Arttu Jolma @arttujolma.bsky.social · 22/11/2024Hamed made a very nice summary of my new preprint about our new method and study for finding target sites of TFs in in vitro context, thus reflecting target sites without contribution of chromatin. 020
Reposted by Arttu JolmaIsaac Yellan @downbythebayes.bsky.social · 15/11/2024(1/8) 🚀 Excited to share our findings on a large-scale ChIP-seq assay for 166 previously uncharacterized human transcription factors (TFs) and their roles in both regulatory regions, and more strikingly, the “dark matter” genome. 🌌 doi.org/10.1101/2024....doi.orgExtensive binding of uncharacterized human transcription factors to genomic dark matterMost of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized tran... 39439