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Aurina Arnatkeviciute

@aurinaarn.bsky.social

117 followers 118 following 10 posts

Neuroscience | brain imaging and genetics Research Fellow at Monash University, Australia

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Reposted by Aurina Arnatkeviciute

NSB Lab @nsb-lab.bsky.social · 27/06/2025

Good morning #ohbm2025! We still have a host of great posters to present over the last two days of the conference so keep your eyes peeled 👀 1573 - #multi-echo #fMRI 1666 - #heterogenous modes 1696 - new #psychosis dataset 1708 - #eigenmodes in #mice 1773 - linking #geometry & #connectome Details👇

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 18/04/2025

If that sounds interesting, let us know! For more information DM or email me (aurina.arnatkeviciute@monash.edu) or @jchrispang.bsky.social (james.pang1@monash.edu)

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 18/04/2025

We are hiring! Join us at Monash Uni (Melbourne, AU) @jchrispang.bsky.social and I are looking for a motivated PostDoc in Systems and Comp Neuro to work on 🧠neuroimaging, 💻computational models, 🧬genetics, 😶‍🌫️brain disorders and/or 🐵evolution. tinyurl.com/MonashPostdo...

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 11/02/2025

According to our analysis and null model (which is quite stringent, but allows to ask a reasonable question) -- only in special cases, e.g. bipolar disorder. Matches for other disorders are very limited if any.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

6/6 But the correspondence for most other psychiatric disorders rarely exceeds null expectation suggesting that the genetic mechanisms driving the risk for psychiatric disorders may be distinct from the pathophysiological mechanisms targeted by drugs.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

5/6 We show that incorporating information derived from functional bioinformatics data, such as the PPI network can reveal links between GWAS and drugs for some disorders (bipolar disorder and diabetes [used for comparison]).

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

4/6 We propose a robust and realistic null model for significance testing that expects the identified matches to be specific for the selected group of treatments. Meaning that treatments for a selected disorder are expected to exceed matches for other treatments.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

3/6 Here we integrate different functional information from protein-protein interactions, expression quantitative trait loci (eQTL), and spatial gene expression to determine the correspondence between GWAS hits and the genes for current drug targets.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

2/6 Psychiatric disorders (most having a developmental component) present a special case, where the genetic risk that creates a vulnerability to illness may be distinct and separated in time from the pathophysiological mechanisms that influence symptom onset and severity.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

1/6 GWASs were expected to inform the development of pharmacological treatments, such that identifying genetic variation associated with the disorder would provide targets for drug action. However, the direct translational applications have not yet been developed.

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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025

Do psychiatric GWASs find drug targets? Excited to see our work linking GWAS and pharmacological treatments in psychiatric disorders now published in JAMA Psychiatry jamanetwork.com/journals/jam... 🧬💊🎯 Big thanks to @bendfulcher.bsky.social @alexfornito.bsky.social Mark Bellgrove 🧵👇

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Reposted by Aurina Arnatkeviciute

James Pang @jchrispang.bsky.social · 03/02/2025

For my first-ever bluesky post, I'm really excited to share our new preprint "Geometric influences on the regional organization of the mammalian brain" with @alexfornito.bsky.social and a superstar 17-person team! (1/n) www.biorxiv.org/content/10.1...

biorxiv.org

Geometric influences on the regional organization of the mammalian brain

The mammalian brain is comprised of anatomically and functionally distinct regions. Substantial work over the past century has pursued the generation of ever-more accurate maps of regional boundaries,...

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