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CIRTN-R2FIC

@cirtn.bsky.social
82 followers 27 following 176 posts

We are the Canadian Islet Research and Training Network / Réseau de researche et formation sur les îlots du Canada. Find out more at Islets.ca Note: Account is primarily run by the volunteer trainee committee.

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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Shapiro: “Outcomes Following Total Pancreatectomy With and Without Vascular Resection: A NSQIP Analysis Comparing Trends in Patient Selection and Outcomes Over 5 Years” PMID: 42609030 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Outcomes Following Total Pancreatectomy With and Without Vascular Resection: A NSQIP Analysis Comparing Trends in Patient Selection and Outcomes Over 5 Years
Introduction Advances in neoadjuvant therapy and surgical techniques have led to more total pancreatectomies (TP) with vascular resection for pancreatic cancer. This study assesses contemporary outc...
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Rabasa-Lhoret: “Prandial Insulin Adjustments in the Context of Gastroparesis and Type 1 Diabetes: A Mixed-Methods Study” PMID: 42637002 www.canadianjournalofdiabetes.com/article/S149...
canadianjournalofdiabetes.com
Prandial Insulin Adjustments in the Context of Gastroparesis and Type 1 Diabetes: A Mixed-Methods Study
Gastroparesis (impaired gastric motility) is a complication of type 1 diabetes that affects glycemic management. Yet, little research exists on prandial insulin adjustment strategies to manage this co...
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Rabasa-Lhoret: “Physical and psychosocial complications faced by postmenopausal women with type 1 diabetes: a cross-sectional BETTER analysis” PMID: 42551704 www.diabetesresearchclinicalpractice.com/article/S016...
diabetesresearchclinicalpractice.com
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Rabasa-Lhoret: “Identification of Activity, Insulin, and Dietary Thresholds Associated With Exercise-Related Hypoglycaemia and Hyperglycaemia in Children With Type 1 Diabetes[...]” PMID: 42543251 dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com
Identification of Activity, Insulin, and Dietary Thresholds Associated With Exercise‐Related Hypoglycaemia and Hyperglycaemia in Children With Type 1 Diabetes: A Free‐Living Study Using Explainable Machine Learning
Aims Some studies have explored associations between physical activity (PA) and hypoglycaemia in real-life in type 1 diabetes (T1D) but without fully accounting for two major confounders, diet and i...
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Prentki: “Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health” PMID: 42675085 www.nature.com/articles/s41...
nature.com
Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health - Nature Communications
Selective hepatic insulin resistance contributes to the development of metabolic disease, but the molecular mechanisms \remain unclear. Here, the authors identify a nonenzymatic role for ABHD6 in prom...
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Lim: “β-cell 14-3-3-ζ and sex are key regulators of α-cell form and function” PMID: 42644279 academic.oup.com/endo/advance...
academic.oup.com
β-cell 14-3-3-ζ and sex are key regulators of α-cell form and function
Abstract. α-cells exhibit heterogeneity in their hormone production, whereby distinct α-cell subpopulations can be induced to produce active glucagon-like
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Drs. Pepper and Korbutt: “Nanofibrous Bioabsorbable Functionalized Scaffolds Augment Subcutaneous Islet Engraftment and Function in Mice” PMID: 42240469 diabetesjournals.org/diabetes/art...
diabetesjournals.org
Nanofibrous Bioabsorbable Functionalized Scaffolds Augment Subcutaneous Islet Engraftment and Function in Mice
The subcutaneous (SQ) space is a promising site for islet transplantation to treat type 1 diabetes. We hypothesize that nanofibrous bioabsorbable functiona
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Hill: “Vitamin D Deficiency During Pregnancy Is Associated With Greater LDL-C Increase, Elevated β-Hydroxybutyrate and Altered Neonatal Metabolic Markers [...] Gestational Diabetes Prevention Trial (DALI)” PMID: 42594354 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Vitamin D Deficiency During Pregnancy Is Associated With Greater <fc>LDL</fc>‐C Increase, Elevated β‐Hydroxybutyrate and Altered Neonatal Metabolic Markers—A Secondary, Pooled Analysis of the Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (<fc>DALI</fc>)
Early pregnancy vitamin D deficiency in women with overweight or obesity is associated with greater increases in LDL cholesterol and ketone bodies during gestation, as well as higher cord blood keton...
