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Luca Braccioli Lab @ UU

@bracciolilab.bsky.social

144 followers 158 following 34 posts

Exploring the interplay between gene regulation and tissue-tissue interactions in stem cell-based embryo models.

Posts Replies Media

Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 24/06/2026

🧩 What is the role of translational regulation during early tissue development? I am very grateful to have been awarded the ECR Seed Grant to answer this question together with @thejoanasilva.bsky.social ! #UtrechtLifeSciences #EarlyCareerResearchers #Gastruloids

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 13/02/2026

🧬 We are excited to announce the INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026 — Engineering the Origins of Life 📅 7–8 May 2026 📍 Utrecht, The Netherlands Register & submit abstracts: www.oncodeinstitute.nl/internationa...

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

8/10 In conclusion, our work provides an innovative framework for dissecting the crosstalk between gene regulation and inter-tissue communication in mammalian embryonic development.

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

7/10 Finally, we used chimeric gastruloids derived from a mix of wild-type (WT) and MSGN1 KO cells. This revealed that MSGN1 KO cells can form spinal cord in the presence of WT cells. This indicates an underlying inter-tissue communication program driven by MSGN1.

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

6/10 Surprisingly, MSGN1 KO not only impaired mesoderm development, as anticipated, but also negatively affected spinal cord development. This reveals an inter-tissue role of MSGN1 that was previously unknown.

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

4/10 Next, we investigated which transcription factors (TFs) are active during gastruloid development. To do this, we defined the developmental trajectories in gastruloids and predicted TF activity based on their motif accessibility.

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

3/10 We discovered that the chromatin regulatory profile of gastruloids strikingly matches that of post-gastrulation embryos.

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Luca Braccioli Lab @ UU @bracciolilab.bsky.social · 18/03/2025

2/10 We utilized single-cell ATAC-seq to analyze developing mouse gastruloids, successfully defining their chromatin regulatory profile.

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