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Reposted by Bernhard Magerl

Tommaso Cavazza @cavazzalab.bsky.social · 23/01/2025

@bernhard-m.bsky.social and I wrote a commentary on a cool paper published on NSBM by the Lin lab. The article is about a new ELL3ment in spindle assembly related to maternally inherited aneuploidy and infertility. Article👉 nature.com/articles/s41594-024-01471-8 Our commentary👉 rdcu.be/d68El

nature.com

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage - Nature Structural & Molecular Biology

The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early ...

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