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Cell Regeneration @cell-regeneration.bsky.social · 31/08/2026

Cell Regen Research | A simplified dual-compound cocktail (phenylephrine hydrochloride + harmine) promotes heart regeneration by inducing an embryonic-like cardiomyocyte state!🫀 #HeartRegeneration #StemCells 🔗Check it out: doi.org/10.1186/s136...

Working model illustrating the sequential mechanism by which phenylephrine hydrochloride (PE) and harmine (HM) promote cardiomyocyte cell-cycle progression

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Cell Regeneration @cell-regeneration.bsky.social · 24/08/2026

Cell Regen Research | Wnt signaling drives reprogramming of human cells into presomitic mesoderm! A core transcription factor axis (CDX2–Brachyury–TBX6) creates a positive feedback loop that maintains this state. #StemCells #Reprogramming 🔗Full article at: doi.org/10.1186/s136...

Fig. 5e+k: CDX2 is required for human somitoid morphogenesis.

Left: HES7-GFP fluorescence images of somitoids derived from CDX2-knockout versus wild-type urinal derived presomatic mesoderm (UiPSM) clones over time.

Right: Regulatory network model showing how CDX2, T (Brachyury), TBX6, and Wnt/β-catenin form a positive feedback loop that maintains UiPSM identity.

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Cell Regeneration @cell-regeneration.bsky.social · 17/08/2026

Cell Regen Research | BayesPrism-DWLS enables integrated inference of cell-type proportions and gene expression from bulk RNA-seq and spatial data! #StemCells #Transcriptomics 🔗 Reveal cell-type-specific programs missed by conventional analysis: doi.org/10.1186/s136...

Schematic illustration of the benchmarking workflow and the BayesPrism-DWLS framework. Public scRNA-seq and bulk RNA-seq datasets from multiple tissues were used to systematically benchmark cell-type proportion and gene expression deconvolution methods. Performance was evaluated using Pearson correlation, RMSE, cosine similarity, and Bray–Curtis dissimilarity, together with additional experimental validation. Based on these results, the BayesPrism-DWLS framework was developed to infer cell-type proportions and cell-type-specific gene expression from bulk RNA-seq and spatial transcriptomics data. Figure created with BioRender.com

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Cell Regeneration @cell-regeneration.bsky.social · 11/08/2026

Cell Regen Research | CSRP3 drives satellite cell-mediated muscle regeneration in pigs (but not mice)! It regulates the AKT-SERCA2 pathway to control calcium homeostasis, mitochondrial function, and MYOG stability. #StemCells #MuscleRegeneration 🔗 Full article at: doi.org/10.1186/s136...

Role of the CSRP3-AKT-SERCA2 pathway in porcine and mouse skeletal muscle regeneration

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Cell Regeneration @cell-regeneration.bsky.social · 29/07/2026

Cell Regen Review | Signaling pathways regulating cardiac regeneration 🫀 Hippo/YAP, Wnt/β-catenin, NRG1-ErbB, MAPK, and Notch orchestrate cardiomyocyte proliferation and repair. #HeartRegeneration #StemCells 🔗 Full review at: doi.org/10.1186/s136...

Overview of signaling pathways regulating cardiomyocyte proliferation

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Cell Regeneration @cell-regeneration.bsky.social · 15/07/2026

Cell Regen Methodology | Orthogonal programming generates synthetic vascular organoids from hPSCs! #StemCells #VascularOrganoids 🔗 Follow the steps: doi.org/10.1186/s136...

Timeline for generation and application of synthetic vascular organoids from hPSCs

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Cell Regeneration @cell-regeneration.bsky.social · 08/07/2026

Cell Regen Review | Pro-regenerative drugs for muscular dystrophy: progress and challenges🦵 Enhancing endogenous muscle repair via MuSC activation offers hope beyond gene therapy. #MuscleRegeneration #StemCells 🔗 Full review at: doi.org/10.1186/s136...

Modality and concept of pro-regenerative drugs

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Cell Regeneration @cell-regeneration.bsky.social · 01/07/2026

Cell Regen Letter | Chemically induced pluripotent stem cells from umbilical cord MSCs! Improved small-molecule protocol achieves high-efficiency reprogramming with robust pluripotency and normal karyotype. #StemCells #iPSCs 🔗 Full letter at: doi.org/10.1186/s136...