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Dhavantari: “Stathmin-2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1-6 cells” PMID: 42625306 physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Stathmin‐2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1‐6 cells
Abstract figure legend Paracrine regulation of glucagon involves Stathmin2-mediated trafficking of glucagon through lysosomal transport. Glucagon secretion is regulated by the paracrine hormones insu....
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
August 2026: From Dr. Devlin: “Expert Perspectives on Diagnosis and Management of Vitamin B12 Deficiency in Adults” PMID: 42641763 www.sciencedirect.com/science/arti...
sciencedirect.com
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CIRTN-R2FIC @cirtn.bsky.social · 22/09/2026
The final recap of CIRTN Summer 2026 publications: August🌻! Here are works from the labs of Drs. Devlin, Dhavantari, Hill, Korbutt, Pepper, Lim, Prentki, Rabasa-Lhoret and Shapiro.
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵9/9) CIRTN Summer Publications July 2026. From Dr. Riddell: “Exercise Snacks Are Feasible to Perform in the Real World and Improve Physical Capacity for Adults Living With Non-Insulin Treated Type 2 Diabetes: A Randomised Trial” PMID: 42502209 dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com
Exercise Snacks Are Feasible to Perform in the Real World and Improve Physical Capacity for Adults Living With Non‐Insulin Treated Type 2 Diabetes: A Randomised Trial
Aims To investigate the feasibility and preliminary efficacy of a 12-week remotely-delivered exercise snacks (ES) intervention in adults with type 2 diabetes. Material and Methods Insufficiently ac.....
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵8/9) CIRTN Summer Publications July 2026. From Dr. Rabasa-Lhoret: “TyG-derived anthropometric indices as surrogate markers of insulin resistance compared with the hyperinsulinemic-euglycemic clamp” PMID: 42501895 www.sciencedirect.com/science/arti...
sciencedirect.com
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵7/9) CIRTN Summer Publications July 2026. From Dr. Prentki: “Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess” PMID: 42413493 www.cell.com/cell-metabol...
cell.com
Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess
Challenging dogmas, Prentki et al. propose an alternative paradigm of obesity-related type 2 diabetes, interpreting insulin resistance, reduced glucose-induced insulin secretion, mild hyperglycemia, a...
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵6/9) CIRTN Summer Publications July 2026. From Dr. Mulvihill: “Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency” PMID: 42402309 www.jmcc-online.com/article/S002...
jmcc-online.com
Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency
Heart failure arises when persistent cardiac stress drives maladaptive remodeling and fibrosis. Plasminogen activator inhibitor-1 (SERPINE1/PAI-1) acts as a repressor of cardiac fibrosis (CF). While c...
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵5/9) CIRTN Summer Publications July 2026. From Dr. Light: “Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation” PMID: 42464877 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵4/9) CIRTN Summer Publications July 2026. From Dr. Light: “Residue-level insights into SGLT2 inhibition and Nav1.5 selectivity of gliflozin derivatives: A molecular dynamics and pharmacophore-guided study” PMID: 42398488 www.sciencedirect.com/science/arti...
sciencedirect.com
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵3/9) CIRTN Summer Publications July 2026. From Drs Kolic and Johnson: “Nutrient and non-nutrient regulators of insulin secretion” PMID: 42469413 www.nature.com/articles/s41...
nature.com
Nutrient and non-nutrient regulators of insulin secretion - Nature Reviews Endocrinology
This Review explores the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors. An improved understanding of the complexities of how insulin secretion is ...
