iiinova — where your digital self keeps evolving

Reposted by Chris Hsu

Michael MacCoss @maccoss.bsky.social · 03/06/2026

Back to the Future! New preprint. A while back, we recognized that resonance excitation CID had real advantages over beam-type CID for data independent acquisition. The catch was speed: reCID was simply too slow to be practical. Not anymore. #proteomics #ASMS #DIA

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Reposted by Chris Hsu

Michael MacCoss @maccoss.bsky.social · 22/10/2025

Excited to see this published in JPR. For years I've wanted a simple way to standardize the signal between instruments. We use the precision of an intraspectrum ratio to assess the relationship between the reported signal and the number of ions. pubs.acs.org/doi/10.1021/...

pubs.acs.org

Evaluation of a Prototype Orbitrap Astral Zoom Mass Spectrometer for Quantitative Proteomics─Beyond Identification Lists

Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...

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Reposted by Chris Hsu

Michael MacCoss @maccoss.bsky.social · 01/06/2025

New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social! www.biorxiv.org/content/10.1...

biorxiv.org

Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists

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