Immunofluorescence of pluripotency markers in chemically induced pluripotent stem cells (CiPSCs) from umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs). Scale bar, 100 μm

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Cell Regeneration @cell-regeneration.bsky.social · 03/06/2026

Cell Regen Review |👃Olfactory epithelium regeneration and homeostasis: HBCs and GBCs drive lifelong neurogenesis through Wnt, Notch, and YAP signaling. New advances in organoids and spatial omics offer fresh insights! #StemCells #OlfactoryRegeneration 🔗 Full paper at: doi.org/10.1186/s136...

Epitheliopoiesis in the olfactory epithelium during homeostasis

Epitheliopoiesis in the olfactory epithelium post-injury regeneration

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Cell Regeneration @cell-regeneration.bsky.social · 19/05/2026

Cell Regen Report | Tollip antagonizes ESCRT-III-mediated plasma membrane repair, thereby regulating cell recovery and inflammatory signaling after membrane damage. #MembraneRepair #CellDeath 🔗 Full paper at: doi.org/10.1186/s136...

Tollip inhibits ESCRT-III recruitment to the plasma-membrane following damage and promotes plasma-membrane-integrity (PMI) signaling

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Cell Regeneration @cell-regeneration.bsky.social · 11/05/2026

Cell Regen Review | Advances in the application of human amniotic membrane for tissue repair🩹: In orthopaedics, obstetrics & gynaecology, and dermatology—from tendon repair and osteoarthritis relief to burn wound healing and more! #StemCells #TissueEngineering 🔗 doi.org/10.1186/s136...

Applications of processed amniotic membrane

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Cell Regeneration @cell-regeneration.bsky.social · 09/05/2026

Cell Regen Review | Cellular senescence: friend or foe in skeletal muscle regeneration? 💪Transient senescence in niche cells aids repair, but persistent senescence impairs it—especially in aging. #MuscleRegeneration #StemCells 🔗 Full paper at: doi.org/10.1186/s136...

Function of senescent cells in skeletal muscle regeneration

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Cell Regeneration @cell-regeneration.bsky.social · 07/05/2026

Cell Regen Research | MSI1 stabilizes Fthl17c mRNA to support TET-mediated DNA demethylation via bioavailable iron — forming a circuit that couples metabolism and epigenetics in mouse ESC pluripotency. #StemCells #Pluripotency 🔗 See the mechanism: doi.org/10.1186/s136...

MSI1-FTHL17C-Fe2⁺-TET regulatory axis that maintains DNA hypomethylation and ESC pluripotency

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Cell Regeneration @cell-regeneration.bsky.social · 28/04/2026

📨Cell Regen Meeting Report | Recent advances in TGF-β signaling: from regulation to clinical translation! Insights into Smad & non-Smad pathways, embryonic development, stem cells, and disease treatment. #TGFbeta #StemCells 🔗 Full paper at: doi.org/10.1186/s136...

DOI: https://doi.org/10.1186/s13619-026-00286-w

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Cell Regeneration @cell-regeneration.bsky.social · 02/03/2026

Cell Regen Research | Lysine crotonylation delays adipose-derived mesenchymal stem cell senescence & boosts efficacy in IBD! NaCr restores Kcr, suppresses NF-κB, and enhances anti-inflammatory effects in colitis models. #StemCells #InflammatoryBowelDisease 🔗 Full paper at: doi.org/10.1186/s136...

Schematic diagram of the ACSS2-H3K9cr axis in delaying senescence and improving the function of Adipose-derived mesenchymal stem cells (ADSCs)

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Cell Regeneration @cell-regeneration.bsky.social · 27/02/2026

Cell Regen Research | Embryonic intestinal Lgr5⁺ cells prior to villification (PVLCs) actively shape small intestinal morphogenesis before villi form via Hedgehog signaling! #Cellfate #IntestinalDevelopment 🔗 Full paper at: doi.org/10.1186/s136...

