iiinova — where your digital self keeps evolving

Asaf (Klaf) Weisman @asafklaf.bsky.social · 10/05/2026

A new blog on our study, which was published last year in PeerJ, and why it KILLED all the psychologically-based interventions for pain, including "Pain Reprocessing Therapy." YES, It KILLED those approaches! #painscience #painresearch painlosophy.wordpress.com/2026/05/10/s...

painlosophy.wordpress.com

Special Pleading for Dead Psychological Theories of Pain

By: Asaf Weisman I am probably among the most educated people about pain in the world. Thirty years of fibromyalgia. Deep familiarity with pain neuroscience, mindfulness, and the whole theoretical …

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 20/10/2025

This new prospective study followed 108 individuals with acute low back pain. Their immune profiles predicted transition from acute to chronic low back pain in a sex- and age-specific manner with some pretty impressive AUCs. journals.lww.com/pain/abstrac... #neuroskyence #painresearch #physio

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 16/10/2025

Potential and actual tissue damage are encoded the same. Both qualify as nociception. It is an ingenious evolutionary adaptation that is meant to protect us way before actual damage occurs.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 16/10/2025

Pinch yourself slightly hard and you will likely feel pain due to potential tissue damage.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 15/10/2025

Officially published💥 A reboot to the #pain field! The aphorism that “nociception is neither necessary nor sufficient for pain” has caused a lot of damage to patients and set back the field and should be discarded. #neuroskyence #painresearch #physio Free link: academic.oup.com/brain/advanc...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 09/10/2025

Metabolic disorders and pathophysiologies have many detrimental effects and are associated not only with tendinopathies but also with chronic #pain and are highly likely to be causal for these. This new review finds that diabetes has crazy effect sizes for many types of tendinopathies #physio #pain

esskajournals.onlinelibrary.wiley.com

The interplay between metabolic disorders and tendinopathies: Systematic review and meta‐analysis

This systematic review highlights a strong link between metabolic conditions and tendinopathies. Diabetes significantly increases the risk, especially for Achilles and upper limb tendinopathies. Dysl...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 08/10/2025

Very important and useful clinical information on the average age of onset of autoimmune diseases. From: www.thelancet.com/journals/lan... #physio #painscience

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 04/05/2025

A new medical illustration I made per request. I wish I could just do those all day. #painscience #neuroskyence #physio 🛟🧪

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 30/04/2025

They found a population of noxious heat and chemical irritation processing neurons - not “pain” and not “itch specific neurons”

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 16/04/2025

According to Betteridge's law of headlines, the answer to the titles question is: NO! The study found MICROSCOPIC effect sizes for the contribution of psychological factors in the persistence of shoulder pain! #physio #painscience 🧪🛟 journals.lww.com/clinicalpain...

journals.lww.com

Do Psychological Factors Explain the Persistence of... : The Clinical Journal of Pain

education program. Methods: One hundred forty-three individuals with persistent RCRSP were included in this prospective cohort study. At baseline, participants completed self-reported questionnaire...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 24/03/2025

The obvious questions are: how did they get those mice to report they were experiencing pain? And since when pain is being processed anywhere in the brain when pain is a response and the outcome of all processing?

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 05/03/2025

New study finds evidence for neuroinflammation in the periphery of individuals after WHIPLASH. Very well conducted study! Sample size ✅ control group ✅ Sig. findings on MRI ✅ Sig. findings on blood tests ✅ Sig. findings on QST ✅ #physio #neuroskyence #painresearch 🧪🛟

journals.lww.com

Evidence for peripheral neuroinflammation after acute... : PAIN

a subgroup with underlying nerve involvement in WADII, such as peripheral neuroinflammation. This study aimed to investigate the presence of neuroinflammation in acute WADII using T2-weighted magnetic...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 05/03/2025

journals.lww.com

Evidence for peripheral neuroinflammation after acute... : PAIN

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 16/02/2025

Fibromyalgia is a rabbit hole by itself. What have you learned from your quest?

