Developed at the Brazilian Center for Research in Energy and Materials, this technology enables the three-dimensional cultivation of cells and allows for a more accurate assessment of the toxicity of ...

Chronic stress from people’s everyday lives may be causing lasting structural changes to the heart, harming health and reducing life expectancy.

A materials scientist in a pediatric cancer lab at Hollings Cancer Center is merging her interests to create new models for sarcoma.

Researchers found that tiny particles in the blood may keep nerves irritated after the shingles virus is gone, causing pain to continue.

Children who have been in contact with dogs in early childhood are on average healthier and require fewer antibiotic courses than children without such contact.

The first publicly-funded randomised controlled trial in the UK has found that a single dose of psilocybin, the active compound found in 'magic mushrooms', produced significant improvements in depres...

Researchers found HSV-1 rewires energy metabolism in human neurons, with early metabolic activation followed by oxidative stress and mitochondrial changes.

Lab‑grown ‘mini‑inner ears’ shed new light on hearing loss

Researchers mapped 13,609 proteins across healthy, fetal, and cancer tissues using mass spectrometry. The atlas revealed developmental links between tumors and embryonic tissues.

Surrey and Roehampton researchers found gut bacteria linked to key brain chemicals GABA and glutamate in a new human study. Discover more.

Even for the same brain tumor treated with the same anticancer drug, the effect can differ from patient to patient.

A study from the landmark RxPONDER clinical trial shows that ovarian reserve is a better predictor of chemotherapy benefit than age or menopausal status.

Scientists’ ability to recapitulate the human brain in a dish has always been hindered by the inability to model the full capacity of the brain and its development through time. | Scientists’ ability ...

Cancer’s deadliest move is often not the growth of the original tumor, but its ability to travel. Metastasis, the spread of malignant cells from a primary site to distant organs, is responsible for a

Broad scientists expand the DepMap by adding cancer organoids and demonstrate the models’ potential to fuel new discoveries.

The largest genetic study of fibromyalgia has identified 26 risk-associated genomic regions, with many linked to neural functions. The findings support fibromyalgia as a nervous system disorder and hi...

Generative AI gives health experts ability to create realistic synthetic genetic data to identify behaviour of disease complications.

Using patient-derived brain cells, imaging, and AI, researchers screened 63 approved medicines for Sanfilippo syndrome. Nine improved cellular health, supporting drug repurposing as a potential strate...

People with both atrial fibrillation and Alzheimer’s disease who are treated with modern NOAC blood-thinning medicines may experience a slower rate of cognitive decline. This is shown by a study from ...

Tissue chips developed by researchers from the University of Rochester’s Translational Center for Barrier Microphysiological Systems (TraCe-bMPS) were accepted into the FDA’...

Researchers tested psilocybin-assisted therapy in 12 veterans with treatment-resistant PTSD. Nine patients achieved remission with no serious adverse events, supporting larger controlled trials.

As microbiome research moves beyond cataloging which microbes are present, organ-on-a-chip technologies are helping scientists observe how cells, microbes, immune signals, and physical forces interact...

New projects to move UK science away from animal testing

Vivodyne's AI experiments on lab-grown human tissue could soon replace the need to test drugs on mice or dogs—and the approach has the potential to create drugs that work better.

Researchers analyzed glioblastoma samples and identified TRNAU1AP as a key driver of cancer stem cell survival. They identified the IGF2BP3- TRNAU1AP pathway as a potential therapeutic target.

Researchers have developed a large biobank of tumor organoids. The biobank is expected to enable scientists to identify the genes that specific cancers depend on for growth, revealing potential weak p...

Researchers have developed an AI test that predicts breast cancer recurrence risk using standard pathology slides and clinical data. The approach matched or outperformed genomic testing, offering fast...

PLN cardiomyopathy increases the lifetime risk of sudden cardiac death. Researchers analyzed disease mechanisms using patient and stem cell models. They found that RNA therapy has the potential to nor...

New study reveals that exceptional memory aging cannot be explained simply by low inherited Alzheimer's disease risk, reinforcing the importance of studying protective pathways directly.

Researchers identified a 19-protein blood signature that can predict when ALS symptoms are likely to develop, often years before onset.

Consumption of ultra-processed food (UPF) results in a distinct metabolic ‘signature’ in the blood, associated with potentially adverse health conditions, a new study by an international team of resea...

The proposal would allow OHSU researchers to continue doing some experiments using primates, while charting a path to breeding fewer monkeys and investing more in alternatives.

Miniature brain models grown from patients’ cells revealed striking differences in how Alzheimer’s-related tissue responds to an antidepressant. The organoids and the particles they release could…

Bioengineers have developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells. This open-access resource could help researchers…

New UBC research could expand genetic screening for families at risk of aggressive cancer.

By Mara Johnson-Groh, freelance science writer for American Institute of Physics Publishing’s Scilights, and Kelly Hermans, University of Utah Scientific Computing and Imaging Institute A version of t...

A surprising discovery is reshaping scientists' understanding of how humans develop sharp central vision before birth. Instead of blue cone cells migrating away from the retina's center, the...

The brain’s waste clearance system is impaired in people living with ME/CFS which can lead to various symptoms including brain fog.

Future therapies for respiratory syncytial virus (RSV) must target both the virus and its immune response to ensure babies get the best possible outcomes, finds a new study by researchers at UCL and G...