Embryonic intestinal Lgr5⁺ cells regulate small intestinal morphogenesis via Hedgehog signaling prior to vilification

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Cell Regeneration @cell-regeneration.bsky.social · 09/02/2026

Cell Regen Research | Frizzled-related protein (FRZB) protects periodontal ligament stem cells from inflammation-induced osteogenic defects!🦷 While inflammation downregulates FRZB and impairs osteogenesis, overexpression restores. #Periodontitis #StemCells 🔗https://doi.org/10.1186/s13619-026-00283-z

Frizzled-related Protein modulates mitochondrial function via the Wnt/β-catenin signaling pathway

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Cell Regeneration @cell-regeneration.bsky.social · 30/01/2026

Cell Regen Research | Even spaceflight-like aging reveals MRG15 as a key player 🧩 in muscle stem cell regeneration! Its decline in aged/injured MuSCs impairs regeneration via MyoD disruption & histone changes. #MuscleRegeneration #StemCells 🔗 Full paper at: doi.org/10.1186/s136...

MORF4-related gene on chromosome 15 (MRG15) interacts with MyoD to regulate histone acetylation and transcription of myogenic genes

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Cell Regeneration @cell-regeneration.bsky.social · 28/01/2026

Cell Regen Research | Speed up muscle repair! 🩹 Neonatal muscle extracellular vesicles activate satellite cells, boost regeneration, and reduce fibrosis/fat infiltration in glycerol injury models. #MuscleRegeneration #StemCells 🔗 Full paper at: doi.org/10.1186/s136...

Extracellular vesicles derived from neonatal mouse skeletal muscle accelerate muscle regeneration and reduce adipocyte infiltration and collagen deposition in vivo

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Cell Regeneration @cell-regeneration.bsky.social · 26/01/2026

Cell Regen Research | A new mouse model for precise endothelial cell ablation! 🩸Dual Cre/Dre logic activates DTR for precise vascular studies. #EndothelialCells #GeneEditing 🔗 Full paper at: doi.org/10.1186/s136...

DTR-mediated endothelial cell ablation after DT administration. A) Immunostaining for GFP, DTR, and DAPI on liver, heart, and lung sections from Cdh5-DTRGFP mice. B) A schematic showing experimental design. One pulse of PBS/DT was injected at 6 weeks, and mice were sacrificed after 2 days. C) Survival of DT treatment- and ctrl-mice. D) Bright field of the liver from DT-induced and ctrl mice. E) Immunostaining for GFP on livers from PBS- and DT-treated mice. F) Immunostaining for GFP, VE-cad, Ter119, and DAPI on liver, heart, and lung sections from mice treated with PBS or DT shows a significant leakiness of blood cells (arrowheads) in DT-treated mice. G) Analysis of the Ter119+ erythrocytes in liver, heart, and lung sections per 20×field from different sections. H) Schematic model of DTR-mediated endothelial cell ablation and vascular leakage. Upon binding to its DT, the DTR expressed on endothelial cells triggers specific cell death pathways. This resultant endothelial cell loss disrupts the integrity of the vascular wall, leading to vessel rupture and subsequent extravasation of erythrocytes.
Data are means ± SEM. n = 5 mice. The yellow scale bar represents 2000 μm. The white scale bar represents 100 μm.

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Cell Regeneration @cell-regeneration.bsky.social · 23/01/2026

Cell Regen Research | LncRNA-IH drives cardiac fibrosis after myocardial infarction!🫀🫀 Overexpression worsens remodeling & activates TGF-β1/ZEB1 in fibroblasts. #CardiacFibrosis #HeartFailure 🔗 Full paper at: doi.org/10.1186/s136...

Long non-coding RNA nonnmmut065573 (tentatively designated LncRNA-IH) activates the TGFβ−1 signaling pathway after myocardial infarction

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Cell Regeneration @cell-regeneration.bsky.social · 21/01/2026

Cell Regen Research | |✨Primed hPSCs → functional trophoblast stem cells in days?🧬 Transient MEK/ERK inhibition + balanced WNT yields stable hTSCs with strong STB/EVT potential. #StemCells #Trophoblast 🔗 Full paper at: doi.org/10.1186/s136...

