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Brittney Murray @brittmurray.bsky.social · 07/01/2025

It's finally here! The #DSP exercise data you've all been waiting on! TLDR: different appearance than in PKP2 #ACM, but intense exercise not good in DSP ACM either. #cardiogen www.heartrhythmjournal.com/article/S154...

heartrhythmjournal.com

Endurance Exercise Promotes Episodes of Myocardial Injury in Individuals with a Pathogenic Desmoplakin (DSP) Variant

Desmoplakin (DSP) variants are associated with left-predominant or biventricular arrhythmogenic cardiomyopathy. Exercise promotes penetrance and sustained ventricular arrhythmias (VA) in right-sided arrhythmogenic right ventricular cardiomyopathy, but its effect is unknown in DSP variant carriers.

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