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Ariel Zeleznikow-Johnston

@arielzj.bsky.social
457 followers 2K following 111 posts

Neuroscientist, author | Book out now on brain preservation as a means of life extension: www.arielzj.com/the-future-loves-you | Currently a postdoctoral fellow in @conscious_tlab

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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 31/07/2026
Why is assisted dying so rare, even where it's legal? Even in the Netherlands, where assisted dying has been legal and normalised for over 20 years, only about 6% of people die this way. I dig into why so few use it, and why the trend is slowly increasing open.substack.com/pub/preservi...
open.substack.com
Why is assisted dying so rare, even where it’s legal?
And in the long run, how high will the rate become?
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 13/01/2026
Vale Ai, a chimpanzee artist who died today of age-related organ failure at 49. The max lifespan of our ape cousins is 40-60, which was likely the same for our early human ancestors too. If that seems short to you, think of what our descendants may think of a mere 80 years...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 16/12/2025
open.substack.com/pub/preservi...
open.substack.com
According to doctors, how feasible is preserving the dying for future revival?
A new survey of 334 US doctors gives it a 25% chance under ideal conditions
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 15/12/2025
I'm a 32yo neuroscientist. Good to know the Australian government is keeping me safe from all those dangerous ideas on Substack
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 08/12/2025
New preprint up: 'Physician estimates of the feasibility of preserving the dying for future revival' We surveyed 334 US doctors on how likely they thought preservation was to work, whether pre-legal-death interventions should be performed, and their ethical views. 🧵 www.medrxiv.org/content/10.6...
medrxiv.org
Physician estimates of the feasibility of preserving the dying for future revival
Importance: Terminally ill patients sometimes inquire about preservation procedures (e.g. cryopreservation, aldehyde-based fixation) as end-of-life treatment options, yet physician perspectives on fea...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 08/12/2025
New preprint up: 'Physician estimates of the feasibility of preserving the dying for future revival' We surveyed 334 US doctors on how likely they thought preservation was to work, whether pre-legal-death interventions should be performed, and their ethical views. 🧵 www.medrxiv.org/content/10.6...
medrxiv.org
Physician estimates of the feasibility of preserving the dying for future revival
Importance: Terminally ill patients sometimes inquire about preservation procedures (e.g. cryopreservation, aldehyde-based fixation) as end-of-life treatment options, yet physician perspectives on fea...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 18/11/2025
On this evening!
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 10/11/2025
Come along if you're at SfN on Monday next week! #SfN25
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 07/11/2025
Come along if you'll be at SfN!
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The Carboncopies Foundation @carboncopiesorg.bsky.social · 05/11/2025
Remembering past winners and nominations for the Aspirational Neuroscience Awards!
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The Carboncopies Foundation @carboncopiesorg.bsky.social · 05/11/2025
Memory Decoding advances nominated for 2025 Aspirational Neuroscience Awards!
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 23/10/2025
If people with advanced dementia really do sometimes cognitively recover just before death, i.e. terminal lucidity is real, it means that even severely damaged brains can have their function restored. It's crazy that science hasn't investigated this properly yet open.substack.com/pub/preservi...
open.substack.com
Is terminal lucidity real?
Or are we just desperate to say one last goodbye?
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 23/10/2025
If people with advanced dementia really do sometimes cognitively recover just before death, i.e. terminal lucidity is real, it means that even severely damaged brains can have their function restored. It's crazy that science hasn't investigated this properly yet open.substack.com/pub/preservi...
open.substack.com
Is terminal lucidity real?
Or are we just desperate to say one last goodbye?
