Can aging tissues “forget” how to repair - or is repair actively blocked?
Using a human stem-cell-derived RPE aging model, we show that repair competence persists in aged cells and can be reactivated by transient senolytic treatment. We term this “senolytic priming.”
www.biorxiv.org/content/10.6...
biorxiv.org
Senescence targeting re-enables injury-responsive repair in a human RPE aging model
Aging is associated with progressive tissue dysfunction and impaired repair after injury. In the retinal pigment epithelium (RPE), these changes contribute to age-related macular degeneration (AMD), y...
