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Celia Ferriol-González @celiaferriolg.bsky.social · 03/06/2026

On Monday June 1, I finally defended my PhD thesis entitled "Genetic determinants and implications of host range in Klebsiella phages". Thank you to my supervisor @pilardomingoc.bsky.social, and my team for these years filled with a lot of learning and great moments.

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Reposted by Celia Ferriol-González

PLOS Biology @plosbiology.org · 28/11/2025

Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY

Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).

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Reposted by Celia Ferriol-González

Pilar Domingo-Calap @pilardomingoc.bsky.social · 28/11/2025

Very proud of @celiaferriolg.bsky.social! Amazing experimental evolution for phage optimization and for host range expansion, allowing us to understand the evolvability of phage RBPs. This work is part of her PhD project at the #EnBivirLab @i2sysbio.es @uv.es @ccbiologiquesuv.bsky.social

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Reposted by Celia Ferriol-González

PLOS Biology @plosbiology.org · 28/11/2025

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