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Michael J. Robertson

@biophysicsguy.bsky.social
847 followers 259 following 27 posts

Assistant Professor in Biochemistry & Molecular Pharmacology, Baylor College of Medicine. CryoEM, GPCRs, Membrane Proteins, Comp Chem, SBDD.

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Michael J. Robertson @biophysicsguy.bsky.social · 11/03/2026
Excited to share our work is out in @Nature ! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. www.nature.com/articles/s41...
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Michael J. Robertson @biophysicsguy.bsky.social · 27/01/2026
New preprint from the Robertson Lab! We used AF ensemble generation for rigidity filtering with generative design to make cryoEM fiducials, enabling rapid inactive states of four drug targets and a beta2 extracellular fiducial to study GPCR activation! www.biorxiv.org/content/10.6...
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Michael J. Robertson @biophysicsguy.bsky.social · 22/12/2025
Excited to share our study resolving the GTP-induced activation of the mu-opioid receptor-Gi complex with different agonists using cryoEM and MD simulations is live now @nature.com with additional MD sims, fluorescence work, and more! www.nature.com/articles/s41...
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Michael J. Robertson @biophysicsguy.bsky.social · 07/07/2025
Happy to share that our paper on Metric Ion Classification (MIC) is now published! www.nature.com/articles/s41...
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Michael J. Robertson @biophysicsguy.bsky.social · 02/06/2025
Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving the landscape of Gi activation and how its modulated by different ligands! www.biorxiv.org/content/10.1...
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Michael J. Robertson @biophysicsguy.bsky.social · 20/03/2024
Very excited to share our new preprint where we develop MIC, a deep metric learning tool for classifying waters & ions in experimental structures; fantastic collaboration with the extremely talented Laura Shub and Selina Liu from the Keiser lab! www.biorxiv.org/content/10.1...
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Michael J. Robertson @biophysicsguy.bsky.social · 31/01/2024
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Michael J. Robertson @biophysicsguy.bsky.social · 24/10/2023
I am delighted to announce I will be joining Baylor College of Medicine Biochemistry & Molecular Pharmacology as an Assistant Professor in January 2024! Huge thanks to CPRIT and NICHD for generous additional startup funding; I’ll be hiring at all levels soon!
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Michael J. Robertson @biophysicsguy.bsky.social · 19/10/2023
The new multicolor 3D printer is working great! GABAB with phospholipids and antagonist, SSTR2 with Nb6, and GFP with a glow in the dark fluorophore.
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