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Manhart Lab

@carolmanhart.bsky.social

278 followers 126 following 2 posts

Studying DNA Repair at Temple University

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Manhart Lab @carolmanhart.bsky.social · 14/03/2025

Congratulations to third year graduate students Yasmine Sakinejad and Amruta Bhalkar on successfully elevating to Ph.D. candidacy! Woohoo!!

Manhart Lab @carolmanhart.bsky.social · 17/01/2025

Check out the preprint of our latest work: www.biorxiv.org/content/10.1...

The mismatch repair factor Mlh1-Pms1 uses ATP to compact and remodel DNA

In eukaryotes, mismatch repair begins with MutS homolog (MSH) complexes, which scan newly replicated DNA for mismatches. Upon mismatch detection, MSH complexes recruit the PCNA- stimulated endonucleas...