iiinova — where your digital self keeps evolving

Beatriz Gros @bealoquebea.bsky.social · 11/03/2025

Grateful to have worked with this amazing team on this project! To curb the rapid rise of #IBD, we must understand both risk & protective factors Our latest research explores key environmental influences to guide prevention strategies academic.oup.com/ecco-jcc/adv...

020

Beatriz Gros @bealoquebea.bsky.social · 08/03/2025

Time turns people into legends 1/🧵 on one of the most important women in med history: Gertrude B. Elion You may not know her, but her discoveries changed medicine She co-developed thiopurines (azathioprine, mercaptopurine), a breakthrough in immunosuppressive therapy, & won the Nobel Prize in 1988

172

Beatriz Gros @bealoquebea.bsky.social · 01/03/2025

🔎Strictures in Crohn's disease can be challenging to manage I've put together a summary on different approaches and an infographic on strictureplasties Patients want to know about this, so I hope this can serve as an useful resource 🆕www.ibd-eii.com/ibdcheatsheet #IBD

030

Beatriz Gros @bealoquebea.bsky.social · 01/03/2025

050

Beatriz Gros @bealoquebea.bsky.social · 28/02/2025

Wrapping up February with the latest updates on www.ibd-eii.com ! This month's newsletter, coming this evening, includes new triss and #IBD cheatsheets! Some interesting research, like this one on hemorrhoid therapy in IBD (📷). Stay tuned!

040

Beatriz Gros @bealoquebea.bsky.social · 25/02/2025

Paradigm Shift in Inflammatory Bowel Disease Management: Precision Medicine, Artificial Intelligence, and Emerging Therapies Our latest publication www.mdpi.com/2077-0383/14...

0103

Beatriz Gros @bealoquebea.bsky.social · 22/02/2025

REScUE trial of patients with CD losing response to UST All patients received IV reinduction and then q4w SC vs q8w SC ❗️Primary outcome: SF clinical remission: PRO2 & FCP <250 & no steroids for 90 days before w48 ‼️Less than 20% met primary outcome #ECCO2025

040

Beatriz Gros @bealoquebea.bsky.social · 22/02/2025

Clusters of antibiotic use patterns after the first episode of pouchitis 4⃣ groups: rare intermittent > intermittent > chronic antibiotic-responsive > chronic antibiotic dependent antiTNF prior IPAA & antibióticos in the 12 months prior pouch formation associated with chronic pouchitis #ECCO2025

010

Beatriz Gros @bealoquebea.bsky.social · 22/02/2025

Phase 1b study of SOR102, orally delivered bispecific anti-TNF/anti-IL-23 domain antibody in mild to severe UC !! Phase 1b very small N so caution with interpretation It surprised me the fact that it includes also patients with mild #UC? giving a double acting #IBD #ECCO2025

000

Beatriz Gros @bealoquebea.bsky.social · 22/02/2025

Very nice tandem of @Iris_Dotan and Revital Barkan about how far should we pursue our targets to help patients live a normal life? ✅How fast should we act? FASTER & FURTHER ✅Stratify patients better ✅Multidisciplinary approach 🌍Address community gaps

040

Beatriz Gros @bealoquebea.bsky.social · 22/02/2025

Duvakitug (TEV-48574) Anti-TL1A- RELIEVE UCCD trial Results from a Phase 2b trial #IBD #CD #ECCO2025

373

Beatriz Gros @bealoquebea.bsky.social · 19/02/2025

None better than @ibdseb.bsky.social to talk about underrepresented populations in #IBD research #ECCO2025 Difficult to choose the best slides, thanks Seb

0101

Beatriz Gros @bealoquebea.bsky.social · 19/02/2025

School for Clinical trialist #ECCO2025 Starting by @J_Kirchgesner introducing how to set your path from the early days #ibd

020

Beatriz Gros @bealoquebea.bsky.social · 19/02/2025

How to organize an IBDD research Unit from Scratch by @SeverineVermei1 #ECC02025 #ibd

052

Beatriz Gros @bealoquebea.bsky.social · 19/02/2025

How to create a global consortium by @DrAilsaHart at #ECCO2025 Huge expertise with the perianal disease consortium Great to see how this has progressed from the first idea #ibd

053

Beatriz Gros @bealoquebea.bsky.social · 19/02/2025

Outstanding review by Nuru Noor revisiting the design of clinical trials #ECCO2025 #ibd

052

Beatriz Gros @bealoquebea.bsky.social · 09/02/2025

Two years ago,I had a crazy idea I want to say thank you to everyone who saw a young girl believing in herself and chose to believe in her too 📈390k visits & more than 39k users.Reminder that science knows NO borders & we are all connected by the same passion & mission:to help others #ibd

0120

Beatriz Gros @bealoquebea.bsky.social · 03/02/2025

Meeting Brigida Barbeiro, someone I have admired for years for her work in #IBD thanks to @myueg.bsky.social

040

Beatriz Gros @bealoquebea.bsky.social · 02/02/2025

Also updated the doses tables for #IBD be aware that mirikizumab has different dosage for #UC and #CD!

