The spatial resolution of optical imaging systems is fundamentally restricted by the diffraction limit. However, in widefield live-cell microscopy, the achievable resolution is further constrained by ...

Increasing evidence shows that myopia, a prevalent ocular disorder and the leading cause of visual impairment worldwide, is associated with significant alterations in the biomechanical properties of t...

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In our research, we combined optical tweezers to apply force on a cell with Fӧrster resonance energy transfer to measure the internal tension on vinculin, a protein involved in the focal adhesion of t...

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The dielectric environment and membrane dipole potential are key electrostatic properties of biological membranes, which modulate the function of membrane-associated proteins. If and how these propert...

The presented study aimed to investigate the antibacterial activity of menthol—the main component of one of the widespread plants of the Lamiaceae family—Mentha arvensis. To investigate the mode of…

α-Synuclein (αSyn) is an intrinsically disordered protein that preferentially binds anionic membranes with lipid packing defects. Cholesterol is an abundant membrane component that regulates packing…

Precise surface engineering is essential for robust characterization of extracellular vesicles and their interactions with biologically relevant interfaces. In this study, gold substrates were…

Capturing dynamic cellular processes in live cells requires fast imaging with very high resolution beyond the diffraction limit. Fluctuation-based super-resolution techniques overcome this limit by…

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In our research, we used primary hippocampal neurons to study how therapeutically significant compounds modulate mitochondria-mediated cell death during excitotoxic stress. The cover image of the…

Embryonically, the vertebrate brain begins as an approximately uniform, fluid-filled epithelial tube that undergoes rapid volumetric expansion and regionalization to form the morphologically distinct ...

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Neurons form functional connections in neuronal networks of the brain. Neurotransmission refers to the information flow of electrical signals between neurons, and changes in the information flow…

Escherichia coli swimming motility is powered by the flagellar motor, a rotary nanomachine driven by inward proton flux through its torque-generating stators. How these proton currents arise from…

Conduction velocity slows along axons, yet the right-skewed distribution of the terminal-to-initial velocity ratio ρ=vend/vstart has length-invariant mean and variance. A bounded multiplicative…

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In our research, we used primary hippocampal neurons to study how therapeutically significant compounds modulate mitochondria-mediated cell death during excitotoxic stress. The cover image of the…

Biophysical Reports will soon be implementing a new article type, Method Review. This article type is intended to offer researchers an opportunity to present an overview of an existing method of…

Schizophrenia is a multidimensional psychiatric disorder lacking a unifying systems-level framework. We introduce a cortical brain entropy architecture that characterizes the spatial and hierarchical…

The presented study aimed to investigate the antibacterial activity of menthol—the main component of one of the widespread plants of the Lamiaceae family—Mentha arvensis. To investigate the mode of…

The crystal structure of a chitooligosaccharide deacetylase (COD) from the marine bacterium Vibrio campbellii (formerly V. harveyi), referred to as VhCOD, exhibits a homodimeric assembly, consistent w...

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Transthyretin (TTR) amyloidosis is one of the most common forms of systemic amyloidosis, involving deposits of pathogenic TTR aggregates in tissues and organs throughout the body. TTR aggregation is i...

Our group focuses on the fundamental physics that enables the auditory system to detect extremely small, rapid mechanical movements. We study how it senses sub‑nanometer deflections, how it preserves…