Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polymers remains largely unexplored. Glycosylated nucle...

Recent studies have demonstrated that stereopure oligonucleotide phosphorothioates (PS), with defined configuration, provide significant advantages over stereorandom mixtures in therapeutic oligonucle...

Alternative methods for the preparation of naïve libraries for SELEX experiments are in dire need, particularly when hydrophobic, bulky, and complex modification patterns are considered. Here, we exp...

Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes which often result in improved binding properties. Most functional groups invo...

Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...

Institut Pasteur, ParisAuditorium François JacobMarch 4, 2025 PROGRAM 13:30 OPENING 13:40 Suzanne PEYROTTES (IBMM, Montpellier) “Discovery of an AcycloNucleoside Phosphonate (ANP) as potent inhibitor ...

Access to synthetic oligonucleotides is crucial for applications in diagnostics, therapeutics, synthetic biology, and nanotechnology. Traditional solid phase synthesis is limited by sequence length a...

The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...