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Spakowitz Lab @aspakowitz.bsky.social · 15/12/2025

Our paper in JCP utilizes polymer field theory to explore the impact of solvent correlation and dielectric inhomogeneity on polyelectrolyte phase behavior. My student, Michael, did an outstanding job in addressing this fundamental problem in polymer science. pubs.aip.org/aip/jcp/arti...

pubs.aip.org

Influence of dipolar solvent fluctuations on polyelectrolyte thermodynamics and complex coacervation

We present a self-consistent polyelectrolyte field theory that reveals the impact of solvent polarity and polymer semiflexibility on polyelectrolyte solution th

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Spakowitz Lab @aspakowitz.bsky.social · 18/11/2025

Our recent manuscript “Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk” was published in PNAS. Joe Wakim used simulations and machine learning to reveal mechanisms for programming and reprogramming of cell behavior. www.pnas.org/doi/10.1073/...

pnas.org

Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk | PNAS

The spatial organization of chromatin is governed by epigenetic factors, including epigenetic marks and the reader proteins that bind them. By dict...

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Spakowitz Lab @aspakowitz.bsky.social · 18/11/2025

Thomas Habte and I recently published “Leveraging inhomogeneous binding of incompatible constituents for adaptive copolymer self-assembly” in Soft Matter, predicting a new co-polymer material that can access a range of stable phases without changing polymer sequence. pubs.rsc.org/en/content/a...

pubs.rsc.org

Leveraging inhomogeneous binding of incompatible constituents for adaptive copolymer self-assembly

Using a polymer field-theoretic model, we present a system containing copolymers and two distinct chemical moieties that bind heterogeneously along the copolymer chains, enabling self-assembly of a ra...

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Spakowitz Lab @aspakowitz.bsky.social · 17/11/2025

The Spakowitz Lab at Stanford (Theory and Computation of Biological Processes and Soft Materials) is delighted to join the Bluesky community! We look forward to sharing our work and to learning about your research achievements.

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