iiinova — where your digital self keeps evolving

Thiago Bruder @bruder-thiago.bsky.social · 03/02/2025

What's surprising? Unlike small vessels, PGRN deficiency reduces vascular contractility in large vessels (aorta). Why? We're still exploring! 🤔 Previously, we showed that a lack of PGRN increases vascular response in resistance artery. www.ahajournals.org/doi/10.1161/...

ahajournals.org

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation | Journal of the American Heart Association

100