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CAMEO-3D

@cameo3d.org

www.cameo3d.org CAMEO (Continuous Automated Model EvalutatiOn) is a community project to continuously evaluate the accuracy and reliability of 3D complex structure predictions. Developed by @sib.swiss and @biozentrum.unibas.ch.

Posts Replies Media

CAMEO-3D @cameo3d.org · 08/08/2025

Runs N' Poses is a great example of how to rigorously filter protein–ligand complexes for structural similarity: www.biorxiv.org/content/10.1....

Figure 4 in the Runs N' Poses paper shows how one can combine sequence identity with ligand similarity metrics to assess the structural novelty of protein-ligand complexes.

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CAMEO-3D @cameo3d.org · 08/08/2025

Filtering out homologous structures from the PDB at 40% sequence identity is not enough to create a robust test set. Significant leakage persists at this level, and comparative modeling can still produce high quality models.

Scatter plot of LDDT as a function of sequence identity for high coverage homology models. The horizontal red line at 40% sequence identity highlights the presence high quality models in the low sequence identity region.

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CAMEO-3D @cameo3d.org · 28/04/2025

Create your account and register your server now! cameo3d.org

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CAMEO-3D @cameo3d.org · 28/04/2025

Detailed per-target scores and interactive 3D visualization.

The target page with server results and superposed 3D structures.

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CAMEO-3D @cameo3d.org · 28/04/2025

Custom timeframes, automatic server comparisons on shared targets, multi-metric evaluations, and interactive boxplots for selected servers.

The CAMEO results page with custom timeframes, common subset comparison, and boxplots

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CAMEO-3D @cameo3d.org · 28/04/2025

Introducing CAMEO Structures & Complexes - automated weekly blind benchmarking of structure prediction servers. Now with heteromeric and protein-ligand complexes. Join us and register your server now! cameo3d.org

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