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Andres Bendesky

@bendeskylab.com
1.2K followers 458 following 135 posts

Neuroscience – behavior – genetics – evolution Columbia University

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Andres Bendesky @bendeskylab.com · 11/05/2026
California mice are paragons of monogamy. The neuronal bases of how they (or any other species) remember their partners is unknown. We found a surprisingly important role for hippocampal CA1 as the pair bond develops and a concomitantly diminishing role of CA2. www.biorxiv.org/content/10.6...
Pair of California mice taking care of their pups
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Andres Bendesky @bendeskylab.com · 17/04/2026
Many wild populations are fragmenting and declining, leading to inbreeding. We are studying how animals avoid inbreeding and the consequences of inbreeding an in a >20 year study of >20,000 wild mice with whole genomes. We are recruiting a postdoc at Columbia and two PhD students in U Zurich.
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Andres Bendesky @bendeskylab.com · 21/11/2025
Congrats on the very cool and thorough work! We also found that variation in the related gene alkal2l is a main cause of red-blue color differences in betta. Knocking it out abolishes iridescence. Interesting convergence. www.science.org/doi/10.1126/... www.frontiersin.org/journals/gen...
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Andres Bendesky @bendeskylab.com · 01/11/2025
The Borborites were a fun bunch en.wikipedia.org/wiki/Borbori...
Sexual sacramentalism
Epiphanius claims that the Borborites were inspired by Sethianism and that elements of sexual sacramentalism formed an important role in their rituals. He asserts that the Borborites engaged in a version of the eucharist in which they would smear their hands with menstrual blood and semen and consume them as the blood and body of Christ respectively.[4] He also alleges that, whenever one of the women in their church was experiencing her monthly period, they would take her menstrual blood and everyone in the church would eat it as part of a sacred ritual.[9]
The Borborites were also said to extract fetuses from pregnant women and consume them, particularly if the women accidentally became pregnant during related sexual rituals.[10] Buckley notes that this implies treatment of an aborted foetus as "strayed semen", and would serve to prevent it from developing into another body "for the archons' clutches".
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Andres Bendesky @bendeskylab.com · 06/10/2025
Without bco1l, young animals don't grow nor swim properly and they have a deficit of VA and retinoic acid after they exhaust the retinoids stored in the yolk. Growth and behavior are rescued by retinoic acid supplementation.
Vitamin A production during betta development. From 0 to 5 dpf, maternally deposited retinal in the yolk is utilized to produce the essential metabolite retinoic acid and the visual chromophore (11-cis retinal). Once the yolk stores of retinal are depleted, developing betta transition to retinoid production through the metabolism of dietary carotenoids. From 5-15 dpf, betta convert β-carotene from rotifer feeds to retinal via the 15,15’ oxygenase activity of bco1l. From 15 dpf to adulthood, betta rely on the provitamin A ketocarotenoid content of Artemia feeds. These molecules are likely converted to β-carotene through an unknown pathway and subsequently cleaved by bco1l.
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Andres Bendesky @bendeskylab.com · 06/10/2025
bco1l is 4x less abundant than bco1l in the skin and 4x more abundant in the intestine. Consistent with such expression, pearl danio fish mutant for bco1 only have a subtle pigmentation defect (doi.org/p8jx). By contrast we found bco1l to be essential for betta fish juvenile development and survival
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Andres Bendesky @bendeskylab.com · 06/10/2025
Whereas other vertebrates use bco1 for converting dietary beta-carotene and other carotenoids into Vitamin A, we found that bco1-like evolved via duplication from bco1 in the ray-finned fishes. These are the most speciose, abundant and commercially important group of fishes.
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Andres Bendesky @bendeskylab.com · 15/09/2025
You mean this from samtools dot org is not a human-made graph?
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Andres Bendesky @bendeskylab.com · 08/09/2025
New review on how changes in cell type composition in and outside the brain contribute to the evolution of behavior. 🧪 authors.elsevier.com/a/1lihM,LqAZ...
Changes in cell type composition, including cell expansions, cell losses, and novel cell gains, are associated with the evolution of specific behaviors.
Figure credit: Matteo Farinella.
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Andres Bendesky @bendeskylab.com · 04/09/2025
My favorite example is from the Chromosome Substitution Strains of Joe Nadeau. Without epistasis you expect that the phenotypes of each chromosome substitution would add up to 100% of the difference between strains yet they found that for 40/41 traits it added to ~800%! doi.org/10.1073/pnas...
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Andres Bendesky @bendeskylab.com · 04/09/2025
Lots of examples from experiments using loss of function mutations in Drosophila, C. elegans, yeast... Here's one example from quantitative genetics in C. elegans that I discovered in my PhD: The effect of tyra-3 alleles depends on genetic background. www.nature.com/articles/nat...
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Andres Bendesky @bendeskylab.com · 30/08/2025
This haplotagging method is not based on 10x, it is DIY. It is also cheap.
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Andres Bendesky @bendeskylab.com · 13/05/2025
This is Julio. We adopted him when he was 3 months old and has been with us for 17 years. He is a good boy.
Julio, a chocolate-colored long-hair miniature dachshund, hiking in the Catskills.