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 08/02/2025

Striking cases of neuro-immune interactions: Upper pic: Psoriasis vanished from right hand after shoulder dislocation with brachial plexus injury. Bottom pic: Four months later, as nerves began to recover, psoriasis returned. #neuroskyence #painresearch #physio 🧪🛟

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 06/02/2025

New study with combined 7 Tesla MRI imaging and PET scan finds altered structures of nerves and neuroinflammation in migraine patients. Vey robust design that includes a control group and same cases as right/left side dominant migraines as controls. #painresearch #neuroskyence #physio 🧪🛟

academic.oup.com

Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine

Using multimodal imaging, Tohyama et al. show that individuals with migraine have white matter damage in the trigeminal nerve. This damage is associated wi

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 26/01/2025

New imaging technique published in Nature to image inflammation utilizes the protein CD-45 which is used only by white blood cells. Link: Link: www.nature.com/articles/s41... #painresearch #physio #neuroskyence 🛟🧪

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 22/01/2025

It just means that the mode of activation is not nociceptive nor neuropathic. Unfortunately, the term nociplastic pain has been hijacked by those with vested interests to sell and promote psychological treatments for those with “non structural pain. Do not cooperate with this trend!

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 22/01/2025

This activation can occur due to three mechanisms: nociceptive, neuropathic and nociplastic. It is now known that activation of nociception can occur independently and without observed tissue damage (nociplastic). This does not make nociplastic “non structural pain”

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 22/01/2025

There is no such thing as “STRUCTURAL PAIN” and “non structural pain” etc. The plethora of unpleasant sensory experiences we humans use the word “pain” to describe them, are all the consequences of activation of our specialized appartus of nociception. #painresearch #physio #neuroskyence

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 21/01/2025

It should be obligatory for every med/life sci grad student to learn formal logic & reasoning. Too many published papers are poorly argued and make basic inferential errors. This small change would dramatically improve science #physio #painresearch #neuroskyence 🧪🛟

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 13/01/2025

⭐️Surgery should be considered if leg pain and decreased walking distance are the main clinical features that disturb and affect the patient.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 13/01/2025

⭐️Eventually, at one year follow-up, both groups equalized in their outcomes,but the surgery group improved faster. ⭐️Functional tests are good at reflecting the subjective self assessment of patients with Spinal Stenosis and can be used for shared decision making.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 13/01/2025

What you can learn from the study: ⭐️ Leg pain and the decreased ability to walk are the main features that led those who opted for surgery. ⭐️Contrary to the vilification trend of lumbar surgery in healthcare, those with leg pain improved significantly faster than the wait and see group.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 05/01/2025

Not that I know of currently. But I created the soorts science feed bsky.app/profile/did:...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 05/01/2025

I created the #sportsskyence feed. Pin it bsky.app/profile/did:...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 26/12/2024

Instead of talking about the predatory nature of MDPI journals, can we talk about how UGLY their formatting is? It’s literally hurting my eyes reading their papers online and PDFs 😣 #painresearch 🧪

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 25/12/2024

I don’t think its a prank. I could be wrong though. The Scand J Pain has never published pranks or comic editions like the traditional BMJ Christmas issue.

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 25/12/2024

🤘🏻The study I have been waiting for 30 years! Only Scandinavians can pull this out let alone publish it in a Scandinavian pain journal 🤘🏻 #painscience #physio #painresearch #ignobel2025 www.degruyter.com/document/doi...

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 12/12/2024

Sapolsky found “pain circuitry” in humans and “painful stimuli” in nature? How, intriguing

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 11/12/2024

Since you haven’t noticed, I am ONLY talking about the nonsensical title. For some reason you took it as a personal attack on the authors and their paper which I said nothing about. If one is to engage in convo with peers, one needs to pay attention to the arguments

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 11/12/2024

Amazing that you are completely missing the point. It’s also funny how you assume I know nothing about those conditions. Thanks for the lecture though

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 11/12/2024

Educate me then. How can someone who is allegedly”insensitive to PAIN” have neuropathic PAIN? How is that even logical or not stupid? Have you actually thought this through, or are you just emotionally reacting?

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 10/12/2024

Today, in the stupid article title department... How is this nonsense acceptable? #painscience #painresearch #neuroscience

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 05/12/2024

Took it a bit, but just had the first sex bot follow me here 🙄

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Asaf (Klaf) Weisman @asafklaf.bsky.social · 02/12/2024

Welcome to the app. Pin the #sportsscience feed to yourhome to follow. bsky.app/profile/did:...

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