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵2/9) CIRTN Summer Publications July 2026. From Dr. Ferdaoussi: “The Edmonton transplantation protocol, 25 years later: toward remission of type 1 diabetes?” PMID: 42466693 publications.edpsciences.org/10.1051/meds...
publications.edpsciences.org
Le protocole de transplantation d’Edmonton, 25 ans plus tard : vers la rémission du diabète de type 1 ? | médecine/sciences
m&eacute;decine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, m&eacute;dicale et en sant&eacute;
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CIRTN-R2FIC @cirtn.bsky.social · 15/09/2026
(🧵1/9) CIRTN Summer Publications Part 2: July☀️! Here are works from the labs of Drs. Ferdaoussi, Kolic, Johnson, Light, Mulvihill, Prentki, Rabasa-Lhoret and Riddell.
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵17/17) June 2026: From Dr. Rutter: “Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells” PMID: 42337344 www.nature.com/articles/s42...
nature.com
Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells - Communications Biology
High spatiotemporal resolution imaging of pancreatic slices from GluCre:GCaMP6f mice reveals Ca²⁺ dynamics in α-cells and neighboring β- and δ-cells, uncovering sex-dependent differences in α-cell res...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵16/17) June 2026: From Dr. Rutter: “Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion” PMID: 42329762 www.cell.com/cell-reports...
cell.com
Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion
Trimigliozzi et al. show that α-cells integrate neuronal and immune signals to release glucagon, which acts on β-cell glucagon and GLP-1 receptors to drive insulin secretion at fasting glucose concent...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵15/17) June 2026: From Dr. Rutter: “AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes” PMID: 42327161 www.biorxiv.org/content/10.6...
biorxiv.org
AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes
Human pancreatic islets exhibit greater anatomic and cellular heterogeneity than previously appreciated, raising fundamental questions about how their composition varies with age, sex, region, and isl...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵14/17) June 2026: From Drs Rideout and Johnson: “Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience” PMID: 42330305 diabetesjournals.org/diabetes/art...
diabetesjournals.org
Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience
As the sole source of circulating insulin in the body, β-cells synthesize up to ∼5,000 insulin molecules per second (1). This enormous burden on β-cell pro
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵13/17) June 2026: From Dr. Riddell: “Percent Time Below Range Is Strongly Associated with Clinically Important Level 2 Hypoglycemia Events in Individuals with Type 1 Diabetes” PMID: 42333068 journals.sagepub.com/doi/10.1177/...
journals.sagepub.com
Percent Time Below Range Is Strongly Associated with Clinically Important Level 2 Hypoglycemia Events in Individuals with Type 1 Diabetes - Peter Calhoun, Richard T. Liggins, Zoey Li, Michael C. Ridde...
Objective: To evaluate the relationship between continuous glucose monitoring (CGM)-measured % time <54 mg/dL (%T < 54) and level 2 hypoglycemic events (L...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵12/17) June 2026: From Dr. Riddell: “One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin-Induced Hypoglycaemia and Does Not Worsen Glycemia ...” PMID: 42315494 dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com
One Week Exposure to a Somatostatin Receptor 2 Antagonist (<fc>SSTR2a</fc>) Enhances Glucagon Counterregulation to Insulin‐Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin‐Requiring Type 2 Diabetes
Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin-treated type 2 diabetes (T2D), but the durability of this e...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵11/17) June 2026: From Dr. Riddell: “Factors Associated With Nocturnal Hypoglycemia After Exercise in the Type 1 Diabetes and Exercise Initiative (T1DEXI) PMID: 42247270 diabetesjournals.org/care/article...
diabetesjournals.org
Factors Associated With Nocturnal Hypoglycemia After Exercise in the Type 1 Diabetes and Exercise Initiative (T1DEXI)
OBJECTIVE. To identify modifiable factors associated with postexercise nocturnal hypoglycemia in the Type 1 Diabetes and Exercise Initiative (T1DEXI) study
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵10/17) June 2026: From Dr. Rabasa-Lhoret: “The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state ...” PMID: 42262529 link.springer.com/article/10.1...
link.springer.com
The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state in adults with ...
