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Barbara Hernando

@bhernando.bsky.social

183 followers 356 following 29 posts

Postdoctoral Junior Leader at CNIO funded by LaCaixa | Cancer genomics, evolution & early detection | Heptathlete forever

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

14/ Extending to mCRPC (HMF, n=240) we emulated an RCT: IMF6-high patients had markedly lower risk of treatment failure on ARPIs vs taxanes (HR 0.21). Retrospective, n=25 vs 94, hypothesis-generating – but mechanistically coherent via SPOP.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

12/ Clinical: 4 IMFs (ROS, AR, non-canonical HR, canonical HR) carried HRs of 4–7 for metastasis vs non-CIN, independent of age, Gleason grade group, stage, TMB and late-to-early RT ratio. And they stratified WITHIN GG2/GG3 – the actual grey zone.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

10/ Topography mattered. SNVs and SVs are enriched at tumour-specific ARBS — and SBS1 is DEPLETED there. Why? AR binds unmethylated CpGs. We confirmed it directly with Nanopore methylation in 8 tumours.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

7/ Result: 8 integrated mutational footprints (IMFs). Important: these are NOT subtypes. Every tumour carries activities across several IMFs; what differs between patients is which processes are running and how strongly. A spectrum, not eight boxes.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

4/ Challenge 1: the SV description was too coarse for prostate cancer. Solution: extend it. We classified each rearrangement by class × size × replication timing × fragile site – and, new here, by whether it fell at an AR binding site (ARBS). 6 stable cSV signatures came out.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

2/ Motivation: signature analysis has been siloed by variant class. But one broken mechanism doesn't confine itself to one class — the same failing machinery that miscopies a base also duplicates a segment and shatters a chromosome. Read them separately, see four things.

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Barbara Hernando @bhernando.bsky.social · 04/12/2025

Had a lovely dinner today with members of @s-j-aitken.bsky.social’s lab to celebrate my recent preprint! Sharing these small milestones (and the joy that comes with them) with friends is just magic ✨

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Barbara Hernando @bhernando.bsky.social · 14/05/2025

Flying back from Bologna after the Pan Prostate Cancer Group #PPCG meeting. 3 days of fruitful discussions with lovely colleagues at the best venue I have ever been 🤩

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Barbara Hernando @bhernando.bsky.social · 26/04/2025

Ready for #AACR25! Excited for five full days of talks, posters and educational sessions in cancer research, and also for catching up with colleagues and friends 🤩

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