Our preprint led by Nicole Michmerhuizen and Emily Heikamp showing the key role and targetability of the MOZ/MORF history acetyltransferases in high-risk NUP98-rearranged acute myeloid leukemia.
www.biorxiv.org/content/10.1...
biorxiv.org
MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML) and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However,...
