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@Bernard-S-Lopez.bsky.social @bernard-s-lopez.bsky.social · 11/06/2025

The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability. (A new role for the oncogene AKT1: the phosphorylation of MRE11). academic.oup.com/nar/article-...

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Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1

Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic

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