Aims/hypothesis The objective of this randomised crossover study was to determine, in adults with type 1 diabetes, whether the glycaemic effects of high-intensity interval exercise (HIIE) vs moderate-...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵9/17) June 2026: From Dr. Paraskevas: “Pancreas Transplantation for Recipients with Type 2 Diabetes Mellitus: Results of an International Survey” PMID: 42256091 www.ovid.com/jnls/transpl...
ovid.com
Pancreas Transplantation for Recipients with Type... : Transplantation Direct
Background.Pancreas transplantation (PT), historically limited to patients with type 1 diabetes (T1D), is currently performed successfully in...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵8/17) June 2026: From Dr. Nostro: “Unravelling the developmental origins of cystic fibrosis-related diabetes” PMID: 42262528 link.springer.com/article/10.1...
link.springer.com
Unravelling the developmental origins of cystic fibrosis-related diabetes - Diabetologia
Cystic fibrosis (CF)-related diabetes (CFRD) is a growing and evolving concern for people living with cystic fibrosis. As its own unique clinical entity, there is an urgent need to better understand t...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵7/17) June 2026: From Drs P. MacDonald and Lynn: “Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation” www.biorxiv.org/content/10.6...
biorxiv.org
Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation
Stem-cell-derived β-like-cells (SCβ-cells) provide a promising platform for diabetes modelling and cell replacement therapy, but their incomplete functional maturation remains a challenge. Here, we co...
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵6/17) June 2026: From Drs. Verchere, Levings and Lynn: “Regenerative macrophages enhance stem cell-derived β cell function and engraftment” PMID: 42284401 www.science.org/doi/10.1126/...
science.org
Regenerative macrophages enhance stem cell–derived β cell function and engraftment
SC-β and SC-MReg coaggregates have improved insulin secretion, metabolic function, and reverse hyperglycemia in diabetic mice.
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵5/17) June 2026: From Dr. Kopp: “DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines” PMID: 42320878 www.sciencedirect.com/science/arti...
sciencedirect.com
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵4/17) June 2026: From Dr. Hoesli: “ Microscale strategies in engineering the pancreas: Toward clinical translation” PMID: 42303158 www.sciencedirect.com/science/arti...
sciencedirect.com
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵3/17) June 2026: From Dr. Gaisano: “Adipocyte caspase-8 but not RIPK3 promotes adiposity” PMID: 42337230 www.nature.com/articles/s41...
nature.com
Adipocyte caspase-8 but not RIPK3 promotes adiposity - Cell Death Discovery
Cell Death Discovery - Adipocyte caspase-8 but not RIPK3 promotes adiposity
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵2/17) June 2026: From Dr. Ferdaoussi: “Semaglutide-induced loss of skeletal muscle mass is blunted by co-administration of ketone esters” PMID: 42262870 insight.jci.org/articles/vie...
insight.jci.org
JCI Insight - Semaglutide-induced loss of skeletal muscle mass is blunted by co-administration of ketone esters
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CIRTN-R2FIC @cirtn.bsky.social · 08/09/2026
(🧵1/17) CIRTN labs continued to publish throughout the Summer. We will recap the works three parts. In June, there have been publications from Drs. Ferdaoussi, Gaisano, Hoesli, Kopp, Verchere, Levings, Lynn, P. MacDonald, Nostro, Paraskevas, Rabasa-Lhoret, Riddell, Rideout, Johnson and Rutter.
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵10/10) May 2026 CIRTN Labs' publications From Dr. Sefton: “Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases” PMID: 41965828 www.nature.com/articles/s43...
nature.com
Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases - Communications Medicine
Bakrania et al. reviews advances in RNA nanomedicine and regenerative medicine, outlining strategies for targeted RNA delivery and overcoming translational barriers. It identifies key challenges and p...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵9/10) May 2026 CIRTN Labs' publications From Dr. Screaton: “ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice” PMID: 41995846 link.springer.com/article/10.1...
link.springer.com
ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice - Diabetologia
Aims/hypothesis Reactive oxygen species modulator 1 (ROMO1) is a highly conserved inner mitochondrial membrane protein that senses reactive oxygen species and regulates mitochondrial dynamics. ROMO1 i...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵8/10) May 2026 CIRTN Labs' publications From Dr. Riddell: “Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic-hypoglycaemic glucose clamp..." PMID: 42168649 link.springer.com/article/10.1...
link.springer.com
Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic–hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes:...
