Neuropsychopharmacology - A transient mitochondrial switch underlies long lasting effects of adolescent cannabis

Neuroscience; Behavioral neuroscience; Systems neuroscience

Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimu...

Although obesogenic high-fat/high-sugar diets impair memory function in humans and rodents, the underlying mechanisms remain elusive. Given that the b…

Canela et al. introduce a data-driven pipeline to dissect second-order conditioning (SOC) behavioral responses in mice. Their work reveals that SOC elicits unique behavioral signatures depending on th...

Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to c...

Daily choices are determined by prior direct or indirect associations between low-salience cues and reinforcers. In this study, we used a mouse odor-taste sensory preconditioning task combined with ge...

Daily choices are often influenced by environmental cues that are not directly linked to reinforcers. This process is known as higher-order conditioning and can be measured using sensory preconditioni...