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Andres Bendesky @bendeskylab.com · 05/04/2025
Yes!
Big rally in NYC
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Andres Bendesky @bendeskylab.com · 03/03/2025
Total cost of new R01s awarded since Feb 1, 2025, by IC. Many institutes —even some that had council meetings in January— have awarded 0 or 1 R01s since then. cc @jeremymberg.bsky.social
NIAID and NCI have granted much more money since February 1st, 2025 than other NIH institutes.
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Andres Bendesky @bendeskylab.com · 06/12/2024
Very cool new work by Jonny Kohl's lab on how hunger promotes infanticide dependent on the estrus cycle in mice. When hungry, Agrp neurons in the hypothalamus arcuate release NPY onto the medial preoptic area, promoting an infanticide aggressive state www.biorxiv.org/content/10.1...
Integration of hunger and estrous state in MPOA neurons.
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Andres Bendesky @bendeskylab.com · 06/12/2024
"There are no genes that predispose to divorce, but people with similar genomes are more likely to have similar marital status." Useful analogy by @ent3c.bsky.social between Galton's quincunx, heritability and genetic causality and associations. substack.com/home/post/p-...
Francis Galton's quincunx
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Andres Bendesky @bendeskylab.com · 15/10/2024
Applications are now open for Columbia's Zuckerman Institute Alan Kanzer Postdoctoral Fellowship. This is your chance to pursue pioneering research into critical aspects of the brain. bit.ly/KanzerFellows
Kanzer Postdoctoral Fellowship details
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Andres Bendesky @bendeskylab.com · 15/08/2024
Cafebrería El Péndulo (pendulo.com/especial/suc...) has been doing this in Mexico City for over 30 years. It's wonderful.
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Andres Bendesky @bendeskylab.com · 15/05/2024
Using genetic mapping, we find the genetic bases of the evolution of the zona inaudita. Surprisingly, it is not due to mutations in transcription factors. Instead two genes seem particularly important: the nuclear protein Gadd45a, and the extracellular matrix protein Tenascin N
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Andres Bendesky @bendeskylab.com · 15/05/2024
Interestingly, allo-pregnanediol is very similar to allo-pregnanolone, which is the only drug approved for treating postpartum depression. Tempting to think that oldfield mice are making their own anti-postpartum depression medication 😊
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Andres Bendesky @bendeskylab.com · 15/05/2024
20⍺-hydroxyprogesterone is then converted in the brain into allo-pregnanediol another poorly studied molecule also present in humans. We find that allo-pregnanediol acts on GABA receptors to shape neuronal activity but other receptors are possibly involved.
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Andres Bendesky @bendeskylab.com · 15/05/2024
A single injection of 20⍺-hydroxyprogesterone is enough to induce parental behavior in both deer mice and oldfield mice!
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Andres Bendesky @bendeskylab.com · 15/05/2024
The zona inaudita evolved very recently, since we only find it in oldfield and beach mice (subspecies of Peromyscus polionotus) but not in cloudland deer mice (P. maniculatus nubiterrae), from which polionotus diverged ~20,000 years ago nor in other Peromyscus species
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Andres Bendesky @bendeskylab.com · 15/05/2024
Part of the reason the oldfield adrenal is so large, is that it contains a cell type that is not present in deer mice, nor house mice, nor humans. This cell type forms a concentric layer that we named zona inaudita, or previously-unheard-of zone.
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Andres Bendesky @bendeskylab.com · 15/05/2024
While doing old-fashioned necropsies, we discovered that the adrenal glands of oldfield mice are 4x-larger (6x after adjusting for body size) than those of their sister species, the deer mouse. This is an unprecedented difference in organ size between closely-related species.
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Andres Bendesky @bendeskylab.com · 15/05/2024
Excited to share our newest paper, in which we report our discovery that monogamous oldfield mice have very recently evolved a novel cell type in their adrenal glands that promotes parental care Work led by the fabulous Natalie Niepoth and @jennymerritt.bsky.social 🧵 rdcu.be/dH1Kn
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Andres Bendesky @bendeskylab.com · 02/05/2024
Through analyses of neuronal activity followed by lesions, we then found that a region of the betta brain homologous to our amygdala is very important for maintaining engagement in an aggressive interaction 8/
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Andres Bendesky @bendeskylab.com · 02/05/2024
We also investigated the role of elevation in driving the persistence of flaring, finding that fish flare more at a fish near the surface of the water. This is interesting, since many important facets of the life of betta happen near the surface. 7/8
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Andres Bendesky @bendeskylab.com · 02/05/2024
Betta are a great model for visual turn taking. Before starting to fight, betta perform robust and ritualized aggressive displays, epitomized by gill flaring. Early observations documented how betta take turns flaring, preferring to flare when their opponents are broadside to them 3/8
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Andres Bendesky @bendeskylab.com · 02/05/2024
How do animals know when it’s their turn to communicate during a conversation? In our latest preprint, we study the behavior and neurobiology of aggressive visual turn-taking of Siamese fighting (betta) fish to find out. Work lead by Claire Everett 🧵 1/8 www.biorxiv.org/content/10.1...
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