Excited to share our new paper in JAC!
Used 96h hollow fiber infection models with Stenotrophomonas maltophilia isolates to compare aztreonam/avibactam vs aztreonam+ceftazidime/avibactam. Assessed killing durability and blaL1/blaL2 expression.
Thanks to the team!
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academic.oup.com
Durability and mechanistic performance of aztreonam/avibactam versus aztreonam plus ceftazidime/avibactam against Stenotrophomonas maltophilia complex
AbstractBackground. Stenotrophomonas maltophilia complex infections are difficult to treat because of intrinsic resistance mediated by the L1 metallo-β-lac