Thrilled to share this new publication from my colleague Joseph Giorgio. Great article on how sex and genes may influence the buildup of harmful proteins in the brain linked to AD and why some people may be better candidates for new therapies than others. #dementia
www.nature.com/articles/s41...
nature.com
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions - Nature Communications
In Alzheimer’s disease cohorts with whole genome sequencing and tau and amyloid-β, the authors show that sex, APOE-ε4 and TREM2 impact tau via both Aβ and tau pathways. APOE-ε4 homozygotes and TREM2 c...
