Four humours in balance, the ancients decreed - so open a vein, let the bad blood be freed. From Galen to Harvey, from humours to genes,  From black bile and phlegm to the things on our screens. ...

Bloody Minded · Episode

Taunted by transferrin? Befuddled by ferritin? Scratching your head at why we throw the serum iron results directly into the confidential waste bin, which is a more dignified burial than it deserves? ...

One molecule to rule them all, one molecule to find them. One molecule to bring them all, and in the liver bind them. Hepcidin is the key to understanding iron metabolism and we examine how iron gets ...

Join us in our third straight week of incredibly nice and incredibly talented haematology gurus as Professor John Moore joins us as an expert guest to discuss stem cell transplant in the myeloid dis...

What happens when you take someone who is really really ridiculously good at haematology and also a really really ridiculously nice person as well? You get Dr Jad Othman , consultant Haematologist an...

“It’s pronounced nuc-ul-ophosmin” “Nucleophosmin”. “Noo-clee-o-phosmin”. FLT3-ITD got you In The Dumps? Have a Total Knowledge Deficit about TKD mutations? Struggling with the A-B-Cs of NPM1 mutations...

U-G-L-Y, you ain't got no alibi, you dysplastic yeah yeah you dysplastic. Apologies to all the ring sideroblasts out there, but this week the Bloody Minded crew is doing a Mean Girls and judging cells...

What do arsenic, acne tablets and Jodi Picoult have in common? Why, it must be a deep dive with Nick, Bashar and Cale on acute promyelocytic leukaemia. From buzzwords to brain bleeds, the sweetest of ...

Cat got your tongue? Or in this case - mucositis? Does converting the acute allogeneic transplant patient who can no longer eat's medications to IV fill you with dread? In this practical for once epis...

Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and...

What if the prequel had a prequel? Join Bashar, Nick and Cale as they attempt to unpack the newfangled world of clonal haematopoeisis. Find out how CHIPs can kill and no, it’s not due to eating too ma...

  If we’re going to truly understand myeloid disease, we must dispense with the ward and journey to the dystopian heart that beats at the centre of each dysplastic cell. Learn what is valid and i...

Happy marrows are all alike; every unhappy marrow is unhappy in its own way.  When haematopoiesis behaves itself, it’s frankly quite boring. When it goes rogue, it can get very creative. Join Cal...

What’s a CHIP and why is it so delicious? Why do we still abbreviate myeodysplastic neoplasm to MDS? How did Bashar get his hands on the Necronomicon? These are questions that every budding haematolog...

Hi-ho, Hi-ho, it's off the myeloid factory we go. Grab your fastest belt, a spare inserter and all the iron plates you can get your hands on as the Bloody Minded Crew embark on their nerdiest referenc...

Does my blood look fat in this? Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer t...

Does my blood look fat in this? Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer t...

Twas the night before Christmas, and all through the house, not a creature was stirring, particularly not a missing coagulation factor. Welcome to a very special present all wrapped and delivered by S...

We’ve had one difficult coagulation topic yes, but what about second difficult coagulation topic? We are joined by the fantastic Dr Caroline Dix today to take us through not one but TWO challenging ...

Sometimes something comes along that puts a chill down the spine of every doctor. Any conversation that starts with "Oh hey do you remember that patient you saw...?". Mystery meat day in the cafeteria...

Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent fil...

Lions and tigers and… thrombosis? Oh my! Join the Bloody Minded Crew on the yellow brick road to visit the emerald laboratory and see the wonderful wizard of clots - your friendly laboratory coagulati...

“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WO...

We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, ute...

It's said that beauty is skin deep but you know what else lurks just under your epithelium - CLOTS! Nick, Cale and Bashar head very slightly under our outer layer to the peripheral vasculature in this...

D-ismayed by D-readful D-ressing D-owns by your D-emonstrably D-eplorable registrar? . Join de Bloody Minded Crew for a Tour D-Force of D-Dimer D-rama as we D-issect and D-iscuss this most D-ifficult ...

Join the Bloody Minded Crew as they get to the heart… no get to the lungs of the topic of Pulmonary Embolism. VanQuish the V/Q and CriTically aPprAise the CTPA with these acronyms that are just as bad...

Calves, thighs, arms and more,  Clots can form inside them all! Join your hosts Cale, Bashar and Nick as they take a deep (hah) dive into the nitty-gritty things you should know about managing ...

Rudolf the red nosed physician Wrote a very cool triad And if you ever saw it you would even say ‘Egad!’ All of the other physicians used to laugh and call him dumb They never let poor Rudolf  j...

Philip K. Dick once wrote, “Perhaps if you know you are insane then you are not insane. Or you are becoming sane, finally. Waking up.” Waking up, that is, not to the alternative history universe where...

Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse?  Why does everyone f...

Red cells. White cells. Platelets. Plasma. Proteins. By your powers combined I am Captain… Whole Blood? Wouldn’t it be so much easier if we could work with each of these blood components individually....

FOUR Antibodies. THREE Animals. TWO Crying Haem Registrars. ONE TEST - The MAIPA. Actually maybe more than two crying haem registrars. How many antibodies are too many antibodies to have inside...

The mighty eosinophil had triumphed. The last parasitic worm lay vanquished beneath his granule-studded pseudopodia. For years, he’d battled helminthic scourge, a hero in mucus armor. But now, with no...

Put on your monocles and kimonos and hop on the monorail to our episode composed of monotonous monologues, monogamously dedicated to that most monolithic and sometimes monoclonal of mononucleated cell...

Behold the field in which I grow my cells and see that it is barren. It’s out of the frying pan and into the aplastic fire with not a cell in sight. Join Nick, Cale and Bashar without two neutrophils ...

Once again the Bloody Minded Crew have ventured out of the lab to find and trap another haematology registrar from the wards and convince them to come back to the show and talk about cells. Join haema...

Whilst most of haematology is spent looking forlornly into the empty neutrophil cupboard like old Mother Hubbard - post chemotherapy, the pendulum can also swing to the other extreme. Join us as we un...

A lone neutrophil stands alone against a horde of gram negative bacteria. He is the last of his kind, the single granulocyte rising from the ashes of a marrow once verdant with haematopoiesis, now ove...

There’s a problem with billionaires at the moment. Every day, you make a hundred billion platelets. For some in our society, even that colossal quantity isn’t nearly enough. They strive ever onward fo...

Are you a platelet that has been conjugated to an antibody? Sequestered in a spleen? Diluted out by too much saline? Had your precious gold stolen from you? Then you might be entitled to thrombensati...

Our half empty cup from last week has now runneth over! If having low red cells is a bad thing, then having an extremely high amount must be a good thing, right? WRONG! Join the Bloody Minded Crew&n...

All that blood study making you faint, fatigued and short of breath? Well, you might be anaemic but how can we tell why? Join us on our first trip of the season of highs and lows as we take apart th...