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Ben Orr

@benorr.bsky.social
59 followers 114 following 9 posts

PhD Candidate, UCSF Biophysics, Kortemme Lab Computational Biology & AI Lead, Animate Bio ML for Protein Design

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Reposted by Ben Orr
Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 16/06/2025
Deep learning methods for protein structure prediction and design produce idealized structures. Finetuning on a set of physics-based de novo proteins improves their geometric diversity and generalization capabilities. @benorr.bsky.social @kortemmelab.bsky.social www.biorxiv.org/content/10.1...
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Ben Orr @benorr.bsky.social · 10/06/2025
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) www.biorxiv.org/content/10.1...
biorxiv.org
An improved model for prediction of de novo designed proteins with diverse geometries
Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, ideali...
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