Chronic opioid use facilitates changes in brain reward and affective systems. Cessation of opioid use induces negative affective states characterized …

Designing good research questions goes well beyond the standard definitions of clarity, focus and tractability, and even beyond ‘novelty’ in the strictest sense. This Comment describes the iterative c...

People suffering from severe alcohol and opioid addiction are to be offered a revolutionary new technique involving planting electrodes in the brain to modulate brain activity and cravings and improve...