Aims/hypothesis The aim of this study was to determine the effect of a novel somatostatin receptor 2 (SSTR2) antagonist, ZT-01, on impaired glucagon counterregulation in hypoglycaemia and its safety i...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵7/10) May 2026 CIRTN Labs' publications From Dr. Rabasa-Lhoret: “Barriers and Enablers to Diabetes Technologies Use Among Individuals With Type 1 Diabetes: A Scoping Review” PMID: 42086467 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
dom-pubs.pericles-prod.literatumonline.com
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵6/10) May 2026 CIRTN Labs' publications From Dr. Levings: “Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation” PMID: 42198842 www.cell.com/molecular-th...
cell.com
Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation
Engineered T cell therapies have transformed cancer treatment and similar principles are being applied in autoimmunity and transplantation. In this review Levings and colleagues discuss strategies to ...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵5/10) May 2026 CIRTN Labs' publications From Drs. Johnson and P. MacDonald: “From pancreas and islet resources to diabetes insights” PMID: 42065736 link.springer.com/article/10.1...
link.springer.com
From pancreas and islet resources to diabetes insights - Diabetologia
Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the de...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵4/10) May 2026 CIRTN Labs' publications From Dr. Hull-Meichle: “Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells” PMID: 42159696 link.springer.com/article/10.1...
link.springer.com
Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells - Diabetologia
Aims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵3/10) May 2026 CIRTN Labs' publications From Dr. Hill: “Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity... DALI randomised controlled trial” PMID: 42105870 www.diabetesresearchclinicalpractice.com/article/S016...
diabetesresearchclinicalpractice.com
Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled tria...
body mass index
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵2/10) May 2026 CIRTN Labs' publications From Drs Ferron and Rutter: “A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets” PMID: 42078397 www.medrxiv.org/content/10.6...
medrxiv.org
A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets
Aims and hypothesis Loss-of-function mutations in SLC30A8 , encoding the zinc ion (Zn2+) transporter ZnT8 in pancreatic beta cells, lower type 2 diabetes risk dose-dependently, but the underlying mech...
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CIRTN-R2FIC @cirtn.bsky.social · 05/06/2026
(🧵1/10) Here are publications that came out last month from CIRTN labs! Works are from the labs of Drs: Ferron, Rutter, Hill, Hull-Meichle, Johnson, P. MacDonald, Levings, Rabasa-Lhoret, Riddell, Screaton and Sefton.
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CIRTN-R2FIC @cirtn.bsky.social · 01/05/2026
(🧵22/22) CIRTN publications April 2026🌷 21) Dr. Bruce Verchere “Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists” PMID: 41906117 link.springer.com/article/10.1...
link.springer.com
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists - Genome Medicine
Genome Medicine - Type 2 diabetes (T2D) is a leading cause of morbidity and mortality worldwide. Despite the availability of multiple glucose-lowering agents, only half of individuals with T2D...
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CIRTN-R2FIC @cirtn.bsky.social · 01/05/2026
(🧵21/22) CIRTN publications April 2026🌷 20) Dr. Guy Rutter: “Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected ("hub"), and leader beta-cells” PMID: 42064760 www.frontiersin.org/journals/end...
frontiersin.org
Frontiers | Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected (“hub”), and leader beta-cells
Increases in cytoplasmic free Ca2+ ions ([Ca2+]) are a critical signal in pancreatic islet beta-cells and are usually required for insulin secretion in respo...
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CIRTN-R2FIC @cirtn.bsky.social · 01/05/2026
(🧵20/22) CIRTN publications April 2026🌷 19) Dr. Elizabeth Rideout: “Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females” PMID: 42039635 www.biorxiv.org/content/10.1...
biorxiv.org
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