DOI: https://doi.org/10.1186/s13619-025-00261-x

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Cell Regeneration @cell-regeneration.bsky.social · 19/01/2026

Cell Regen Research | CPP drives rapid endothelial differentiation of umbilical cord MSCs! 🧬🧬🧬 >90% VEC conversion in 5 days via MEG3 regulation—functional in vitro & in vivo. #StemCells #VascularRegeneration 🔗 Full paper at: doi.org/10.1186/s136...

Take-home figure: CPP drives the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into functionally competent vascular endothelial cells (VECs). Crucially, the long non-coding RNA MEG3 acts as a pivotal regulator within this differentiation pathway.

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Cell Regeneration @cell-regeneration.bsky.social · 16/01/2026

Cell Regen Report | Mammalian MSCs enhance zebrafish fin regeneration! 🐠🐠 MSC-derived PGE2 regulates macrophage recruitment & resolution, boosting repair. #Regeneration #Macrophages #StemCells 🔗 Full paper at: doi.org/10.1186/s136...

Exogenous murine MSCs enhance zebrafish fin regeneration

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Cell Regeneration @cell-regeneration.bsky.social · 22/12/2025

Cell Regen Research | α-Ketoglutarate boosts skin flap survival! 🩹 Enhances angiogenesis via PI3K/Akt/HIF-1α in ischemic flaps. #Angiogenesis #WoundHealing 🔗 Full paper at: doi.org/10.1186/s136...

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Cell Regeneration @cell-regeneration.bsky.social · 17/12/2025

Cell Regen Review | Imaging + single-cell omics: a new paradigm in developmental biology! 🔬Super-resolution & light-sheet meet spatial transcriptomics for multi-scale insights. #DevelopmentalBiology #SingleCellOmics 🔗 Full paper at: doi.org/10.1186/s136...

Integrating imaging technologies with single-cell & spatial omics – a new paradigm for developmental biology

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Cell Regeneration @cell-regeneration.bsky.social · 15/12/2025

Cell Regen Research | 🎯Direct Oct4 targets in ESCs revealed! Auxin-inducible degron (AID) system + nascent RNA-seq uncovers immediate transcriptional changes in pluripotency genes & non-coding RNAs. #StemCells #Pluripotency 🔗 Full paper at: doi.org/10.1186/s136...

Identification of direct OCT4 targets through integration of OCT4 ChIP-seq and nascent RNA-seq data

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Cell Regeneration @cell-regeneration.bsky.social · 10/12/2025

Cell Regen Report | Major step forward in 🦷 regeneration! New N2B27-based culture medium keeps mouse dental mesenchymal cells odontogenic for 14 days — BMP4 down, OPN/ATRA — enabling regenerative teeth in vivo. #ToothRegeneration #mesenchymalcells 🔗 Full paper at: doi.org/10.1186/s136...

The proposed mechanism for maintaining the odontogenic potential in dental mesenchymal cells (DMCs) using the novel N2B27-based culture medium

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Cell Regeneration @cell-regeneration.bsky.social · 04/12/2025

Cell Regen Research | 🔎Single-cell atlas reveals lifelong evolution of bone marrow vascular niche! From fetal liver to aged BM, Midkine emerges as a new regulator of HSPC reconstitution. #Hematopoiesis #StemCellNiche 🔗 Full paper at: doi.org/10.1186/s136...

A single-cell journey through the bone marrow vascular niche across life – meet the new player, Midkine!

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Cell Regeneration @cell-regeneration.bsky.social · 02/12/2025

Cell Regen Review | Poly(A) tails: the hidden switch in stem cell fate & early development! Length dynamics drive mRNA stability & translation. #StemCells #RNAbiology 🔗 Full review at: doi.org/10.1186/s136...

Regulation of Poly(A)-tails in stem cell and early development

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Cell Regeneration @cell-regeneration.bsky.social · 27/11/2025

Cell Regen Review | 📝Hypoxic–ischemic preconditioning (H/IPC) protects the 🧠 via mitochondrial metabolism—H/IPC boosts mitophagy, curbs fission & apoptosis for neuroprotection. #Mitochondria #Neuroprotection 🔗 More at: doi.org/10.1186/s136...