131
Reposted by Ariel Zeleznikow-Johnston
Ariel Zeleznikow-Johnston @arielzj.bsky.social · 10/10/2025
Sydney people: I'm giving a talk at #SXSWSydney on Mon afternoon hosted by Tom Nash focusing on survey results of hundreds of neuroscientists on their thoughts about the feasibility of brain preservation for eventual uploading. Come check it out! www.sxswsydney.com/lineup?date=...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 10/10/2025
Sydney people: I'm giving a talk at #SXSWSydney on Mon afternoon hosted by Tom Nash focusing on survey results of hundreds of neuroscientists on their thoughts about the feasibility of brain preservation for eventual uploading. Come check it out! www.sxswsydney.com/lineup?date=...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 16/09/2025
When writing a chapter on how optogenetics enables memory manipulation (forced recall, erasure, etc), I was shocked that there were no popular science books that already covered the topic. I'm glad to see that's finally been remedied! Very much excited to read this.
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Francesco Ellia @ellia.bsky.social · 14/09/2025
New #preprint out! In this paper @naotsuchiya.bsky.social and I take a look at the current debate on theories of #consciousness from a #meta-theoretical standpoint, and we argue that there is an ongoing process of #schismogenesis in consciousness science. [1/n] www.researchgate.net/publication/...
researchgate.net
(PDF) Intrinsic Universal Structures and Extrinsic Local Functions
PDF | Contemporary consciousness science faces an impasse: competing theoretical frameworks, structuralist vs. functionalist, universal vs. local,... | Find, read and cite all the research you need on...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 03/09/2025
"I'd accepted losing my husband, until others started getting theirs back" open.substack.com/pub/preservi...
open.substack.com
"I'd accepted losing my husband, until others started getting theirs back"
"We're not just grieving the dead. We're grieving our own failure of imagination. And that's a grief our psychological frameworks aren't equipped to handle."
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 26/08/2025
Melbourne people, I'll be giving a talk at the @wheelercentre.bsky.social tomorrow. It's part of the Now or Never festival's theme this year: "I HAVE SEEN THE FUTURE" - very on topic for my book! nowornever.melbourne.vic.gov.au/event/twc-ta...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 25/08/2025
However much you appreciate sewers, it's not enough. Great piece on how our lives have gotten less shitty throughout history. www.asimov.press/p/sewers?r=4...
asimov.press
What We Find in the Sewers
Our ancestors once spread their excess effluent on their fields; now we mine it for vital molecules.
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 23/08/2025
@spencrgreenberg.bsky.social grilled me on: 1. Why do humans live 80 years, instead of 20 or 300? 2. How has the understanding of death changed over time? 3. If someone walks into a teleporter, who comes out the other end? Was a great discussion! podcast.clearerthinking.org/episode/276/...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 19/08/2025
Eating a delicious lunch is definitely the right place to make the case for an unlimited lifespan. Great piece by Cass Knowlton in @theageaustralia.bsky.social on my work and how it might help people enjoy great food indefinitely www.theage.com.au/national/vic...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 19/07/2025
"The treatment works like this: doctors use a modified teleporter that targets just one cubic centimeter of brain tissue at a time. That tiny chunk gets scanned, disintegrated, and instantly rebuilt in the exact same spot - minus any disease proteins." open.substack.com/pub/preservi...
open.substack.com
In-Place Teleportation And More: New Thought Experiments For Probing Personal Identity & Survival
In an era of shrinking science budgets, thought experiments remain affordable
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PLOS Biology @plosbiology.org · 14/07/2025
Awake, asleep or drugged? This #PreRegistered study in flies by @naotsuchiya.bsky.social &co uses a data-driven approach to search for markers that can determine the individual performance of time-series features in distinguishing levels of #consciousness @plosbiology.org 🧪 plos.io/44xzIeE
Top left: Flies were dorsally fixed to a rod and placed on an air-supported ball. Isoflurane was administered through a rubber hose. Top right: Local field potentials (LFPs) are obtained during wakefulness and anesthesia using linear multi-electrode arrays inserted laterally into the fly brain. Bottom left: At a given channel and time-series feature, they compute feature values for every epoch from each fly (each entry in the image plot corresponds to a scaled feature value from one epoch). Bottom right: As a weaker form of generalization, the authors also assess within-fly effect direction consistency by finding, for each wake epoch, the proportion of anesthesia epochs which have greater or lesser feature values.
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 15/07/2025
Do synapses come in analog or binary strengths? Come discuss tomorrow!