120

Beatriz Gros @bealoquebea.bsky.social · 02/02/2025

With the recent approval of mirikizumab for #Crohnsdisease and guselkumab for #UC, I’ve updated the tables on the website 📊 Thanks to one of your suggestions,they now include the update date 📅 I appreciate your help in improving the content! 🔗 www.ibd-eii.com/ibdcheatsheet #IBD #ulcerativecolitis

2122

Beatriz Gros @bealoquebea.bsky.social · 28/01/2025

Understanding the complexity of chronic illnesses is no easy task I created this figure with insights from patients to shed light on the multidimensional aspects of IBD. Find the full-quality version on my website or in your inbox if you are subscribed—feel free to use it! 🌟

141

Beatriz Gros @bealoquebea.bsky.social · 26/01/2025

It's hard to believe, www.ibd-eii.com is about to turn 2️⃣years old Next week, I'll send out the pre-anniversary email, with new summaries like this one Thank you for your support and for keeping me motivated If you want to subscribe Just 1 📩totally free #IBD

040

Beatriz Gros @bealoquebea.bsky.social · 24/01/2025

Here with Lumir and @anadugic.bsky.social thrilled to collaborate shaping UEG education

060

Beatriz Gros @bealoquebea.bsky.social · 09/01/2025

VEDOKIDS Maintenance treatment with vedolizumab in paediatric inflammatory bowel disease just published ✅ At w54 47% UC/IBDU in clinical remission and 24% of CD 🌟 More studies to prove safety & efficacy in pediatric population needed www.sciencedirect.com/science/arti... @thelancet.bsky.social

031

Beatriz Gros @bealoquebea.bsky.social · 18/12/2024

The QUASAR trial- guselkumab vs placebo in mod-severe UC 1️⃣Induction 200mg IV (0,4,8) or placebo 📗Maintenance 200mg SC q4w, 100mg SC q8w or placebo Guselkumab better than placebo in all the outcomes @thelancet.bsky.social www.thelancet.com/journals/lan...

033

Beatriz Gros @bealoquebea.bsky.social · 08/12/2024

4) Industry-sponsored trials bring funding & prestige to centres and investigators so we analyzezed these from 1997-2023 (n=293, 3,772 authors) Female authors: 24.1%, but most were affiliated with pharma. Non-pharma female authors were in reality 15.8% (similar observation was not seen among males)

130

Beatriz Gros @bealoquebea.bsky.social · 08/12/2024

2) We analyzed primary investigators & key author positions- 1st, 2nd, senior & corresponding-for gender&race - Female: 17.1% of 1st & 6.1% of senior authors - Non-white author: 12.3% 1st & 5.9% of senior First time we see a female as 1st author 1974 & senior in 2004 and % plateaued since then

110

Beatriz Gros @bealoquebea.bsky.social · 08/12/2024

1) How significant are gender & racial disparities in authorship representation in #IBD trials? any progress? N=438 trials;5517 authors (26.3% female) Female PIs: 24.2% & Non-white PIs: 18.8 Since 1971 (1st trial including a female author) representation has improved, but still far from balanced

163

Beatriz Gros @bealoquebea.bsky.social · 01/12/2024

Sunday read: Spanish group geteccu position paper on ❤️vascular disease in #IBD ⬆️VTE even in remission ⬆️15-25% increased risk of Atherosclerotic Cardiovascular Disease (ASCVD) ❗️ASCVD risk is especially elevated in young ❗️Subclinical atherosclerosis often seen in IBD www.elsevier.es/es-revista-g...

081

Beatriz Gros @bealoquebea.bsky.social · 27/11/2024

🎉The latest IBD-Ell newsletter is out! - New trials added 🌟We've far surpassed 400 summarized trials🌟 - New guidelines - New cheat sheet with lymphocyte trafficking and anti-integrins Thanks for following along! www.ibd-eii.com Subscribe for free anytime 📩 #IBD

22011

Beatriz Gros @bealoquebea.bsky.social · 23/11/2024

Not only Gil Kaplan has presented the global epidemiological trends in a fantastic way, but he has also given us hope that, despite the challenges, we can curb the rising trends in #IBD if we work together. Speechless—thank you, Gil! 🙏

052

Beatriz Gros @bealoquebea.bsky.social · 23/11/2024

The great unknown: What is happening with IBD in Africa? What's the epidemiological situation in this vast & diverse continent❓ So many challenges highlight the urgent need to better characterize this, raise awareness & improve diagnosis Thanks Dr Mohamad Alboraie for your incredible work! 🌍 #IBD

040

Beatriz Gros @bealoquebea.bsky.social · 23/11/2024

The dedication to clarifying epidemiological trends in Latin America and the efforts to study disease patterns of Paolo Kotze are truly commendable. 👏 #Epidemiology #IBD

050

Beatriz Gros @bealoquebea.bsky.social · 22/11/2024

It seems like things are picking up towards the end of the year 🏁🏎️ The VIVID-1 trial,mirikizumab in mod-severe #CD Unlike SEQUENCE this is a double-blind, double-dummy, placebo-controlled AND active-control with ustekinumab AND not all patients had failed TNF www.sciencedirect.com/science/arti...

0104

Beatriz Gros @bealoquebea.bsky.social · 19/11/2024

Vedolizumab to prevent postop recurrence in #CD within 4w of surgery IV vedolizumab (300 mg) or placebo at weeks 0, 8, 16, and 24 www.sciencedirect.com/science/arti...

0100

Beatriz Gros @bealoquebea.bsky.social · 17/11/2024

I know I'm a bit late, but here's the updated table of #IBD treatments with their doses & routes of administration with the addition of guselkumalb Full quality table ➡️ www.ibd-eii.com/ibdcheatsheet/

1347

Beatriz Gros @bealoquebea.bsky.social · 16/11/2024

Evidence of biologics in pediatric #IBD

052

Beatriz Gros @bealoquebea.bsky.social · 15/11/2024

🌟Ever found yourself doubting about IBD new drugs doses? or forgetting Thiopurine metabolism details? I've been there too 🤩 So I thought it could help having "IBD Cheat Sheets" and that is what I did: ibd-eii.com/ibdcheatsheet/ I hope it helps as much as it helps me

0145

Beatriz Gros @bealoquebea.bsky.social · 15/11/2024

Amazing women in #IBD meeting Seasons recorded at www.md-education.com/medical-conf...

130