Reposted by @atakkatan.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
dlvr.it
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function, thus engaging in a pro-allergic dialogue that promotes type 2 immunity.
