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Arvind Panday & Lab

@arvindpanday.bsky.social

227 followers 305 following 9 posts

My research lab at the Mayo Clinic studies genome maintenance and replication stress in carcinogenesis and associated therapy. Training and mentorship to assist lab members in achieving their goals are top priorities for my lab.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

This study was truly a team effort! Thanks to all authors! We gratefully acknowledge support from the National Cancer Institute (NCI) and Mayo Clinic Breast Cancer SPORE for funding this project. A particularly meaningful milestone for our young lab—and hopefully the first of many!

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

Together, our results position FANCM at the intersection of replication-stress tolerance, structural genome evolution, and synthetic-lethal vulnerability in BRCA1-deficient breast cancer.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

5. BRCA1-altered human breast tumors with low FANCM expression recapitulate key features of the experimentally observed duplication phenotype.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

4. FANCM limits transcription–replication encounters in BRCA1-deficient breast cancer cells, with newly emerging tandem duplications preferentially associated with Pol II-occupied genomic regions.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

3. FANCM loss in BRCA1-mutant breast cancer cells drives genome-wide structural variation, amplifying short tandem duplications while enabling larger tandem duplications and diverse rearrangements.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

2. A temporally controlled FANCM-depletion system was developed to track genome evolution in BRCA1-mutant breast cancer over successive cell divisions under endogenous replication stress, before declining cellular fitness becomes limiting.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

Key findings: 1. BRCA1 deficiency increases FANCM association with nascent replication forks, creating a synthetic-lethal dependency on FANCM across 2D and 3D breast cancer spheroid models.

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Arvind Panday & Lab @arvindpanday.bsky.social · 10/09/2026

🎉 Excited to share the first preprint from the Panday Lab! www.biorxiv.org/content/10.6... We identify FANCM as an adaptive genome-maintenance dependency in BRCA1-deficient breast cancer and uncover its role in restraining ongoing structural genome evolution.

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Arvind Panday & Lab @arvindpanday.bsky.social · 09/03/2025

It was worthwhile! Congratulations!

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