iiinova — where your digital self keeps evolving

Ane Appelt @cancerphysicist.bsky.social · 26/07/2025

That would be amazing! Tuesday morning works - just let me know when fits you 😊

Ane Appelt @cancerphysicist.bsky.social · 25/07/2025

AAPM, here I come! Only my 2nd time ever, and 7 years since I last went 😳 Have acquired a few more grey hair & wrinkles in the meantime, but still excited to hear what’s happening on the other side of the pond. And please all reach out if you want to meet up! #medphys #AAPM2025

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Ane Appelt @cancerphysicist.bsky.social · 11/07/2025

Biked the 7km home in the rain in high heels and a dress. I believe this means I’m now formally reassimilated? 🇩🇰 🚴‍♀️ #Copenhagen #CyclingCulture

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Ane Appelt @cancerphysicist.bsky.social · 02/07/2025

My inaugural lecture as Professor of Clinical Medical Physics at Rigshospitalet and DTU will be on the 6th Oct at 3pm in Auditorium 1, Rigshospitalet, Copenhagen It would be lovely to see a lot of familiar faces, for the lecture and for the reception afterwards ☺️ #medphys #radonc

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Ane Appelt @cancerphysicist.bsky.social · 20/06/2025

Survived the first week in my new workplace. Got an office, computer, keys & ID card - and so many lovely and welcoming colleagues. Key items have been added to my empty office shelves, and I’ve got tentative plans for stuff to work on over the coming months. Could do with some sleep, though 😂

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Ane Appelt @cancerphysicist.bsky.social · 15/06/2025

Apparently blocks of perspex do indeed show up as water equivalent on airport security scanners. Lesson learned, I guess 🤷🏻‍♀️ #medphys

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Reposted by Ane Appelt

Gjert Moldestad @gjertm.bsky.social · 28/05/2025

For noen kan et lite regnbueflagg bety at vi føler oss tryggere. Man ser flagget og tenker; « her kan jeg passe inn» En enkel måte å vite at jeg også blir satt pris på. Veldig fin video Oslo Pride🌈

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

It was a pleasure! Thank you so much for keeping me company 😊 Hope the last leg is at least going smoothly - LNER did their job and got me onto another train, so now heading north to Leeds

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

😂 😂 We had enough of an ESTRO contingent on the train that we could have reasonably brought her with us 😁 (Although … you were nominally the industry representative in the group. So wasn’t the coffee your responsibility?!?)

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

Well, we’ve got as far as Brussels. Now waiting for the 14:52 Eurostar (after the staff kindly rebooked us). So only 2 hours delay so far, at least - but I’m really sad about missing out on a leisurely morning with breakfast on the train 🙁

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

Oh well, that didn’t quite go to plan … Got 9 hours of restful sleep and a shower, but now stuck in Cologne waiting for a replacement bus. At least I’ve got good company! #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

In terms of the response rate, I think that’s actually pretty good, given that it’s 6 months later and many of these patients were referred back to surgical departments etc, so lost contact with the RT department. And we didn’t use electronic questionnaires, so they had to get it in person

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Ane Appelt @cancerphysicist.bsky.social · 07/05/2025

Good questions, and maybe @beardy-econ.bsky.social is better placed to answer 😊 But no, they weren’t all treated identically - most were included in the APHRODITE trial, which ment that they were randomised between standard and dose escalated LCRT. But some were treated outside trial

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

My feet are shattered by too much walking in heels, and I'm functioning on about 15 hours of sleep over the last five days. So now hanging out in a cool little cafe, trying to keep awake before boarding the night train to Brussels🚆 See you all in Stockholm next year #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

This was also my very first conference with my partner attending - and we even had a joint study to present 😊 bsky.app/profile/canc...

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

I gave a total of 5 talks, attended & chaired numerous meetings, made it to too few of the scientific talks (🙏 online recordings!), and saw so many friends and colleagues that I have lost count a long time ago. I even managed to meet a few new people (@NiuSanford!) #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

I got to catch up with my partner in crime (i.e. all things #reirradiation) Eliana Vasquez Osorio, who gave a brilliant - as always - talk on image registration for reRT dose accumulation today #radonc #medphys #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

We got to present our innovative #reirradiation treatment planning solution, developed in close collaboration with RaySearch - and we saw the near-final implementation in RayStation. I can't believe that this may soon be available for clinical treatments! bsky.app/profile/canc...

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

#ESTRO25 was dominated by #reirradiation for me: invited talks, collaborators w/ presentations, Physics ReRT Working Group meeting, launch of the multidisciplinary ESTRO ReRT Focus Group, lunchtime meet&greet, rectal cancer reRT guidelines & more bsky.app/profile/canc...

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

The lower GI clinical trials sessions were packed with groundbreaking findings: primary reporting from STAR-TREC, PLATO ACT 4, PRIME-RT, STELLAR II, CAO/ARO/AIO-16, and more bsky.app/profile/canc... No other scientific meeting has this high level of #radonc trial & research!

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

What a blast - #ESTRO25 has been absolutely amazing 🙌 The scientific programme was outstanding: not only the clinical track - with many, many large trials reported - but also extremely strong #medphys, #RTT and #radbio tracks

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

I couldn't agree more. We need more patient involvement - and we need it to not be confined to the last Tuesday session! I couldn't make it (speaking at the same time ...), but it looks like it was an excellent session - can't wait to catch up on the recording #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

Interesting perspective on #ESTRO25 from a #healthecon researcher. Where is all the research on decision making, patient preferences, valuation - and, to some extend, QoL and PROMs?

