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Clinical Toxicology

@clinicaltoxicology.bsky.social
195 followers 12 following 264 posts

Official journal of American Academy of Clinical Toxicology, America's Poison Centers, and the European Association of Poisons Centres and Clinical Toxicologists. www.tandfonline.com/journals/ictx20

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Clinical Toxicology @clinicaltoxicology.bsky.social · 15/10/2026
The North American Congress of Clinical Toxicology (NACCT) 2026 abstracts can be found here! www.tandfonline.com/doi/full/10....
tandfonline.com
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this study of data from the French Poison Centres Network, the effect of the COVID-19 pandemic/lockdowns and school terms on trends in adolescent/child self-poisoning were examined www.tandfonline.com/doi/full/10....
tandfonline.com
Link between paediatric suicidal poisonings and school calendar: a national French Poison Centres study
Calls to French Poison Centres reflected the observed increase in attempted suicides during the COVID-19 pandemic, especially among adolescent girls and young women. We aim to investigate, through ...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
A 58-year-old man received one gram of ferric carboxymaltose. Eight hours post-infusion, the patient developed tachypnea, abdominal pain, high anion gap lactic acidosis, serum iron of 144 micromol/L. The patient was treated with deferoxamine www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
A 65-year-old woman developed severe lacosamide intoxication. High-flux hemodialysis appeared to have provided incomplete drug removal, so there was escalation to high-flux hemodiafiltration. The patient showed neurological improvement www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
A 72-year-old woman developed serotonin toxicity after tramadol was re-escalated to her baseline dose while taking newly initiated nefopam. Symptoms resolved within 24 hours after discontinuation of both medications www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
A 56-year-old man presented with nine days of worsening right thigh swelling. Labs showed INR of 9.05 and serum brodifacoum concentration of 25 mcg/L. Imaging showed a large intramuscular thigh hematoma. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective study, 51 patients with presumed Datura poisoning were evaluated. Symptom onset most commonly included dry mouth, vertigo, inebriation, and gastrointestinal symptoms. Toxicity was mild to moderate and all patients recovered completely www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this experimental in vitro study, the physicochemical mechanisms of intravenous fat emulsion drug extraction was evaluated for seven drugs: bromazepam, bupivacaine, diphenhydramine, mepivacaine, quetiapine, paracetamol, and verapamil www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this study, severe-to-fatal hydrogen sulfide poisoning was associated with working in confined workplaces/underground environments, initial metabolic acidosis, and pulmonary infiltrates www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective study of poison centre data from four European countries, one in ten cases involved deliberate self- poisoning. Paracetamol and ibuprofen were common substances among 5-17 year-olds www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective cross-sectional study of Daboia siamensis snake bites, local effects were uncommon but systemic effects (such as hematotoxicity and nephrotoxicity) were developed one day after being bitten. www.tandfonline.com/doi/full/10....
tandfonline.com
Siamese Russell’s viper bite: epidemiology, clinical characteristics, and outcomes
Daboia siamensis envenoming is a major cause of hematotoxicity and acute kidney injury in Southeast Asia. In Thailand, D. siamensis is a clinically important snake, yet detailed national data on it...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective study of 21 patients with chlorfenapyr poisoning, fatal chlorfenapyr poisoning was characterized by a latency period followed by a hypermetabolic state www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this review of patients treated in a hyperbarics facility, the incidence of delayed neurological sequelae were found to be different depending on the treatment regimen, with a PO2 of 2.8ATA being associated with superior neuroprotective outcomes. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective cohort study, 50 patients with either cannabinoid hyperemesis syndrome or acute cannabis intoxication had serum cannabinoid analysis using liquid chromatography-tandem mass spectrometry. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective study, 599 comatose adults with benzodiazepine or nonbenzodiazepine hypnotic poisoning were propensity-matched to evaluate flumazenil treatment. Flumazenil-treated patients had lower rates of ICU admission and mechanical ventilation www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
In this retrospective study, 84 children with colchicine poisoning were evaluated for dose-related toxicity and outcomes, with higher ingested doses associated with cardiovascular involvement and diarrhea associated with cardiovascular complications. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
This narrative review summarizes the acute cardiovascular complications of sympathomimetic recreational drugs, including cocaine, amphetamine-type stimulants, and synthetic cathinones www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 02/10/2026
This commentary by Su et al examines diagnostic uncertainty in toxicology, the absence of definitive diagnostic gold standards, and the ambiguity encountered within the practice of toxicology www.tandfonline.com/doi/full/10....
tandfonline.com
Dealing with diagnostic bias and uncertainty: What is the burden of proof in toxicology?
