Among the ways by which oncogenic KRAS upregulates glycolysis in cancer is direct interaction of KRAS4A with hexokinase 1 (HK1), but the mechanism is …

Kochen Rossi et al. performed proximity labeling using the two splice variants of KRAS and defined their differential interactomes. Among the KRAS4A-specific interactors is BIRC6, a large member of the inhibitor of apoptosis proteins. BIRC6 co-localizes with KRAS4A on the Golgi and mono- and di-ubiquitinates KRAS4A but not KRAS4B.