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Brynja Sigurpálsdóttir

@brynjad.bsky.social

Research scientist at deCODE genetics, working on methylation data from long-read sequencing and racing triathlons in my freetime🧬 Interested in long-read sequencing, DNA methylation, machine learning, big data

Posts Replies Media

Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

Many thanks to all the co-authors! @bvhalldorsson.bsky.social

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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

This work highlights how long-read sequencing opens a new window into the epigenetics of aging, not just by measuring methylation genome-wide but resolving how aging affects the two parental haplotypes differently. (5/5)

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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

4. Example of progressive erosion of parent-of-origin specific methylation with age at DIRAS3 locus (4/5)

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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

3. Most importantly, long-read sequencing allowed us to phase methylation to maternal and paternal haplotypes, revealing parent-of-origin specifici age-associated methylation changes at imprinted loci that cannot be detected with conventional approaches. (3/5)

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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

Our study shows that: 1. More than 20% of measured CpGs change with age and its mostly decreasing with age 2. Highly accurate methylation clocks can be developed using long-read sequencing data (2/5)

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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026

Excited to share our new paper in Nature Communications! rdcu.be/fwOV9 We used @nanoporetech.com to sequence 7,284 individuals and measured DNA methylation at ~18 million high-quality CpG units across the genome (1/5)

rdcu.be

Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome

Nature Communications - DNA methylation changes with age, but parent-of-origin effects remain poorly characterised. Here, the authors use nanopore sequencing to map age-associated methylation...

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