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 03/07/2025
If proponents of brain preservation/biostasis/cryonics want the field to become mainstream science, we need standards for what counts as a well-preserved brain. To become mainstream medicine, we need 3rd-party reviews and accreditation. The Brain Preservation Foundation wants to make this happen 1/n
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Aspirational Neuroscience @aspirationalneuro.bsky.social · 30/06/2025
Join tomorrow 3 pm PDT! Systems consolidation reorganizes hippocampal engram circuitry - carboncopies.org/Events/Journ... #neuroscience #memory #decoding #hippocampus #consolidation
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 27/06/2025
New paper showing cryopreservation & subsequent functional/electrophysiological recovery in both 1. hippocampal slices 2. partially in whole mouse brains (!) Great discussion of how to deal with osmotic shrinkage too www.biorxiv.org/content/10.1...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 25/06/2025
What do neuroscientists think is the physical basis of long-term memory? Could memory theoretically be read out from a static snapshot of brain structure? Our survey of hundreds of participants has just been published! 1/🧵
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 23/06/2025
Melbourne people, On Wed 27 Aug, I'll be giving a talk at the State Library (Wheeler Centre) about: -why we die -how by preserving someone's brain, we can stop them from dying -many other weird and fun things from my new book nowornever.melbourne.vic.gov.au/event/twc-ta...
nowornever.melbourne.vic.gov.au
How to Live Forever - Now or Never
Join neuroscientist Ariel Zeleznikow-Johnston as he offers a compelling argument for why human life could – and should – be eternal.
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 21/06/2025
Vale @helendecruz.net open.substack.com/pub/helendec...
open.substack.com
Let's face it, mortality sucks, much philosophizing about it is cope
Nowadays, I often consider the following three scenarios: (1) I am in remission (yay), (2) cancer has spread but is not dramatic; I will need more treatment (note: some treatments due to their destruc...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 17/06/2025
"How much delay could the brain withstand between the moment of death and the moment perfusion started? ...After hundreds of experiments on rats and mice, I found my answer: 12 minutes." @asteriskmag.bsky.social asteriskmag.com/issues/10/br...
asteriskmag.com
Brain Freeze—Asterisk
The idea of cryonics — freezing the bodies of the dead in the hopes that they can one day be revived — has existed since the 1960s. We’ve since learned that perfect preservation is much, much harder t...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 17/06/2025
"How much delay could the brain withstand between the moment of death and the moment perfusion started? ...After hundreds of experiments on rats and mice, I found my answer: 12 minutes." @asteriskmag.bsky.social asteriskmag.com/issues/10/br...
asteriskmag.com
Brain Freeze—Asterisk
The idea of cryonics — freezing the bodies of the dead in the hopes that they can one day be revived — has existed since the 1960s. We’ve since learned that perfect preservation is much, much harder t...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 16/06/2025
Come discuss how the cortex stores long-term memories with @aspirationalneuro.bsky.social on Tuesday when we discuss 'Neocortical synaptic engrams for remote contextual memories' by Lee et al (2023). Details here: aspirationalneuroscience.org/nlm-journal-...
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Aspirational Neuroscience @aspirationalneuro.bsky.social · 03/06/2025
Join us at the Memory Decoding journal club! "Structure and function of the hippocampal CA3 module" June 3 - carboncopies.org/Events/Journ... #aspirationalneuroscience, #memorydecoding, #hippocampus, #EM, #reconstruction
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Aspirational Neuroscience @aspirationalneuro.bsky.social · 31/05/2025
Join us at the Memory Decoding journal club! "Structure and function of the hippocampal CA3 module" June 3 - carboncopies.org/Events/Journ... #aspirationalneuroscience, #memorydecoding, #hippocampus, #EM, #reconstruction
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 29/05/2025
Are you a memory/engram researcher or know someone who is? Consider nominating a paper for one of the Aspirational Neuroscience's $25,000 Annual Research Awards given "To honor and highlight research into how learning and memory are physically encoded in the brain." aspirationalneuroscience.org
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 28/05/2025
"How sure are we that each of the green-colored structures are axons as opposed to dendrites, or microglia, oligodendrocyte, or astrocyte processes? 95% sure? 99%? 99.9%?" neurobiology.substack.com/p/action-pot...
neurobiology.substack.com
Action Potentials for May
1: Progress in connectomics continues apace.