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Ane Appelt @cancerphysicist.bsky.social · 06/05/2025

Love it when a plan comes together! This year’s joint #ESTRO25-AAPM symposium is the culmination of 3 years of cross-Atlantic #reirradiation collaboration🤩 🔹Chuck Mayo: #medphys-led workflows 🔹Søren Bentzen: #radbio 🔹Marija Popovic: dose accumulation 🔹Lone Hoffmann: reRT trial design & QA

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Dose metrics linked to bowel toxicity for rectal RT in the RAPIDO trial: Amazing work by Max Tanaka from NKI Medium-to-high dose volumes for bowel bag (RTOG or Embrace) best predictors for both acute & late toxicity - V30Gy for LCRT, V20Gy for short course #ESTRO25 #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Hella Sand looked at rigid v deformable reg for lung #reirradiation. Both performed well, with good inter-centre consistency, but less variation for DIR, especially for cumulative max dose. Results have driven recommendations in the CURE Lung reRT trial #radonc #medphys #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Isak Wahlsted led a national study of dose accumulation for #reirradiation: 8 diverse cases evaluated in all Danish RT centres Image reg was consistent & high quality; but differences in a/b & tissue recovery gave substantial intercentre variation in cumulative dose #medphys #radonc #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Inter-centre variation in image registration for #reirradiation from DK: Two great studies from collaborators presented at #ESTRO25 Conclusions: Image registration-based dose accum for reRT is feasible. For lung, DIR is better than RIR. Radiobio factors largest source of variation #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Great to see first outputs from ESTRO-EORTC ReCare cohort on high-dose #reirradiation - such data are sorely needed! Jonas Willmann presented characteristics for first 290 patients #ESTRO25; w/ large groups of thoracic & pelvic cancers. Current patient enrolment closing in on 500 patients! #radonc

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

What a way to celebrate a paper! Arnaud Beddok had arranged for chocolate and champagne for the whole co-author group to mark the acceptance of a large review paper for publication. Way to set the bar high for future papers 😅 #ESTRO25 #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 05/05/2025

Oh - that might need to be my next coffee break …

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Amazing Reirradiation Meet&Greet session at #ESTRO25 today! Fantastic turnout, and great opportunity to present how much we’ve already done on #reirradiation within ESTRO Now really looking forward to working with all the new members of the Reirradiation Focus group #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Well, I’ve managed one coffee … @bostonscientific.bsky.social has almost no queue, and good (and surprisingly strong!) coffee ☕️ #ESTRO25 #coffeechallenge

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

This has honestly been an issue for me … 😰

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Slightly delayed, but a summary of the key reirradiation sessions and presentation at today's #ESTRO25 In particular, note the dedicated #RTT and #brachytherapy reirradiation sessions 😍 #radonc #medphys #reirradiation

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

I’m SO delighted to finally see first STAR-TREC data reported 🤩 #ESTRO25 Short course RT vs chemorad for organ preservation in early stage rectal cancer 61% vs 80% TME-free survival at 12 months ➡️ More organ preservation with long-course chemorad! #radonc #rectalcancer

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Excellent to also see the quality of life data, demonstrating the positive patient impact of RT dose reduction #radonc #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

PLATO ACT 4 results for dose de-escalation in early-stage anal cancer are out! Prof Sebag-Montefiore presents on the plenary stage at #ESTRO24 3-year locoregional failure 16.4% for standard dose IMRT vs 12.4% reduced dose IMRT Primary endpoint is met! Reduced dose IMRT is safe & effective #radonc

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Today, I need to try out some of the many recommendations in the replies to the previous message #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 04/05/2025

Yesterday was terrible for my coffee sampling! Far too busy meeting people, and only managed a single coffee from the GE stand. At least it was a delightful reunion with both their barista and their excellent coffee (and the queue was short!). #ESTRO25 #CoffeeChallenge

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

Things that make me happy: Seeing an RT planning & evaluation solution for #reirradiation that I’ve helped develop in its (nearly) final version. Amazing work by @raysearchlabs.bsky.social @solstina.bsky.social @crukradnetleeds.bsky.social & colleagues. Probably highlight of #ESTRO25 so far for me 😍

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

Key findings 🔹Patients on average required 0.34pp higher chance of cure to accept 1pp higher chance of short-term side effects 🔹Patients required 0.78pp higher chance of cure to accept 1pp higher chance of long-term side effects 🔹Shift towards higher preference for NOM post-treatment

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

96 patients completed a discrete choice experiment (DCE) pre-treatment and 6 months post-treatment (n=62) in seven UK RT centres #ESTRO25 #radonc #rectalcancer

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

How do patients prioritise different aspects of non-operative rectal cancer treatment? We conducted a prospective, longitudinal multicentre study alongside a clinical trial, asking rectal cancer patients undergoing definitive RT to help us understand their treatment preferences #ESTRO25 #RadOnc

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

I’ve been far too busy with meetings 😳 So no coffees sampled yet 🫣 (I know, I know, I’m really letting the side down …) Everybody else, please tell me what should be my first break stop in the exhibition hall??? #ESTRO25

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

Why? Not quite clear, but Prof Offersen speculates that the effective dose might simply be too low with 40Gy/15# for this group. (They’ve carefully confirmed that it’s not a question of RT quality!) #ESTRO25 #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

Important (and puzzling) results from the Skagen Trial 1: Moderate hypofractionation for high-risk (node-positive) breast cancer patients does not increase arm lymphoedema - but is *does* seem to increase the breast-cancer related mortality 😲 #ESTRO25 #radonc

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

Here are some of the (many) other presentations on #reirradiation today at #ESTRO25 🤩 #radonc #medphys

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Ane Appelt @cancerphysicist.bsky.social · 03/05/2025

For even more #reirradiation highlights and discussion, join the dedicated conference WhatsApp group! #ESTRO25 #medphys #radonc

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