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Misconceptions and Set-Points
For decades, the concept of a thermoregulatory "set-point" has been a cornerstone of physiological research, yet its definition and application remain surprisingly inconsistent across disciplines. Our recent study, spear-headed by the inimitable Dr. Duncan Mitchell, soon to be published in Biological Reviews, revisits and clarifies this fundamental concept by bridging perspectives from control theory and thermal biology. We explore how the set-point framework has been misinterpreted, and we argue for a more precise definition rooted in negative feedback principles.