🧬 #InsideBrigantLab | CRISPR
CRISPR is a family of systems with different functions. Here, we focus on 🎯 Cas9, which targets DNA, and Cas13, which targets RNA.
DNA or RNA targeting opens different possibilities for understanding and engineering diseases.
#CRISPR #ScienceSky #AcademicSky
![🚨 Exciting Research Update! 🚨
We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉
We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬
Why is this important?
These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡
A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨
🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio]
📖 Stay tuned for more updates from BrigantLab ! 🚀
#ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:uswgysbcxwxhseeof5gcws4m/bafkreieti3s22avgebtftt3nmezne2ag7q4xb4jlvpznsqkt4kvkohyzju)