Published in Clinical Toxicology (Vol. 64, No. 10, 2026)
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Clinical Toxicology @clinicaltoxicology.bsky.social · 24/09/2026
Clinical Toxicology is recruiting a Reviews Editor: a clinical/medical toxicologist with a strong clinical research background, and the commitment and drive to help develop the Journal. Application deadline Nov 4th. Details: editorresources.taylorandfrancis.com/editor_recru...
editorresources.taylorandfrancis.com
Reviews Editor needed for Clinical Toxicology – Editor Resources
Editor Resources provides insights and information to support the editor’s role and build connections between journal editors and research communities.
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Case report: Survival despite extreme methemoglobinemia (92.5%) following sodium nitrite ingestion. www.tandfonline.com/doi/full/10....
tandfonline.com
Survival from extreme methemoglobinemia due to intentional sodium nitrite poisoning
Published in Clinical Toxicology (Vol. 64, No. 9, 2026)
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Report: Rhabdomyolysis, renal failure and chronic neurologic deficits after prolonged immobilization from use of a 7-hydroxymitragynine product. www.tandfonline.com/doi/full/10....
tandfonline.com
Rhabdomyolysis, renal failure and chronic neurologic deficits after prolonged immobilization from use of a 7-hydroxymitragynine product
Published in Clinical Toxicology (Vol. 64, No. 9, 2026)
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Portal venous gas after ingestion of concentrated hydrogen peroxide www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In acute thallium poisoning, neuropathic pain and numbness can precede alopecia; nerve damage may persist a year later despite treatment. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Blood transfusion can confound alcohol monitoring: after just one unit of packed RBCs, 8% of patients crossed from negative to positive on phosphatidylethanol testing, despite no evidence of alcohol use. www.tandfonline.com/doi/full/10....
tandfonline.com
Packed red blood cell transfusion affecting phosphatidylethanol concentration
Toxicologists are often called upon to interpret results of drug testing. Phosphatidylethanol is a biomarker sensitive for ethanol consumption within the previous one to four weeks and is commonly ...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
After large bupropion overdoses, tablets may remain in the stomach for hours: 60% had drug material at endoscopy, rising to 73% after ≥30 tablets. Endoscopic removal was successful in all positive cases. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
British ambulance services rely heavily on poison information: 227,000 TOXBASE searches in one year, while poison center advice allowed about 1 in 4 callers to avoid further care. www.tandfonline.com/doi/full/10....
tandfonline.com
Ambulance services’ use of poison information in Great Britain – a retrospective records analysis of calls and TOXBASE® accesses
Poison information centres advise health professionals on toxic exposures and recommend appropriate responses, preventing transfer where hospital treatment is not required. No study to date has det...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Daily rather than weekly methotrexate can be dangerous: 57% developed organ toxicity, usually mucositis, and two died. Toxicity occurred after relatively low doses and short dosing errors. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In France, only 19 intentional xylazine poisonings were reported over 14 years. Most were suicide attempts; just one involved recreational use. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Could saliva replace urine for drug monitoring? In this pilot study, oral fluid testing showed >88% agreement with urine, and patients overwhelmingly preferred it. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In a randomized pilot study of krait bites causing neuroparalysis, 10 vials of antivenom performed similarly to 20, suggesting the routinely recommended second dose may often be unnecessary. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In selected low-risk acetaminophen overdoses, stopping acetylcysteine after 12 hours instead of 20 produced no increase in liver injury, even using sensitive acetaminophen-protein adducts as a marker. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Henbane poisoning produced a classic antimuscarinic toxidrome in 68 children, but severe cases were striking: 36% had seizures and 68% developed acute kidney injury. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Diquat is strikingly neurotoxic: 35% of 129 poisoned patients developed toxic encephalopathy, most often involving the brainstem. Of those, 60% died. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Among nearly 60,000 European ED presentations for recreational drug toxicity, 23% had cardiovascular effects, and their presence was associated with 16-fold higher odds of death. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Which drugs are most likely to cause seizures in overdose? Bupropion (24%) and mefenamic acid (15%) stood out in this analysis of >20,000 single-drug poisonings. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In 77 single-agent mifepristone exposures, effects were generally mild: no major outcomes, including no reported fetal deaths among eight pregnant patients. www.tandfonline.com/doi/full/10....
