Exploiting #biocatalysis for the synthesis of densely functionalised heterocycles.
Excited to see this work from my time in the Flitsch lab out now in #JACS.
Thanks to co-first author Lea, Grayson, Pere Clapés and Sabine Flitsch!
#ChemSky #ChemBio @uommib.bsky.social @acs.org
pubs.acs.org
Stereoselective Chemoenzymatic Cascades for the Synthesis of Densely Functionalized Iminosugars
1,4-Dicarbonyls are versatile synthons for the construction of diverse pharmacophores and natural products. However, the stereoselective synthesis of densely functionalized 1,4-dicarbonyls is challeng...