manlius.bsky.social · 08/05/2025
Thrilled for the latest work from @comunelab.bsky.social ! We introduce a multilayer + multiscale model in two distinct frameworks (particle- & force-based), identifying how to balance contact and mobility cuts to mitigate epidemics. #ComplexSystems www.sciencedirect.com/science/arti... 🧪🦠
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Manlio De Domenico @manlius.bsky.social · 04/04/2025
Latest #ComplexityThoughts just out: Issue #57 Network reconstruction (well done), a special about #fungi, #evolution and #Neuroscience this week 🍄🧠🧬🦠🧫🧪🌐 Podcast available on Spotify and Apple as usual. Enjoy and have a nice weekend with #ComplexSystems! open.substack.com/pub/manlius/...
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Manlio De Domenico @manlius.bsky.social · 08/04/2025
New #ComplexityThoughts out there, about the resurgence of measles in the U.S. Post: open.substack.com/pub/manlius/... 👉 With links to interactive experiments to better understand the complexity behind this process. 🎧 creators.spotify.com/pod/show/com... (also available via Apple) #EpiSky
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Manlio De Domenico @manlius.bsky.social · 09/04/2025
Using 🐁watching "The Matrix", scientists have reconstructed the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue. 82k neurons, 500 million synapses #Neuroscience 🧪🧠 www.nature.com/articles/s41...
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Manlio De Domenico @manlius.bsky.social · 09/04/2025
As we enter an era marked by multipolar power dynamics, shifting alliances and institutional stress, the possibility of sudden breakdowns in global governance becomes real. New #ComplexityThoughts: open.substack.com/pub/manlius/... 🎧 creators.spotify.com/pod/show/com...
open.substack.com
Fragile balances: understanding global stability
Predicting the fate of world order using a toy model
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Manlio De Domenico @manlius.bsky.social · 10/04/2025
Wherever we find orderly, stable systems in Nature, we find that they are hierarchically structured, for the simple reason that w/o such structuring of #ComplexSystems into sub-assemblies, there could be no order and stability-except the order of a dead universe filled with [..] gas. #booksky
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Manlio De Domenico @manlius.bsky.social · 10/04/2025
Functional organization derived from network-driven processes offers clear advantages wrt traditional methods when studying human brain networks, outperforming SoTA communication models in explaining functional communities from structural data. #Neuroscience 🧪🧠 www.pnas.org/doi/10.1073/...
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Ricard Solé @ricardsole.bsky.social · 14/04/2025
How did life emerge in our biosphere? An important part of our understanding of this might be grounded in the physics of phase transitions and the maths of bifurcation theory. Here's our review paper with @manlius.bsky.social arxiv.org/pdf/2504.08492
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Manlio De Domenico @manlius.bsky.social · 18/04/2025
🚨 A new #ComplexityThought essay is out! I report the recent studies about convergent evolution observed in brain systems, and include a broader vision thanks to a discussion with @ricardsole.bsky.social Podcast: creators.spotify.com/pod/show/com... open.substack.com/pub/manlius/...
open.substack.com
Different paths, same functions: the convergence of neural circuits
The inevitable emergence of good solutions?
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Manlio De Domenico @manlius.bsky.social · 04/04/2025
"The approach developed here provides a framework for linking microbial traits to Earth’s geochemical history, offering a pathway for exploring the evolution of other phenotypes in the context of Earth’s history" #ComplexSystems #evolution 🧪🦠🌎🌐 www.science.org/doi/10.1126/...
science.org
A geological timescale for bacterial evolution and oxygen adaptation
Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the ge...
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