Great to learn about the amazing phage defence lit (thanks @ellinoralseth.bsky.social!), def want this to be a positive contrib– many more Qs to ask from evol perspective. Hopefully a useful framework to think about other puzzling phenotypes in microbiology authors.elsevier.com/a/1nllx,L%7E...
![A workflow for evaluating defense mechanisms in an evolutionary context: Starting from an initial discovery of a defense mechanism [typically bioinformatic (2) or experimental (3)], we emphasize the importance of explicitly identifying alternative defense and nondefense evolutionary hypotheses (1) and using these hypotheses to drive additional experimental and bioinformatic tests. Arrows highlight iterative integration (4): bioinformatic discoveries (2) can drive experimental predictions (3) by inspiring new testable hypotheses (1). Similarly, experimental data (3) can drive bioinformatic predictions (2), a process mediated by new functional hypotheses (1). Mechanisms can cycle through these steps multiple times as new data accumulate, both within and across multiple studies (4).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:w6ipl5c32bene36ros2fqv3m/bafkreicua5c5bzjws7kmxqdewuqghobz3czcmpv43um5qym3tozo44n5re)
