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Brennan Lab CVR

@brennanlab.bsky.social
94 followers 62 following 14 posts

Lab Account | PI: @bbrennan83 | 🔬 bunyavirus/vector interactions at @CVRinfo.bsky.social🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧🇱🇹🇲🇦🇹🇭🇪🇺🏳️‍⚧️🏳️‍🌈

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Brennan Lab CVR @brennanlab.bsky.social · 25/09/2026
@alainkohlvirology.bsky.social
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Brennan Lab CVR @brennanlab.bsky.social · 25/09/2026
📣 Excited to share our latest PLOS Pathogens paper We developed a reverse genetics system for Bhanja virus and show that lineage-specific NSs proteins differentially antagonise interferon, affecting viral fitness. 🎉 🔗 doi.org/10.1371/jour... #Virology #PLOSPathogens
doi.org
Functional divergence of the Bhanja virus NSs protein modulates interferon antagonism and viral fitness across divergent lineages
Author summary Bhanja virus is a tick-borne virus distributed across Asia, Africa, and Europe that causes neurological disease, yet little is known about how it replicates or evades immunity. We devel...
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Brennan Lab CVR @brennanlab.bsky.social · 12/05/2026
📝 Conserved pathogenesis of ancestral & contemporary Oropouche virus in a murine pregnancy model (led by Natasha Tilston) — out in Nature Comms 🦟 #Oropouche www.nature.com/articles/s41...
nature.com
Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model - Nature Communications
Oropouche virus (OROV) is an emerging virus in Latin America. Here the authors show in a mouse model that OROV infects the placenta and can reach the fetus during pregnancy, a conserved feature across...
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Brennan Lab CVR @brennanlab.bsky.social · 12/05/2026
📝 SFTSV NSs protein is a novel tick antiviral RNAi suppressor — out now in PNAS 🧵#SFTSV www.pnas.org/doi/10.1073/...
pnas.org
SFTSV NSs protein is a tick antiviral RNAi response suppressor | PNAS
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the nonstru...
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Brennan Lab CVR @brennanlab.bsky.social · 12/05/2026
Not often you get to say two papers dropped the same day 😱🎉🥳🍾 Incredibly proud of both — great science, amazing collaborators, and a lot of hard work 💪 #Virology #Bunyavirus #EmergingViruses
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Brennan Lab CVR @brennanlab.bsky.social · 18/09/2025
Not for want of trying tho! Haha
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Brennan Lab CVR @brennanlab.bsky.social · 18/09/2025
Happy to chat, drop me an email: Ben.brennan@glasgow.ac.uk :)
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Reposted by Brennan Lab CVR
Fletcher Lab @fletcherlab.bsky.social · 08/09/2025
Pre-print: our description of RZ affiliate ZNFX1 is now online. On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution. Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX...
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Reposted by Brennan Lab CVR
Marine Petit @virotick.bsky.social · 19/08/2025
Curious about tick virology? Read my latest piece in @uk.theconversation.com where I explain findings of my latest research article www.nature.com/articles/s41... Hope it will helps people to understand the importance of studying tick and their pathogens #ScienceforAll #WomenInScience #Arbovirose
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Brennan Lab CVR @brennanlab.bsky.social · 15/08/2025
📢 Thrilled to share our NEW PREPRINT! SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠 🧫 NSs essential for tick but not mammalian infection 🧬 Binds 22-nt viral siRNAs to block RNAi 🕷️ Reveals host-specific viral immune evasion 📖 doi.org/p2vf #lovevirology #bunyavirus #tickborne
doi.org
SFTSV NSs protein is a novel tick antiviral RNAi response suppressor
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...
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Brennan Lab CVR @brennanlab.bsky.social · 13/08/2025
Post 5/5 🧵 IMPACT: This transforms tick-borne disease research: 🎯 New drug targets 🎯 Understanding vector competence 🎯 Virus-tick evolution Testing if mechanisms work across other tick viruses next. 👨‍🔬 collaborative project with @alf-castello.bsky.social and @alainkohlvirology.bsky.social
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Brennan Lab CVR @brennanlab.bsky.social · 13/08/2025
Post 4/5 🧵 SURPRISE: TOP3B knockdown had a weird effect: Viral RNA levels: unchanged Infectious particles: dramatically reduced Suggests TOP3B helps maintain viral RNA conformation for proper packaging. Tick & human versions remarkably similar! #lovevirology
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Brennan Lab CVR @brennanlab.bsky.social · 13/08/2025
Post 3/5 🧵 DISCOVERY: Virus systematically hijacks tick RNA machinery: 🔹 RNAi pathway: UP (tick defense) 🔹 Translation: UP (viral protein synthesis) 🔹 rRNA processing: DOWN (disrupts cell proteins) 18 proteins both changed activity AND bound viral nucleocapsid! #bunyavirus
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Brennan Lab CVR @brennanlab.bsky.social · 13/08/2025
Post 2/5 🧵 METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells. Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too! #RNABiology #collaboration #Scitech
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Brennan Lab CVR @brennanlab.bsky.social · 13/08/2025
Thread: How Viruses Hijack Tick RNA Machinery 🧬🕷️ Post 1/5 🧵 We just published the first map of how viruses rewire tick cell RNA machinery! Led by Alexandra Wilson & Wael Kamel! We Found 283 proteins that change RNA-binding during Uukuniemi virus infection. 📄 Our paper: doi.org/10.1371/jour...
doi.org
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
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Brennan Lab CVR @brennanlab.bsky.social · 12/07/2025
Lovely time celebrating Andrew’s PhD Graduation last week 🎓🎉🍾 #nextsteps #lovevirology #bunyavirus
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Reposted by Brennan Lab CVR
Nature Communications @natcomms.nature.com · 11/07/2025
Scientists uncover how ticks fight off and carry a virus deadly to humans @virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social @uniofsurrey.bsky.social #SFTSV
bit.ly
Scientists uncover how ticks fight off and carry a virus deadly to humans
The study, published in Nature Communications, provides the most detailed picture yet of how cells from the tick species Rhipicephalus microplus respond to infection with severe fever with thrombocytopenia syndrome virus (SFTSV).SFTSV can cause high fever, internal bleeding and death in humans and currently has no licensed treatment or vaccine.
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Reposted by Brennan Lab CVR
Marine Petit @virotick.bsky.social · 23/05/2025
Finally A BIG THANK YOU to all my co-authors, they made this long journey started in 2021 a bit smoother! Thanks to Scaturro lab, Kohl lab, @brennanlab.bsky.social, @quangu.bsky.social, and Dundee proteomics! And of course thanks to the Tick cell Biobank and Lesley for those tiny cells!
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Reposted by Brennan Lab CVR
Marine Petit @virotick.bsky.social · 23/05/2025
OMG! I can finally share my joy to see my SFTSV work published in @natcomms.nature.com! This adventure started by the award of my MSCA grant and my move to the Kohl and @brennanlab.bsky.social at @cvrinfo.bsky.social. Let's chat about how we discovered novel tick anti-viral effectors!
nature.com
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...
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