tandfonline.com
Clinical outcomes of single-agent mifepristone exposures reported to US Poison Centers: a ten-year review of the National Poison Data System® (2015–2024)
Mifepristone is a 19-nor steroid that functions as a progesterone and glucocorticoid receptor antagonist with multiple uses approved by the United States Food and Drug Administration. Although its ...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Enhanced follow-up improved poison-centre outcome data, but was labor-intensive: each case required nearly 3 follow-up calls and 21 minutes of specialist time on average. www.tandfonline.com/doi/full/10....
tandfonline.com
A characterisation of one year of enhanced enquiry follow-up from a United Kingdom poison centre
United Kingdom poison centres handle 40,000 telephone enquiries annually, and of these, follow-up is required for enquiries with a ‘severe’ Poisoning Severity Score or where requested by a clinical...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Among 744 accidental pediatric factor Xa inhibitor ingestions, none resulted in bleeding, including one reported ingestion of up to 500 mg rivaroxaban. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Among young children brought to the ED for poison exposures, 65% could have been managed without an ED visit. www.tandfonline.com/doi/full/10....
tandfonline.com
Assessing unnecessary emergency department visits for poison exposures in pediatric patients less than six years old
We will investigate the medical necessity of pediatric emergency department presentations, specifically for emergency department poison cases where a poison control center was not contacted prior t...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
In 105 viper bites from southwest China, higher neutrophil counts and lower lymphocyte counts tracked most strongly with envenomation severity. www.tandfonline.com/doi/full/10....
tandfonline.com
Correlation between laboratory indicators and severity of viper snakebite and limb swelling: a retrospective study in southwestern China
Snakebite envenomation remains a significant public health concern, with viper bites in southwestern China posing substantial clinical challenges due to complications such as coagulopathy and tissu...
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Aspiration-related lung injury complicated 6.8% of acute drug/ethanol poisonings. Fever was the strongest predictor (OR 39), along with dysrhythmia, respiratory insufficiency and sedation. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
The slow loris is the only venomous primate. In this 28-patient series, 43% of bites caused anaphylaxis and 29% anaphylactic shock. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
What should new medical toxicology fellows actually learn first? A Delphi panel prioritized 30 essential topics, and a redesigned 2-week orientation boosted knowledge scores from 64% to 93%. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 10/09/2026
Iatrogenic acetylcysteine overdose is rare but can be catastrophic. This scoping review found that very large exposures (≥1000 mg/kg) were associated with cerebral edema, sometimes complicated by death. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
An 86-year-old opioid-naïve woman presented with delayed respiratory depression after receiving low-dose oxycodone while taking adagrasib, a CYP3A and CYP2D6 inhibitor. Naloxone was given and promptly reversed the respiratory depression. www.tandfonline.com/doi/full/10....
tandfonline.com
Opioid toxicity from impaired oxycodone metabolism associated with adagrasib
Published in Clinical Toxicology (Vol. 64, No. 8, 2026)
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
A 16-year-old female presented after ingestion of approximately twenty extended-release lithium carbonate tablets. Despite initially negative abdominal radiographs, abdominal CT demonstrated 20 radiopaque tablets in the small bowel. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
A 46-year-old woman presented after ingestion of fenitrothion and malathion and developed abdominal distension. Abdominal CT showed pneumatosis intestinalis and portal venous gas. Emergent laparotomy was performed but no necrosis was seen. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
This laboratory analysis of five retail products marketed as containing kava identified kratom alkaloids, including mitragynine pseudoindoxyl, in multiple products. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
This lab study evaluated the adsorption capacity of activated charcoal for five metal ions (lead/thallium/cesium/rubidium/lithium) and found adsorption of all tested metal ions except lithium ions, with lead demonstrating the greatest adsorption capacity. www.tandfonline.com/doi/full/10....
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Clinical Toxicology @clinicaltoxicology.bsky.social · 03/08/2026
This retrospective study of 20,176 single-agent pharmaceutical exposures found that seizures occurred in 1.2% of cases. Mefenamic acid (15.7%), quetiapine (10%), and bupropion (10%) were most commonly associated with seizures. www.tandfonline.com/doi/full/10....
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