A beautiful collaboration with the Accardi and Robertson labs is out! Using a battery of structural/biophysical techniques, we show that CLC-ec1 undergoes large-scale, pH-dependent structural changes - we propose this underlies common gating. Read below!
www.nature.com/articles/s41...
nature.com
Structural basis of pH-dependent activation in a CLC transporter - Nature Structural & Molecular Bio...
This study reveals the mechanism by which protons gate a CLC-type Cl−/H+ exchanger. The authors show that pH-dependent concerted structural rearrangements open the H+ pathway, which allosterically e...
