Audrey Hendricks @audreyhendricks.com · 10/04/2025We have a fantastic time attending the NHGRI trainee conference in Philadelphia. Great and inspirational science! (And Ben Franklin is everywhere!) #NHGRI #PATH-GDS #PATH-GREU 140
Audrey Hendricks @audreyhendricks.com · 21/03/2025At the Sanders/AOC stop Fighting Oligarchy in Denver! Y’all, the crowd is huge! Probably at least 50k! 050
Audrey Hendricks @audreyhendricks.com · 07/03/2025Denver #StandUpForScience ! Freezing but totally worth it!! 1275
Audrey Hendricks @audreyhendricks.com · 03/03/2025Our signs for Friday’s #standupforscience2025 !! 020
Audrey Hendricks @audreyhendricks.com · 17/01/2025Summix2 also enables estimation of local substructure across the genome enabling scans for potential regions of selection. (7/9) 100
Audrey Hendricks @audreyhendricks.com · 17/01/2025Identify other genetic substructure ie, genetic similarity to disease. In CO Biobank, we found older ages had a higher proportion of genetic similarity to prostate cancer cases. Maybe selection bias where people with PC come to the health system for treatment and are recruited to the Biobank. (6/9) 100
Audrey Hendricks @audreyhendricks.com · 17/01/2025Genetic similarity map adjustment & visualization. Even with bias in substructure estimates, the bias is not propagated for harmonization! Using a genetic similarity map is closer to a continuous representation of genetic ancestry in summary data & denser maps will likely improve harmonization (5/9) 110
Audrey Hendricks @audreyhendricks.com · 17/01/2025Summix2 builds off our initial Summix method (AJHG 2021) characterizing finer-scale population structure using 50 reference groups compared to 5 continental level groups in v1. We use this to harmonize genetic summary data to match an individual or sample. (3/9) 100
Audrey Hendricks @audreyhendricks.com · 17/01/2025Summix2 detects and harmonizes for genetic substructure in summary data increasing the utility of *all* genetic summary data, especially for admixed populations. (2/9) 100