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 22/05/2025
Highlights from Biostasis Week at Vitalitist Bay, including: 1. Problems with brain shrinkage in humans 2. Success with cryo-only methods in mice 3. Nectome's plans for perfect preservation Great to see so many people working on stopping ageing and pausing death! open.substack.com/pub/preservi...
open.substack.com
Biostasis Week at Vitalist Bay
Highlights from the conference
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 16/05/2025
Just got to SFO and excited to give a talk and hear from others at Biostasis Week! Going to be presenting survey data on what probabilities neuroscientists assign to the possibility of decoding memories from preserved brains. www.vitalistbay.com/biostasis
vitalistbay.com
Biostasis Week Conference (May 17-18) @ Vitalist Bay
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 12/05/2025
If decoding memories from preserved brains seems like science-fiction by today’s standards, consider that these guys have now (partially) figured out how to read a burned and buried scroll from two thousand years ago by cleverly analysing 3D X-rays of the still-rolled-up scrolls tinyurl.com/3p8y7w73
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 07/05/2025
"a protocol that physically expands brain tissue while preserving structural integrity, and at the same time chemically labels all proteins in order to provide the image contrast necessary for tracing neurons and detecting other cellular structures such as synapses." goo.gle/4maUNUs
goo.gle
A new light on neural connections
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 22/04/2025
My 'Australian Federal Election Policies Spreadsheet' makes a return for 2025, as requested by some of you. It includes a "make your own how-to-vote" creator on the second tab. If you spot any egregious errors or have any comments, please let me know. docs.google.com/spreadsheets...
docs.google.com
2025 Federal Election - Senate (Victoria) - Political Party Policy Guide - REFERENCE
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 22/04/2025
Memory Decoding Journal Club tomorrow with @AspirationNeuro "Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala" by Abatis et al., presented by @KennethHayworth April 22 10:00 PM UTC carboncopies.org/aspirational... All welcome!
carboncopies.org
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 20/04/2025
Claim that people can see color outside of the usual human gamut through laser-induced activation of solely M cones. Cool study, with color-matching results to back it up. But all they provide for subjective reports are "hue naming and saturation reports" :( www.science.org/doi/10.1126/...
science.org
Novel color via stimulation of individual photoreceptors at population scale
Image display by cell-by-cell retina stimulation, enabling colors impossible to see under natural viewing.
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 15/04/2025
"...the hypothalamus is often still mostly working in patients otherwise declared brain dead. While not at all compatible with the legal notion of ‘whole-brain’ death, this is quietly but consistently ignored by the medical community." open.substack.com/pub/preservi...
open.substack.com
What Is Death?
An excerpt from 'The Future Loves You'
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 15/04/2025
"...the hypothalamus is often still mostly working in patients otherwise declared brain dead. While not at all compatible with the legal notion of ‘whole-brain’ death, this is quietly but consistently ignored by the medical community." open.substack.com/pub/preservi...
open.substack.com
What Is Death?
An excerpt from 'The Future Loves You'
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 28/03/2025
If you're in Brisbane, come have a drink and a chat with me and some other scientists tomorrow!
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 21/03/2025
Everyone dies... ... until Joseph doesn't. Until Anne doesn't. Until Clyde doesn't. Until Ashanthi doesn't. Until Moisés doesn't. Until Emily doesn't. open.substack.com/pub/preservi...
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Ariel Zeleznikow-Johnston @arielzj.bsky.social · 21/03/2025
Everyone dies... ... until Joseph doesn't. Until Anne doesn't. Until Clyde doesn't. Until Ashanthi doesn't. Until Moisés doesn't. Until Emily doesn't. open.substack.com/pub/preservi...
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