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CHASERR Dad (Brian Broadbent)

@chaserrdad.bsky.social

Father of child with first neurological disease caused by a lncRNA (now published in NEJM). Hunting for a cure. Non-coding disease advocate. Based in Dallas, TX.

Posts Replies Media

Reposted by CHASERR Dad (Brian Broadbent)

Themis Tsarouchas @t-tsarouchas.bsky.social · 15/08/2025

Now out in Molecular Therapy! With Francesca Vacante, we describe MYRACL, a novel candidate lncRNA driving human oligodendroglia differentiation & myelination. Grateful to our amazing co-authors & mentors @annawilliamslab.bsky.social & Andrew Baker! Read more👇 www.sciencedirect.com/science/arti...

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Reposted by CHASERR Dad (Brian Broadbent)

Igor Ulitsky @igorulitsky.bsky.social · 29/05/2025

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 biorxiv.org/content/earl...

biorxiv.org

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

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