Hypoxic–ischemic preconditioning regulates mitochondrial metabolism

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Cell Regeneration @cell-regeneration.bsky.social · 24/11/2025

Cell Regen Research | Posterior enhancer (p-Enh) maintains neuromesodermal progenitor bi-potency during gastrulation! Deletion biases fate toward presomitic mesoderm, thereby disrupting spinal cord development. #StemCells #Embryogenesis 🔗 More at: doi.org/10.1186/s136...

p-Enh deletion disrupts NMPs’ bi-potency and biases lineage commitment toward PSM fate across in vitro, in vivo, and in silico models

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Cell Regeneration @cell-regeneration.bsky.social · 17/10/2025

Cell Regen Report | Validating quality standards for primary human hepatocytes! ✅ Tested viability, markers & metabolism in hepatocytes, revealing heterogeneity for liver studies. #Hepatocytes #CellBiology 🔗 More at: doi.org/10.1186/s136...

Single cell transcriptomic analysis on six primary human hepatocytes

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Cell Regeneration @cell-regeneration.bsky.social · 28/09/2025

Cell Regen Review | Rewiring cardiomyocyte identity & metabolism for heart regeneration! 🫀 Strategies for improving cardiac function in animal models. #HeartRegeneration #StemCells 🔗 More at: doi.org/10.1186/s136...

Schematic overview of cardiomyocyte regulators orchestrating the dedifferentiation, proliferation, and redifferentiation process

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Cell Regeneration @cell-regeneration.bsky.social · 08/09/2025

Cell Regen Review | Cell Regen Review | Drug-induced beta cell regeneration for diabetes! 🩺 Small molecules & pathways target proliferation to restore insulin production. #Diabetes #StemCells 🔗 More at: doi.org/10.1186/s136...

DOI: https://doi.org/10.1186/s13619-025-00255-9

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Cell Regeneration @cell-regeneration.bsky.social · 05/09/2025

Cell Regen Review | What tech is advancing central nervous system repair in neural regeneration? 🧠Optogenetics, gene editing, 3D culture, single-cell sequencing, 3D imaging and more… #NeuralRegeneration #StemCells 🔗More at: doi.org/10.1186/s136...

3D imaging of neural tissues using advanced tissue clearing and Light-sheet microscopy

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Cell Regeneration @cell-regeneration.bsky.social · 04/09/2025

✨Cell Regen Highlight | Transgene-free mouse embryo models via chemical reprogramming reach early organogenesis! Advances in PSC-derived iEFC-EMs & TF-SEMs for development & regen med. #StemCells #EmbryoModels More at: doi.org/10.1186/s136...

DOI: https://doi.org/10.1186/s13619-025-00259-5

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Cell Regeneration @cell-regeneration.bsky.social · 15/08/2025

Cell Regen Research | CD44 & Nucleolin regulate gliogenesis after spinal cord injury! scRNA-seq reveals SPP1-CD44 in microglia inflammation & PTN-NCL in astrocyte proliferation. #Inflammation #Gliogenesis 🔗More at: doi.org/10.1186/s136...

Microglial subpopulation subdivision and functional analysis showing CD44 as a key receptor regulating the inflammatory response

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Cell Regeneration @cell-regeneration.bsky.social · 13/08/2025

Cell Regen Review | FGSCs: Hope for ovarian repair & fertility preservation! 🧬 Recent advances in stem cells for aging/damaged ovaries, with challenges ahead. #StemCells #Fertility 🔗 doi.org/10.1186/s136...

Pathways for FGSCs to restore ovarian function (Modified from Servier Medical Art)

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Cell Regeneration @cell-regeneration.bsky.social · 04/08/2025

Cell Regen Review | Insights into tooth regeneration! 🦷 Stem cells & scaffolds drive pulp-dentin trials, while enamel repair evolves. #ToothRegeneration #StemCells 🔗Read more: doi.org/10.1186/s136...

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Cell Regeneration @cell-regeneration.bsky.social · 15/07/2025

Cell Regen Research | 10-species microbial signature for IBD diagnosis. 🩺 XGBoost model (XGB-IBD10) achieves 87% accuracy!🎯 #IBD #Microbiome 🔗 doi.org/10.1186/s136...

