iiinova — where your digital self keeps evolving

Reposted by Celine Fox

Claire Gillan @clairegillan.bsky.social · 01/08/2024

Interested in the structure of psychopathology? We have a new preprint for you osf.io/preprints/ps... led by @celinef.bsky.social "Mechanistic arbitration between candidate dimensions of psychopathology"

osf.io

OSF

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Celine Fox @celinef.bsky.social · 27/11/2023

9/10 A massive thanks to my fantastic co-authors and collaborators, including @kellydonegan.bsky.social 🌟, especially the #Neureka team who gathered all of this wonderful data, our funders and my supervisor @clairegillan.bsky.social 🙏

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Celine Fox @celinef.bsky.social · 27/11/2023

8/10 Meta Mind exemplifies how to adapt established cognitive tasks for within-person, longitudinal assessments, facilitating the development and testing of causal models 🔄.

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Celine Fox @celinef.bsky.social · 27/11/2023

7/10 The high reliability observed may suggest that hybrid ‘self-report-cognition’ 🤝 tasks may be overall more reliable than behaviour-only assessments and thus be one way to bridge the reliability gap in computational psychiatry 🌉.

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Celine Fox @celinef.bsky.social · 27/11/2023

6/10 Metacognitive biases in decision-making are highly stable within-session, exhibit strong reliability 💪 and associations with clinical correlates are evident in as few as 40 trials, facilitating the rapid 🏃‍♀️ detection of individual differences in metacognition

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Celine Fox @celinef.bsky.social · 27/11/2023

5/10 We additionally observed high test-retest reliability with Meta Mind and replicated previously established associations with psychiatric dimensions 📈 in our very large sample of citizen scientists 🧑‍🔬

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Celine Fox @celinef.bsky.social · 27/11/2023

4/10 Relative to the traditional task, we demonstrated the convergent validity and excellent split-half reliability of metacognitive bias in Meta Mind ✅. In contrast, metacognitive efficient was neither valid nor reliable ❎ with Meta Mind (likely due to low trial N < 100).

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Celine Fox @celinef.bsky.social · 27/11/2023

3/10 To achieve this, we developed Meta Mind 🧠, a gamified smartphone task 🤳 designed to measure metacognitive (confidence) bias and investigated its psychometric properties against a traditional metacognitive task

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Celine Fox @celinef.bsky.social · 27/11/2023

2/10 While metacognitive disturbances have been reported across various aspects of mental health 🙇‍♀️, most research has been cross-sectional. The next frontier is a shift towards repeated assessments of metacognition in individuals over time ⏰, through treatment 💊, and in real world environments 🌍

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Celine Fox @celinef.bsky.social · 27/11/2023

📢 Delighted to share the second preprint of my PhD work! 🎉 Across 2️⃣ experiments (N=3410 unpaid citizen scientists, N=52 paid participants), we developed a new smartphone game 📱👾 to measure metacognition 🧠 reliably, rapidly and remotely over time osf.io/preprints/ps... … 1/10

osf.io

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Reposted by Celine Fox

Claire Gillan @clairegillan.bsky.social · 22/11/2023

We are recruiting a new PhD student to work on an exciting new area in our lab - developing passive smartphone 📱proxies for cognition and symptoms with lots of cool data science methods and a clinical focus on psychotic like experiences in the gen. pop. gillanlab.com/join-the-lab/

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Celine Fox @celinef.bsky.social · 22/11/2023

9/9 Lastly, a massive thanks to my other fantastic co-authors and collaborators, especially the PIP study team who gathered all of this wonderful data 🌟 and my supervisor @clairegillan.bsky.social, and our funders 🙏

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Celine Fox @celinef.bsky.social · 22/11/2023

8/9 This is important because it suggests that negative biases in anxious-depression are not fixed or final, they can change through time or through treatment.

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Celine Fox @celinef.bsky.social · 22/11/2023

7/9 Though these samples are too small for individual difference estimates, we note a general pattern across all arms, where changes in confidence over time track changes in anxious-depression. We think this suggests metacognitive biases in anxious-depression are state-dependent.

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Celine Fox @celinef.bsky.social · 22/11/2023

6/9 Among patients starting antidepressant medication 💊 (N=82) and a control group receiving no intervention 🙅‍♂️ (N=88), we found a significant increase in confidence in the antidepressant arm, but not among controls. Caveat, the interaction is p=0.06 🙃.

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Celine Fox @celinef.bsky.social · 22/11/2023

5/9 Turning to changes over time – anxious-depression significantly reduced after 4 weeks of iCBT 📉, and this was accompanied by an increase in confidence 📈. Importantly, those with the greatest reductions in anxious-depression levels had the largest increase in confidence.

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Celine Fox @celinef.bsky.social · 22/11/2023

4/9 Prior to receiving iCBT, ‘anxious-depression’ was associated with under-confidence, while ‘compulsive and intrusive thoughts’ was associated with over-confidence in performance, replicating 🔄 previous work and extending it to a new sample - treatment seeking patients.

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Celine Fox @celinef.bsky.social · 22/11/2023

3/9 They signed up online and completed a metacognitive task and self-report questionnaires at baseline and 4-week follow-up, without ever meeting us 🧑‍💻

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Celine Fox @celinef.bsky.social · 22/11/2023

2/9 We collected these data as part of the PIP study, introduced by @ctlee.bsky.social. Participants initiating iCBT from SilverCloud via an NHS site or an Irish mental charity Aware, were invited to take part in our study. More on that here ⬇️ bmcpsychiatry.biomedcentral.com/articles/10....

bmcpsychiatry.biomedcentral.com

The Precision in Psychiatry (PIP) study: Testing an internet-based methodology for accelerating rese...

Background Evidence-based treatments for depression exist but not all patients benefit from them. Efforts to develop predictive models that can assist clinicians in allocating treatments are ongoing, ...

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Celine Fox @celinef.bsky.social · 22/11/2023

🚨 🗞️ Excited to share our new study is now published in eLife! @elife.bsky.social We tested the state-dependence of metacognition 🧠 among N=649 before and after 4 weeks of iCBT 🧑‍💻, along with a smaller antidepressant arm 💊 and a control group.. elifesciences.org/articles/87193 …a 🧵 1/9

elifesciences.org

An observational treatment study of metacognition in anxious-depression

Improvement in levels of anxious-depression corresponds with increased confidence in performance among individuals receiving mental health treatment within a large longitudinal dataset.

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Celine Fox @celinef.bsky.social · 22/11/2023

Thanks Micah! Glad you enjoyed, looking forward to chatting with you when you visit us in the new year!

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