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CalcinottoLab

@calcinottolab.bsky.social
103 followers 112 following 7 posts

We pioneer next-generation immunotherapy by blocking pro-tumoral immune activity. Our research uncovers how tumor cells, microbiota, and immune infiltrates drive hormone-dependent and BRCA-mutated cancers. ior.usi.ch/group/cancer-immunothera…

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Reposted by CalcinottoLab
Institute of Oncology Research (IOR) @iorbellinzona.bsky.social · 19/08/2025
#IORnews The Cancer Immunotherapy lab, led by Prof. A. Calcinotto, uncover a new immune–tumor interaction in ER+ breast cancer, opening the way for targeted therapies. 🔗Read more: ior.usi.ch/events-news/... @calcinottolab.bsky.social
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CalcinottoLab @calcinottolab.bsky.social · 31/07/2025
🚀 Excited to share our latest publication! 👉 www.nature.com/articles/s41... A fantastic collaboration with an incredible team. #BreastCancer #Neutrophils #TumorMicroenvironment #PARPinhibitors #DNARepair #NatureCommunications #CancerImmunology #CalcinottoLab
nature.com
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition - Nature Communications
Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologou...
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CalcinottoLab @calcinottolab.bsky.social · 17/06/2025
Join us for the session “DNA Repair and Immunosurveillance” at #EACR2025, where I’ll be giving a talk on neutrophils and synthetic lethality in breast cancer”
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CalcinottoLab @calcinottolab.bsky.social · 08/05/2025
Senescent neutrophils: a hidden role in cancer progression: Trends in Cell Biology www.cell.com/trends/cell-...
cell.com
Senescent neutrophils: a hidden role in cancer progression
Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body o...
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CalcinottoLab @calcinottolab.bsky.social · 27/04/2025
Getting ready to start! Join us for this session #AACR2025 where I will be speaking alongside Nicky McGranahan and Ronny Drapkin. Looking forward to an exciting discussion on how immunology shapes cancer initiation! 1:00 p.m. - 2:30 p.m. — see you there!
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CalcinottoLab @calcinottolab.bsky.social · 21/04/2025
Thrilled to share that our group will be presenting at a major symposium at the AACR Annual Meeting in Chicago this Sunday! Catch us at AACR—Chicago, we’re ready! #AACR25 #CancerResearch #Immunology #SomaticEvolution #EarlyDetection #CancerBiology #TeamScience #SeeYouInChicago
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CalcinottoLab @calcinottolab.bsky.social · 16/04/2025
Bellinzona is ready to host the next SYIS seminar on April 17! I’m excited to join the event as a speaker, alongside Christian Pasquali from OM Pharma. Join us at 5:00 pm (CET) — either in person in Bellinzona or online via Zoom!
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CalcinottoLab @calcinottolab.bsky.social · 15/04/2025
Thrilled to share our new review published by @cp-trendscellbio.bsky.social In this article, my lab explores the heterogeneity of cancer neutrophils and discusses their implications in both cancer progression and therapy resistance. Check out the full review here: pubmed.ncbi.nlm.nih.gov/39362804/
pubmed.ncbi.nlm.nih.gov
Senescent neutrophils: a hidden role in cancer progression - PubMed
Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body o...
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