XGB-IBD10 achieves a better performance than other top species-based methods

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Cell Regeneration @cell-regeneration.bsky.social · 07/07/2025

Cell Regen Research | MANF-modified Schwann cells (SC) boost peripheral nerve repair! 🧠 Enhances axon regeneration & SC dynamics. ✨ #NerveRegeneration #SchwannCells 🔗 doi.org/10.1186/s136...

Schwann cells expressing Dox-inducible MANF protect axons and promote regeneration

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Cell Regeneration @cell-regeneration.bsky.social · 03/07/2025

Cell Regen Research | Got a gut feeling? HIFT boosts microbiota diversity & Faecalibacterium for better gut health!💪 #GutMicrobiota #GutHealth #Exercise 📖https://doi.org/10.1186/s13619-025-00244-y

Characteristics of microbial alpha-diversity and beta-diversity among MICT, HIIT and HIFT

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Cell Regeneration @cell-regeneration.bsky.social · 23/06/2025

Cell Regen Letter | YTHDF2-KIF26B-Wnt loop drives intestinal stem cell stemness! m6A reader YTHDF2 regulates Wnt signaling, with compensatory mechanisms revealed👇. 📖 doi.org/10.1186/s136... #StemCells #GutHealth

A positive-feedback loop formed by YTHDF2-KIF26B-Wnt signaling maintains the stemness of ISCs

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Cell Regeneration @cell-regeneration.bsky.social · 18/06/2025

🎊Latest on Cell Regeneration! We maintain our strong position in Clarivate #JCR2025: IF=4.7! 🔬 Q2 in Cell & Tissue Engineering (Top 31%) 🧫 Q2 in Cell Biology (Top 34%) Grateful to our authors, reviewers & readers! #ImpactFactor #ScienceMetrics #Stemcells 🔗 cellregeneration.springeropen.com

cellregeneration.springeropen.com

Cell Regeneration

Cell Regeneration is officially affiliated with the Chinese Society for Cell Biology (CSCB). It aims to become an international academic platform for the ...

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Cell Regeneration @cell-regeneration.bsky.social · 06/06/2025

Cell Regen Research | Mongolian medicine Eerdun-Wurile boosts heart regeneration in zebrafish! 🫀 Enhances cardiomyocyte proliferation via MVDA, offering myocardial infarction therapy insights. #Cardiology #Regeneration 🔗 doi.org/10.1186/s136...

Eerdun-Wurile effectively restores heart function in zebrafish Representative heartbeat fluctuations charts of zebrafish in control

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Cell Regeneration @cell-regeneration.bsky.social · 05/06/2025

Cell Regen Research | ⚙️Deep learning measures single-cell stiffness! High-throughput, non-invasive models predict MSC & macrophage mechanics, advancing mechanobiology. #DeepLearning #Biomechanics 🔗 Full study at: cellregeneration.springeropen.com/articles/10....

Schematic representation for the image-based cell stiffness evaluation using deep learning

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Cell Regeneration @cell-regeneration.bsky.social · 04/06/2025

Cell Regen Review | New review explores alternative splicing’s role in stem cell fate & development! Splicing factors & emerging tech like CRISPR shape the future. #StemCells #Differentiation 📖Full study: cellregeneration.springeropen.com/articles/10....

Emerging technologies in alternative splicing research

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Cell Regeneration @cell-regeneration.bsky.social · 29/05/2025

Cell Regen Research | Unlocking stem cell potential! Inhibiting METTL3 boosts naïve pluripotency via m6A-YTHDF2-Gstp1, enhancing reprogramming. #StemCells #Epigenetics 📖Full study: cellregeneration.springeropen.com/articles/10....

Schematic diagram of the regulatory mechanism of METTL3-m6A-YTHDF2 axis in PNT

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Cell Regeneration @cell-regeneration.bsky.social · 22/05/2025

Cell Regen Research | New study reveals BMP signaling’s critical role in gastric epithelial cell differentiation via organoids! Decoding niche factors for gastric homeostasis. #StemCells #CellDifferentiation

Differentiation paths of gastric epithelial cells and signaling regulation

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